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Database: UniProt
Entry: H2QJ52_PANTR
LinkDB: H2QJ52_PANTR
Original site: H2QJ52_PANTR 
ID   H2QJ52_PANTR            Unreviewed;       893 AA.
AC   H2QJ52; A0A2J8IS49; K7C7R8;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 2.
DT   24-JAN-2024, entry version 75.
DE   SubName: Full=PMS1 homolog 1, mismatch repair system component {ECO:0000313|Ensembl:ENSPTRP00000021775.4};
DE   SubName: Full=PMS1 postmeiotic segregation increased 1 {ECO:0000313|EMBL:JAA20250.1};
GN   Name=PMS1 {ECO:0000313|EMBL:JAA20250.1,
GN   ECO:0000313|Ensembl:ENSPTRP00000021775.4, ECO:0000313|VGNC:VGNC:2786};
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pan.
OX   NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000021775.4, ECO:0000313|Proteomes:UP000002277};
RN   [1] {ECO:0000313|Ensembl:ENSPTRP00000021775.4, ECO:0000313|Proteomes:UP000002277}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16136131; DOI=10.1038/nature04072;
RG   Chimpanzee sequencing and analysis consortium;
RT   "Initial sequence of the chimpanzee genome and comparison with the human
RT   genome.";
RL   Nature 437:69-87(2005).
RN   [2] {ECO:0000313|EMBL:JAA20250.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Smooth vascular {ECO:0000313|EMBL:JAA20250.1};
RA   Maudhoo M.D., Meehan D.T., Norgren R.B.Jr.;
RT   "De novo assembly of the reference chimpanzee transcriptome from NextGen
RT   mRNA sequences.";
RL   Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Ensembl:ENSPTRP00000021775.4}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000256|ARBA:ARBA00006082}.
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DR   EMBL; AACZ04058619; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; GABF01001895; JAA20250.1; -; mRNA.
DR   RefSeq; XP_016805671.1; XM_016950182.1.
DR   Ensembl; ENSPTRT00000023609.4; ENSPTRP00000021775.4; ENSPTRG00000012737.6.
DR   GeneID; 459827; -.
DR   CTD; 5378; -.
DR   VGNC; VGNC:2786; PMS1.
DR   eggNOG; KOG1978; Eukaryota.
DR   GeneTree; ENSGT00940000157085; -.
DR   HOGENOM; CLU_015755_0_0_1; -.
DR   OrthoDB; 4698638at2759; -.
DR   TreeFam; TF300711; -.
DR   Proteomes; UP000002277; Chromosome 2B.
DR   Bgee; ENSPTRG00000012737; Expressed in pituitary gland and 21 other cell types or tissues.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-UniRule.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR   CDD; cd16926; HATPase_MutL-MLH-PMS-like; 1.
DR   CDD; cd21985; HMG-box_PMS1; 1.
DR   CDD; cd03485; MutL_Trans_hPMS_1_like; 1.
DR   Gene3D; 1.10.30.10; High mobility group box domain; 1.
DR   Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR009071; HMG_box_dom.
DR   InterPro; IPR036910; HMG_box_dom_sf.
DR   InterPro; IPR002099; MutL/Mlh/PMS.
DR   InterPro; IPR038973; MutL/Mlh/Pms-like.
DR   InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR   NCBIfam; TIGR00585; mutl; 1.
DR   PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR   PANTHER; PTHR10073:SF54; PMS1 PROTEIN HOMOLOG 1; 1.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF13589; HATPase_c_3; 1.
DR   Pfam; PF00505; HMG_box; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00398; HMG; 1.
DR   SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR   SUPFAM; SSF47095; HMG-box; 1.
DR   SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
DR   PROSITE; PS50118; HMG_BOX_2; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding {ECO:0000256|PROSITE-ProRule:PRU00267};
KW   Nucleus {ECO:0000256|PROSITE-ProRule:PRU00267};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002277}.
FT   DOMAIN          532..600
FT                   /note="HMG box"
FT                   /evidence="ECO:0000259|PROSITE:PS50118"
FT   DNA_BIND        532..600
FT                   /note="HMG box"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00267"
FT   REGION          426..454
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   893 AA;  101412 MW;  4D40CEB2CDCA639B CRC64;
     MKQLPAATVR LLSSSQIITS VVSVVKELIE NSLDAGATSV DVKLENYGFD KIEVRDNGEG
     IKAVDAPVMA MKYYTSKINS HEDLENLTTY GFRGEALGSI CCVAEVLITT RTAADNFSTQ
     YVLDGSGRIL SQKPSHLGQG TTVTALRLFK NLPVRKQFYS TAKKCKDEIK KIQDLLMSYG
     ILKPDLRIVF VHNKIYLSGF LPKCDADHSF TSLSTPERSF IFINSRPVHQ KDILKLIRHH
     YNLKCLKEST RLYPVFFLKI DVPTADVDVN LTPDKSQVLL QNKESVLIAL ENLMTTCYGP
     LPSTNSYENN KTDVSAADIV LSKTAETDVL FNKVESSGKN YSNVDTSIIP FQNDMHNDES
     GKNTDDCLNH QISIGDFGYG HCSSEISNID KNTKNAFQDI SMSNVSWENS QTEYSKTCFI
     SSVKHTQSEN GNKDHIDESG ENEEEAGLEN SSEISADEWS RGNILKNSVG ENIEPVKILV
     PEKSLPCKVS NNNYPIPEQM NLNEDSCNKK SNVIDNKSGK VTAYDLLSNR VIKKPMSASA
     LFVQDHRPQF LIENPKTSLE DATLQIEELW KTLSEEEKLK YEEKATKDLE RYNSQMKRAI
     EQESQMSLKD GRKKIKPTSA WNLAQKHKLK TSLSNQPKLD ELLQSQIEKR RSQNIKMVQI
     PFSMKNLKIN FKKQNKVDLE EKDEPCLIHN LRFPDAWLMT SKTEVMLLNP YRVEEALLFK
     RLLENHKLPA EPLEKPIMLT ESLFNGSHYL DVLYKMTADD QRYSGSTYLS DPRLTANGFK
     IKLIPGVSIT ENYLEIEGMA NCLPFYGVAD LKEILNAILN RNAKEVYECR PRKVISYLEG
     EAVRLSRQLP MYLSKEDIQD IIYRMKHQFG NEIKECVHGR PFFHHLTYLP ETT
//
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