ID H2QJP3_PANTR Unreviewed; 480 AA.
AC H2QJP3; A0A2J8JQ23;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=Melanophilin {ECO:0000313|Ensembl:ENSPTRP00000022370.4};
GN Name=MLPH {ECO:0000313|Ensembl:ENSPTRP00000022370.4,
GN ECO:0000313|VGNC:VGNC:14155};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000022370.4, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000022370.4, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000022370.4}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AACZ04056664; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H2QJP3; -.
DR Ensembl; ENSPTRT00000024249.4; ENSPTRP00000022370.4; ENSPTRG00000013075.6.
DR VGNC; VGNC:14155; MLPH.
DR eggNOG; ENOG502RJPZ; Eukaryota.
DR GeneTree; ENSGT00950000183138; -.
DR HOGENOM; CLU_025193_0_0_1; -.
DR TreeFam; TF331599; -.
DR Proteomes; UP000002277; Chromosome 2B.
DR Bgee; ENSPTRG00000013075; Expressed in heart and 12 other cell types or tissues.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR CDD; cd15752; FYVE_SlaC2-a; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR041282; FYVE_2.
DR InterPro; IPR037442; Melanophilin_FYVE-rel_dom.
DR InterPro; IPR010911; Rab_BD.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR14555:SF1; MELANOPHILIN; 1.
DR PANTHER; PTHR14555; MYELIN-ASSOCIATED OLIGODENDROCYTIC BASIC PROTEIN MOBP -RELATED; 1.
DR Pfam; PF02318; FYVE_2; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR PROSITE; PS50916; RABBD; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002277}.
FT DOMAIN 4..124
FT /note="RabBD"
FT /evidence="ECO:0000259|PROSITE:PS50916"
FT REGION 143..235
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 282..362
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 381..421
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 433..480
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 177..191
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 192..206
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 214..230
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 308..325
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 334..349
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 434..449
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 450..464
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 480 AA; 52531 MW; 420B45E3DD230506 CRC64;
MGKKLDLSKL TDEEAQHVLE VVQRDFDLRR KEEERLEGLK GKIKKESSKR ELLSDTAHLN
ETHCAHCLQP YRLLVNSKRQ CLECGLFTCK SCGRVHPEEQ GWICDPCHLA RVVKIGSLEW
YYEHVKARFK RFGSAKVIRS LHGRLQGGAG PEPISEERSG DSDQTDEDGE PDSEAQAQAQ
PFGSKSLTDE SCSEKAAPHK TEGLEEADTG ASGCQSHPEE QPTSILPSGH STLAELCPPG
GSHRMALGTA AALGSNVIRN EQLPLQYLAD VDTSDEESIR AHVMASHHSK RRGRASSESQ
GLGAGVRTEA DVEEEALRRK LEELTSNVSD QGTSSEEEEA KDEKAEPNRG KSVGALPQAD
PEVSDIESRI AALRAAGLTV KPSGKPRRKS NLPIFLPRVA GKLGKRPEDP NADPSSEAKA
MAVPYLLRRK FSNSLKSQGK DDDSFDRKSV YRGSLTQRNP NARKGMASHT FAKPVVAHQS
//
