ID H2QF95_PANTR Unreviewed; 790 AA.
AC H2QF95; A0A2J8LWS6;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE SubName: Full=Zinc finger protein 560 {ECO:0000313|Ensembl:ENSPTRP00000017761.3};
GN Name=ZNF560 {ECO:0000313|Ensembl:ENSPTRP00000017761.3,
GN ECO:0000313|VGNC:VGNC:2143};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000017761.3, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000017761.3, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000017761.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AACZ04030723; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_009432875.1; XM_009434600.2.
DR RefSeq; XP_524101.2; XM_524101.5.
DR AlphaFoldDB; H2QF95; -.
DR PaxDb; 9598-ENSPTRP00000017761; -.
DR Ensembl; ENSPTRT00000019189.4; ENSPTRP00000017761.3; ENSPTRG00000010442.5.
DR GeneID; 468714; -.
DR KEGG; ptr:468714; -.
DR CTD; 147741; -.
DR VGNC; VGNC:2143; ZNF560.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000164683; -.
DR HOGENOM; CLU_002678_43_0_1; -.
DR InParanoid; H2QF95; -.
DR OMA; EWKMCLK; -.
DR OrthoDB; 4760842at2759; -.
DR TreeFam; TF342172; -.
DR Proteomes; UP000002277; Chromosome 19.
DR Bgee; ENSPTRG00000010442; Expressed in testis and 1 other cell type or tissue.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 2.
DR Gene3D; 6.10.140.140; -; 2.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 15.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR23232; KRAB DOMAIN C2H2 ZINC FINGER; 1.
DR PANTHER; PTHR23232:SF137; ZINC FINGER PROTEIN 8; 1.
DR Pfam; PF01352; KRAB; 2.
DR Pfam; PF00096; zf-C2H2; 9.
DR Pfam; PF13912; zf-C2H2_6; 3.
DR SMART; SM00349; KRAB; 2.
DR SMART; SM00355; ZnF_C2H2; 13.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 9.
DR SUPFAM; SSF109640; KRAB domain (Kruppel-associated box); 2.
DR PROSITE; PS50805; KRAB; 2.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 12.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 14.
PE 4: Predicted;
KW Isopeptide bond {ECO:0000256|ARBA:ARBA00022499};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00042}.
FT DOMAIN 13..84
FT /note="KRAB"
FT /evidence="ECO:0000259|PROSITE:PS50805"
FT DOMAIN 110..181
FT /note="KRAB"
FT /evidence="ECO:0000259|PROSITE:PS50805"
FT DOMAIN 348..375
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 376..403
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 404..431
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 432..459
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 488..515
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 516..543
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 544..571
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 572..599
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 600..627
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 628..655
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 656..683
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 712..739
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 740..767
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 768..790
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
SQ SEQUENCE 790 AA; 91086 MW; AAA553A458AD71B7 CRC64;
MAYCLTNCYQ DSVTFEDTAV DFTQEEWTLL DPVQRNLYRD VMLENYENVA KVGFQLLKPS
VISWLEEEEL RTLQQGVLQD WAIKHQTSVS ALQQDFWKIQ TSNGIQTDLV TFDSVAVEFT
QEEWTLLDPT QRNLYSDVML ENYKNLSSVV YQLFKPSLIS WLEEEEELST LPRVLQEWKM
CLKTNGPALW QDNFCLKTLN GIQLARNQNG EELYDCKQCE DVFCKHTCLK TNMSTQNRGN
TSECIQYAKD LLSLYNNTST IRKVSVFSKH GKSFRLILNV QVQRKCTQDK SFEGTDYGKA
FIHQSNLEAH RKTQSGEKLN EWKQCGEAFT HSTSHAVNVE THIIKNPYEH KECGKDFRYP
THLNNHMQTH IGIKPYKCKH CGKTFTVPSG FLEHVRTHTG EKPYGCKECG KAFGTSAGLI
EHIRCHAREK TFKCDHCGKA FISYSSLFGH LRVHNGEKPY EHKEYEKAFG TSSGVIEDRR
SNTGQKCFDC DQCGKVFVSF SSLFAHLRTH TGEKPFKCYK CGKPFTSSAC LCIHMRTHTE
ERLYQCKKCG KTFTKCSYLT KHLRTHAGEK PYECMTCGKA FTERSYLTKH LRRHSGEKPY
ECKKCGKAFT ERSDLTKHLR RHTGDKPYEY KDRGKAFVVT SRLVDHLRTH TGYKPYKCNA
CEKAYSRSCV LTQHLKTHAA EKTSECNACG NSFRNSMCFH DRLKTLTEIK PYKCKDCGKA
FTCHSDLTNH VRIHTGEKPY KCKECGKAFR TSSGRIQHLR THMGEKPFEC DQCGKAFASF
SARIAHLKTH
//
