ID H2QDW4_PANTR Unreviewed; 1090 AA.
AC H2QDW4; A0A2J8KB37;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=Unc-13 homolog D {ECO:0000313|Ensembl:ENSPTRP00000016410.6};
GN Name=UNC13D {ECO:0000313|Ensembl:ENSPTRP00000016410.6,
GN ECO:0000313|VGNC:VGNC:9764};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000016410.6, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000016410.6, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000016410.6}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the unc-13 family.
CC {ECO:0000256|ARBA:ARBA00005823}.
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DR EMBL; AACZ04070061; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_016786387.1; XM_016930898.1.
DR AlphaFoldDB; H2QDW4; -.
DR STRING; 9598.ENSPTRP00000016410; -.
DR PaxDb; 9598-ENSPTRP00000016410; -.
DR Ensembl; ENSPTRT00000017713.6; ENSPTRP00000016410.6; ENSPTRG00000009659.6.
DR GeneID; 454891; -.
DR KEGG; ptr:454891; -.
DR CTD; 201294; -.
DR VGNC; VGNC:9764; UNC13D.
DR eggNOG; KOG1328; Eukaryota.
DR GeneTree; ENSGT00730000110939; -.
DR HOGENOM; CLU_003295_1_0_1; -.
DR InParanoid; H2QDW4; -.
DR OMA; ICKTKAF; -.
DR OrthoDB; 3059697at2759; -.
DR TreeFam; TF315526; -.
DR Proteomes; UP000002277; Chromosome 17.
DR Bgee; ENSPTRG00000009659; Expressed in spleen and 19 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005768; C:endosome; IEA:UniProtKB-KW.
DR GO; GO:0070382; C:exocytic vesicle; IBA:GO_Central.
DR GO; GO:0005764; C:lysosome; IEA:Ensembl.
DR GO; GO:0033093; C:Weibel-Palade body; IEA:Ensembl.
DR GO; GO:0031267; F:small GTPase binding; IEA:Ensembl.
DR GO; GO:0051607; P:defense response to virus; IEA:Ensembl.
DR GO; GO:0002467; P:germinal center formation; IEA:Ensembl.
DR GO; GO:0002432; P:granuloma formation; IEA:Ensembl.
DR GO; GO:0043320; P:natural killer cell degranulation; IEA:Ensembl.
DR GO; GO:0006909; P:phagocytosis; IEA:Ensembl.
DR GO; GO:1903307; P:positive regulation of regulated secretory pathway; IEA:Ensembl.
DR GO; GO:1900026; P:positive regulation of substrate adhesion-dependent cell spreading; IEA:Ensembl.
DR GO; GO:0043304; P:regulation of mast cell degranulation; IEA:Ensembl.
DR GO; GO:0046903; P:secretion; IBA:GO_Central.
DR CDD; cd08676; C2A_Munc13-like; 1.
DR CDD; cd04009; C2B_Munc13-like; 1.
DR Gene3D; 1.10.357.50; -; 1.
DR Gene3D; 1.20.58.1100; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 2.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR010439; MUN_dom.
DR InterPro; IPR014770; Munc13_1.
DR InterPro; IPR014772; Munc13_dom-2.
DR PANTHER; PTHR45999:SF3; PROTEIN UNC-13 HOMOLOG D; 1.
DR PANTHER; PTHR45999; UNC-13-4A, ISOFORM B; 1.
DR Pfam; PF00168; C2; 2.
DR Pfam; PF06292; MUN; 1.
DR SMART; SM00239; C2; 2.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 2.
DR PROSITE; PS50004; C2; 2.
DR PROSITE; PS51258; MHD1; 1.
DR PROSITE; PS51259; MHD2; 1.
PE 3: Inferred from homology;
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Exocytosis {ECO:0000256|ARBA:ARBA00022483};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277}.
FT DOMAIN 92..239
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 557..677
FT /note="MHD1"
FT /evidence="ECO:0000259|PROSITE:PS51258"
FT DOMAIN 788..895
FT /note="MHD2"
FT /evidence="ECO:0000259|PROSITE:PS51259"
FT DOMAIN 910..1035
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT REGION 1026..1048
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1090 AA; 123298 MW; 334A428DB6E976E0 CRC64;
MATLLSHPQQ RPPFLRQAIK IRRRRVRDLQ DPPPQMAPEI QPPSHHFSPE QRALLYEDAL
YTVLHRLGQP EPNHVTEASE LLRYLQEAFH VEPKEHQQTL QRVRELEKPI FCLKATVKQA
KGILGKDVSG FSDPYCLLGI EQGVGVPGGS PGSRQRQKAV VRHTIPEEET HRTQVITQTL
NPVWDETFIL EFEDITNASF HLDMWDLDTV ESVRQKLGEL TDLHGLRRIF KEARKDKGQD
DFLGNVVLRL QDLRCREDQW YPLEPRTETY PDRGQCHLQF QLIHKRRATS ASRSQPSYTV
HLHLLQQLVS HEVTQHEAGS TSWDGSLSPQ AATVLFLHAT QKDLSDFHQS MAQWLAYSRL
YQSLEFPSSC LLHPITSIEY QWIQGRLKAE QQEELAASFS SLLTYGLSLI RRFRSVFPLS
VSDSPARLQS LLRVLVQMCK MKAFGELCPN TAPLPQLVTE ALQTGTTEWF HLKQQHHQPM
VQGIPEAGKA LLGLVQDVIG DLHQCQRTWD KIFHNTLKIH LFSMAFRELQ WLVAKRVQDH
TTAVGDAVSP EMGESLFQLY ISLKELYQLR MSSSERDGVL ALDNFHRWFQ PAIPSWLQKT
YNEALARVQR AVQMDELVPL GELTKHSTSA VDLSTCFAQI SHTARQLDWP DPEEAFMITV
KFVEDTCRLA LVYCSLIKAR ARELSSGQKD QGQAANMLCV VVNDMEQLRL VIGKLPAQLA
WEALEQRVGA VLEQGQLQNT LHAQLQSALA GLGHEIRTGV RTLAEQLEVG IAKHIQKLVG
VRESVLPEDA ILPLMKFLEV ELCYMNTNLV QENFSSLLTL LWTHTLTVLV EAAASQRSSS
LASNRLKIAL QNLEICFHAE GCGLPPEALH TATFQALQRD LELQAASSRE LIRKYFCSRI
QQQAETTSEE LGAVTVKASY RASEQKLRVE LLSASSLLPL DSNGSSDPFV QLTLEPRHEF
PELAARETQK HKKDLHPLFD ETFEFLVPAE PCRKAGACLL LTVLDYDTLG ADDLEGEAFL
PLREVPGLSG SEEPGEVPQT RLPLTYPAPN GDPILQLLEG RKGDREAQVF VRLRRHRTKQ
ASQHALRPAP
//
