ID H2QKU4_PANTR Unreviewed; 334 AA.
AC H2QKU4; A0A2J8KNE2; K7C7M0;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 75.
DE SubName: Full=Protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2 {ECO:0000313|EMBL:JAA12241.1, ECO:0000313|Ensembl:ENSPTRP00000023735.4};
GN Name=PCMTD2 {ECO:0000313|EMBL:JAA12241.1,
GN ECO:0000313|Ensembl:ENSPTRP00000023735.4,
GN ECO:0000313|VGNC:VGNC:14276};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000023735.4, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000023735.4, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|EMBL:JAA12241.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Skeletal muscle {ECO:0000313|EMBL:JAA38556.1}, Skin
RC {ECO:0000313|EMBL:JAA24082.1}, and Smooth vascular
RC {ECO:0000313|EMBL:JAA12241.1};
RA Maudhoo M.D., Meehan D.T., Norgren R.B.Jr.;
RT "De novo assembly of the reference chimpanzee transcriptome from NextGen
RT mRNA sequences.";
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSPTRP00000023735.4}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the methyltransferase superfamily. L-
CC isoaspartyl/D-aspartyl protein methyltransferase family.
CC {ECO:0000256|ARBA:ARBA00005369}.
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DR EMBL; AACZ04002187; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; GABF01009904; JAA12241.1; -; mRNA.
DR EMBL; GABD01009018; JAA24082.1; -; mRNA.
DR EMBL; GABE01006183; JAA38556.1; -; mRNA.
DR RefSeq; XP_003317122.1; XM_003317074.4.
DR RefSeq; XP_009435975.1; XM_009437700.2.
DR Ensembl; ENSPTRT00000025709.4; ENSPTRP00000023735.4; ENSPTRG00000013773.7.
DR GeneID; 100610149; -.
DR CTD; 55251; -.
DR VGNC; VGNC:14276; PCMTD2.
DR eggNOG; KOG1661; Eukaryota.
DR GeneTree; ENSGT00950000183032; -.
DR HOGENOM; CLU_029295_0_0_1; -.
DR OrthoDB; 55859at2759; -.
DR TreeFam; TF329329; -.
DR Proteomes; UP000002277; Chromosome 20.
DR Bgee; ENSPTRG00000013773; Expressed in Brodmann (1909) area 10 and 20 other cell types or tissues.
DR GO; GO:0004719; F:protein-L-isoaspartate (D-aspartate) O-methyltransferase activity; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0036211; P:protein modification process; IEA:InterPro.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR000682; PCMT.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR11579; PROTEIN-L-ISOASPARTATE O-METHYLTRANSFERASE; 1.
DR PANTHER; PTHR11579:SF2; PROTEIN-L-ISOASPARTATE O-METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN 2; 1.
DR Pfam; PF01135; PCMT; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE 2: Evidence at transcript level;
KW Methyltransferase {ECO:0000313|EMBL:JAA12241.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW Transferase {ECO:0000313|EMBL:JAA12241.1}.
FT REGION 276..309
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 334 AA; 38119 MW; 22C856548611940C CRC64;
MGGAVSAGED NDELIDNLKE AQYIRTELVE QAFRAIDRAD YYLEEFKENA YKDLAWKHGN
IHLSAPCIYS EVMEALDLQP GLSFLNLGSG TGYLSSMVGL ILGPFGVNHG VELHSDVIEY
AKQKLDFFIR TSDSFDKFDF CEPSFVTGNC LEISPDCSQY DRVYCGAGVQ KEHEEYMKNL
LKVGGILVMP LEEKPCHSES GKSRLVQLPP VAVRSLQDLA RIAIRGTIKK IIHQETVSKN
GNGLKNTPRF KRRRVRRRRM ETIVFLDKEV FASRISNPSD DNSCEDLEEE RREEEEKTPP
ETKPDPPVNF LRQKVLSLPL PDPLKYYLLY YREK
//
