ID H2QE34_PANTR Unreviewed; 264 AA.
AC H2QE34; A0A2J8JFZ4; K7CXE3;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=Aly/REF export factor {ECO:0000313|Ensembl:ENSPTRP00000016638.5};
DE SubName: Full=THO complex 4 {ECO:0000313|EMBL:JAA31589.1};
GN Name=ALYREF {ECO:0000313|EMBL:JAA31589.1,
GN ECO:0000313|Ensembl:ENSPTRP00000016638.5, ECO:0000313|VGNC:VGNC:6332};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000016638.5, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000016638.5, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|EMBL:JAA31589.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Skin {ECO:0000313|EMBL:JAA31589.1};
RA Maudhoo M.D., Meehan D.T., Norgren R.B.Jr.;
RT "De novo assembly of the reference chimpanzee transcriptome from NextGen
RT mRNA sequences.";
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSPTRP00000016638.5}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AACZ04066982; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; GABD01001511; JAA31589.1; -; mRNA.
DR RefSeq; XP_016786425.1; XM_016930936.1.
DR STRING; 9598.ENSPTRP00000089578; -.
DR PaxDb; 9598-ENSPTRP00000016638; -.
DR Ensembl; ENSPTRT00000017956.5; ENSPTRP00000016638.5; ENSPTRG00000009774.6.
DR GeneID; 744649; -.
DR KEGG; ptr:744649; -.
DR CTD; 10189; -.
DR VGNC; VGNC:6332; ALYREF.
DR eggNOG; KOG0533; Eukaryota.
DR GeneTree; ENSGT00410000025615; -.
DR HOGENOM; CLU_052367_0_1_1; -.
DR OMA; GIARVWF; -.
DR OrthoDB; 1691at2759; -.
DR TreeFam; TF313312; -.
DR Proteomes; UP000002277; Chromosome 17.
DR Bgee; ENSPTRG00000009774; Expressed in testis and 21 other cell types or tissues.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR CDD; cd12680; RRM_THOC4; 1.
DR Gene3D; 3.30.70.330; -; 1.
DR InterPro; IPR025715; FoP_C.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR PANTHER; PTHR19965; RNA AND EXPORT FACTOR BINDING PROTEIN; 1.
DR PANTHER; PTHR19965:SF35; THO COMPLEX SUBUNIT 4; 1.
DR Pfam; PF13865; FoP_duplication; 1.
DR Pfam; PF00076; RRM_1; 1.
DR SMART; SM01218; FoP_duplication; 1.
DR SMART; SM00360; RRM; 1.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 1.
DR PROSITE; PS50102; RRM; 1.
PE 2: Evidence at transcript level;
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU00176}.
FT DOMAIN 113..190
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT REGION 1..93
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 193..264
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 193..207
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 264 AA; 27588 MW; 13AEE38786C9F768 CRC64;
MPDSAPAMAD KMDMSLDDII KLNRSQRGGR GGGRGRGRAG SQGGRGGGAQ AAARVNRGGG
PIRNRPAIAR GAAGGGGRNR PAPYSRPKQL PDKWQHDLFD SGFGGGAGVE TGGKLLVSNL
DFGVSDADIQ ELFAEFGTLK KAAVHYDRSG RSLGTADVHF ERKADALKAM KQYNGVPLDG
RPMNIQLVTS QIDTQRRPAQ SVNRGGMTRN RGAGGFGGGG GTRRGTRGGA RGRGRGAGRN
SKQQLSAEEL DAQLDAYNAR MDTS
//
