ID H2QGN6_PANTR Unreviewed; 142 AA.
AC H2QGN6; A0A2J8K1Q6;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 27-MAR-2024, entry version 85.
DE RecName: Full=AP complex subunit sigma {ECO:0000256|PIRNR:PIRNR015588};
GN Name=AP2S1 {ECO:0000313|EMBL:JAA09940.1,
GN ECO:0000313|Ensembl:ENSPTRP00000019213.3, ECO:0000313|VGNC:VGNC:6612};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000019213.3, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000019213.3, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|EMBL:JAA09940.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Adipose stromal {ECO:0000313|EMBL:JAA09940.1}, Skeletal muscle
RC {ECO:0000313|EMBL:JAA33657.1}, and Skin {ECO:0000313|EMBL:JAA31359.1};
RA Maudhoo M.D., Meehan D.T., Norgren R.B.Jr.;
RT "De novo assembly of the reference chimpanzee transcriptome from NextGen
RT mRNA sequences.";
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSPTRP00000019213.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004370}.
CC -!- SIMILARITY: Belongs to the adaptor complexes small subunit family.
CC {ECO:0000256|ARBA:ARBA00006972, ECO:0000256|PIRNR:PIRNR015588}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AACZ04019593; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; GABC01001398; JAA09940.1; -; mRNA.
DR EMBL; GABD01001741; JAA31359.1; -; mRNA.
DR EMBL; GABE01011082; JAA33657.1; -; mRNA.
DR RefSeq; XP_512774.1; XM_512774.3.
DR PaxDb; 9598-ENSPTRP00000019213; -.
DR Ensembl; ENSPTRT00000020806.4; ENSPTRP00000019213.3; ENSPTRG00000011197.5.
DR GeneID; 456156; -.
DR CTD; 1175; -.
DR VGNC; VGNC:6612; AP2S1.
DR eggNOG; KOG0935; Eukaryota.
DR GeneTree; ENSGT00970000193421; -.
DR HOGENOM; CLU_061221_3_1_1; -.
DR OMA; QSNFVEY; -.
DR OrthoDB; 998051at2759; -.
DR TreeFam; TF300139; -.
DR Proteomes; UP000002277; Chromosome 19.
DR Bgee; ENSPTRG00000011197; Expressed in superior frontal gyrus and 21 other cell types or tissues.
DR GO; GO:0030122; C:AP-2 adaptor complex; IEA:InterPro.
DR GO; GO:0035615; F:clathrin adaptor activity; IEA:InterPro.
DR GO; GO:0072583; P:clathrin-dependent endocytosis; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:UniProtKB-UniRule.
DR CDD; cd14833; AP2_sigma; 1.
DR Gene3D; 3.30.450.60; -; 1.
DR InterPro; IPR016635; AP_complex_ssu.
DR InterPro; IPR022775; AP_mu_sigma_su.
DR InterPro; IPR027156; APS2.
DR InterPro; IPR000804; Clathrin_sm-chain_CS.
DR InterPro; IPR011012; Longin-like_dom_sf.
DR PANTHER; PTHR11753; ADAPTOR COMPLEXES SMALL SUBUNIT FAMILY; 1.
DR PANTHER; PTHR11753:SF6; AP-2 COMPLEX SUBUNIT SIGMA; 1.
DR Pfam; PF01217; Clat_adaptor_s; 1.
DR PIRSF; PIRSF015588; AP_complex_sigma; 1.
DR SUPFAM; SSF64356; SNARE-like; 1.
DR PROSITE; PS00989; CLAT_ADAPTOR_S; 1.
PE 2: Evidence at transcript level;
KW Membrane {ECO:0000256|PIRNR:PIRNR015588};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927,
KW ECO:0000256|PIRNR:PIRNR015588};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW Transport {ECO:0000256|PIRNR:PIRNR015588}.
FT DOMAIN 1..141
FT /note="AP complex mu/sigma subunit"
FT /evidence="ECO:0000259|Pfam:PF01217"
SQ SEQUENCE 142 AA; 17018 MW; CA3FD868C65AEDF6 CRC64;
MIRFILIQNR AGKTRLAKWY MQFDDDEKQK LIEEVHAVVT VRDAKHTNFV EFRNFKIIYR
RYAGLYFCIC VDVNDNNLAY LEAIHNFVEV LNEYFHNVCE LDLVFNFYKV YTVVDEMFLA
GEIRETSQTK VLKQLLMLQS LE
//
