ID H2QJ52_PANTR Unreviewed; 893 AA.
AC H2QJ52; A0A2J8IS49; K7C7R8;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 24-JAN-2024, entry version 75.
DE SubName: Full=PMS1 homolog 1, mismatch repair system component {ECO:0000313|Ensembl:ENSPTRP00000021775.4};
DE SubName: Full=PMS1 postmeiotic segregation increased 1 {ECO:0000313|EMBL:JAA20250.1};
GN Name=PMS1 {ECO:0000313|EMBL:JAA20250.1,
GN ECO:0000313|Ensembl:ENSPTRP00000021775.4, ECO:0000313|VGNC:VGNC:2786};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000021775.4, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000021775.4, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|EMBL:JAA20250.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Smooth vascular {ECO:0000313|EMBL:JAA20250.1};
RA Maudhoo M.D., Meehan D.T., Norgren R.B.Jr.;
RT "De novo assembly of the reference chimpanzee transcriptome from NextGen
RT mRNA sequences.";
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSPTRP00000021775.4}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000256|ARBA:ARBA00006082}.
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DR EMBL; AACZ04058619; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; GABF01001895; JAA20250.1; -; mRNA.
DR RefSeq; XP_016805671.1; XM_016950182.1.
DR Ensembl; ENSPTRT00000023609.4; ENSPTRP00000021775.4; ENSPTRG00000012737.6.
DR GeneID; 459827; -.
DR CTD; 5378; -.
DR VGNC; VGNC:2786; PMS1.
DR eggNOG; KOG1978; Eukaryota.
DR GeneTree; ENSGT00940000157085; -.
DR HOGENOM; CLU_015755_0_0_1; -.
DR OrthoDB; 4698638at2759; -.
DR TreeFam; TF300711; -.
DR Proteomes; UP000002277; Chromosome 2B.
DR Bgee; ENSPTRG00000012737; Expressed in pituitary gland and 21 other cell types or tissues.
DR GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-UniRule.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR CDD; cd16926; HATPase_MutL-MLH-PMS-like; 1.
DR CDD; cd21985; HMG-box_PMS1; 1.
DR CDD; cd03485; MutL_Trans_hPMS_1_like; 1.
DR Gene3D; 1.10.30.10; High mobility group box domain; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR009071; HMG_box_dom.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR InterPro; IPR002099; MutL/Mlh/PMS.
DR InterPro; IPR038973; MutL/Mlh/Pms-like.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR NCBIfam; TIGR00585; mutl; 1.
DR PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR PANTHER; PTHR10073:SF54; PMS1 PROTEIN HOMOLOG 1; 1.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF13589; HATPase_c_3; 1.
DR Pfam; PF00505; HMG_box; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SMART; SM00398; HMG; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF47095; HMG-box; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
DR PROSITE; PS50118; HMG_BOX_2; 1.
PE 2: Evidence at transcript level;
KW DNA-binding {ECO:0000256|PROSITE-ProRule:PRU00267};
KW Nucleus {ECO:0000256|PROSITE-ProRule:PRU00267};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277}.
FT DOMAIN 532..600
FT /note="HMG box"
FT /evidence="ECO:0000259|PROSITE:PS50118"
FT DNA_BIND 532..600
FT /note="HMG box"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00267"
FT REGION 426..454
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 893 AA; 101412 MW; 4D40CEB2CDCA639B CRC64;
MKQLPAATVR LLSSSQIITS VVSVVKELIE NSLDAGATSV DVKLENYGFD KIEVRDNGEG
IKAVDAPVMA MKYYTSKINS HEDLENLTTY GFRGEALGSI CCVAEVLITT RTAADNFSTQ
YVLDGSGRIL SQKPSHLGQG TTVTALRLFK NLPVRKQFYS TAKKCKDEIK KIQDLLMSYG
ILKPDLRIVF VHNKIYLSGF LPKCDADHSF TSLSTPERSF IFINSRPVHQ KDILKLIRHH
YNLKCLKEST RLYPVFFLKI DVPTADVDVN LTPDKSQVLL QNKESVLIAL ENLMTTCYGP
LPSTNSYENN KTDVSAADIV LSKTAETDVL FNKVESSGKN YSNVDTSIIP FQNDMHNDES
GKNTDDCLNH QISIGDFGYG HCSSEISNID KNTKNAFQDI SMSNVSWENS QTEYSKTCFI
SSVKHTQSEN GNKDHIDESG ENEEEAGLEN SSEISADEWS RGNILKNSVG ENIEPVKILV
PEKSLPCKVS NNNYPIPEQM NLNEDSCNKK SNVIDNKSGK VTAYDLLSNR VIKKPMSASA
LFVQDHRPQF LIENPKTSLE DATLQIEELW KTLSEEEKLK YEEKATKDLE RYNSQMKRAI
EQESQMSLKD GRKKIKPTSA WNLAQKHKLK TSLSNQPKLD ELLQSQIEKR RSQNIKMVQI
PFSMKNLKIN FKKQNKVDLE EKDEPCLIHN LRFPDAWLMT SKTEVMLLNP YRVEEALLFK
RLLENHKLPA EPLEKPIMLT ESLFNGSHYL DVLYKMTADD QRYSGSTYLS DPRLTANGFK
IKLIPGVSIT ENYLEIEGMA NCLPFYGVAD LKEILNAILN RNAKEVYECR PRKVISYLEG
EAVRLSRQLP MYLSKEDIQD IIYRMKHQFG NEIKECVHGR PFFHHLTYLP ETT
//