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Database: UniProt
Entry: H2QL16_PANTR
LinkDB: H2QL16_PANTR
Original site: H2QL16_PANTR 
ID   H2QL16_PANTR            Unreviewed;      2012 AA.
AC   H2QL16; A0A2J8M822;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   05-JUN-2019, entry version 56.
DE   SubName: Full=DS cell adhesion molecule {ECO:0000313|Ensembl:ENSPTRP00000023956};
DE   SubName: Full=DSCAM isoform 1 {ECO:0000313|EMBL:PNI55670.1};
GN   Name=DSCAM {ECO:0000313|Ensembl:ENSPTRP00000023956,
GN   ECO:0000313|VGNC:VGNC:1152};
GN   ORFNames=CK820_G0022830 {ECO:0000313|EMBL:PNI55670.1};
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Pan.
OX   NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000023956, ECO:0000313|Proteomes:UP000002277};
RN   [1] {ECO:0000313|Ensembl:ENSPTRP00000023956, ECO:0000313|Proteomes:UP000002277}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16136131; DOI=10.1038/nature04072;
RG   Chimpanzee sequencing and analysis consortium;
RT   "Initial sequence of the chimpanzee genome and comparison with the
RT   human genome.";
RL   Nature 437:69-87(2005).
RN   [2] {ECO:0000313|Ensembl:ENSPTRP00000023956, ECO:0000313|Proteomes:UP000002277}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16136134; DOI=10.1038/nature04101;
RA   Hughes J.F., Skaletsky H., Pyntikova T., Minx P.J., Graves T.,
RA   Rozen S., Wilson R.K., Page D.C.;
RT   "Conservation of Y-linked genes during human evolution revealed by
RT   comparative sequencing in chimpanzee.";
RL   Nature 437:100-103(2005).
RN   [3] {ECO:0000313|Ensembl:ENSPTRP00000023956}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
RN   [4] {ECO:0000313|EMBL:PNI55670.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Yerkes chimp pedigree #C0471 {ECO:0000313|EMBL:PNI55670.1};
RC   TISSUE=Blood {ECO:0000313|EMBL:PNI55670.1};
RA   Pollen A., Hastie A., Hormozdiari F., Dougherty M., Liu R.,
RA   Chaisson M., Hoppe E., Hill C., Pang A., Hillier L., Baker C.,
RA   Armstrong J., Shendure J., Paten B., Wilson R., Chao H., Schneider V.,
RA   Ventura M., Kronenberg Z., Murali S., Gordon D., Cantsilieris S.,
RA   Munson K., Nelson B., Raja A., Underwood J., Diekhans M., Fiddes I.,
RA   Haussler D., Eichler E.;
RT   "High-resolution comparative analysis of great ape genomes.";
RL   Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; AACZ04064325; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AACZ04064326; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AACZ04064327; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AACZ04064328; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AACZ04064329; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AACZ04064330; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; NBAG03000265; PNI55670.1; -; Genomic_DNA.
DR   SMR; H2QL16; -.
DR   STRING; 9598.ENSPTRP00000023956; -.
DR   PaxDb; H2QL16; -.
DR   Ensembl; ENSPTRT00000025965; ENSPTRP00000023956; ENSPTRG00000013922.
DR   VGNC; VGNC:1152; DSCAM.
DR   eggNOG; ENOG410KD5V; Eukaryota.
DR   eggNOG; ENOG410XQX7; LUCA.
DR   GeneTree; ENSGT00940000154678; -.
DR   InParanoid; H2QL16; -.
DR   TreeFam; TF316846; -.
DR   Proteomes; UP000002277; Chromosome 21.
DR   Bgee; ENSPTRG00000013922; Expressed in 3 organ(s), highest expression level in prefrontal cortex.
DR   GO; GO:0030424; C:axon; IBA:GO_Central.
DR   GO; GO:0030425; C:dendrite; IEA:Ensembl.
DR   GO; GO:0030426; C:growth cone; IEA:Ensembl.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:InterPro.
DR   GO; GO:0043025; C:neuronal cell body; IEA:Ensembl.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0098632; F:cell-cell adhesion mediator activity; IBA:GO_Central.
DR   GO; GO:1990890; F:netrin receptor binding; IEA:Ensembl.
DR   GO; GO:1990782; F:protein tyrosine kinase binding; IEA:Ensembl.
DR   GO; GO:0007411; P:axon guidance; IBA:GO_Central.
DR   GO; GO:0048813; P:dendrite morphogenesis; IEA:Ensembl.
DR   GO; GO:0070593; P:dendrite self-avoidance; IBA:GO_Central.
DR   GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IBA:GO_Central.
DR   GO; GO:0007626; P:locomotory behavior; IEA:Ensembl.
DR   GO; GO:0007162; P:negative regulation of cell adhesion; IEA:Ensembl.
DR   GO; GO:0048842; P:positive regulation of axon extension involved in axon guidance; IEA:Ensembl.
DR   GO; GO:0042327; P:positive regulation of phosphorylation; IEA:Ensembl.
DR   GO; GO:0060060; P:post-embryonic retina morphogenesis in camera-type eye; IEA:Ensembl.
DR   CDD; cd00063; FN3; 6.
DR   Gene3D; 2.60.40.10; -; 16.
DR   InterPro; IPR033027; DSCAM_chordates.
DR   InterPro; IPR003961; FN3_dom.
DR   InterPro; IPR036116; FN3_sf.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR013098; Ig_I-set.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR003598; Ig_sub2.
DR   InterPro; IPR013106; Ig_V-set.
DR   PANTHER; PTHR10075:SF51; PTHR10075:SF51; 1.
DR   Pfam; PF00041; fn3; 5.
DR   Pfam; PF07679; I-set; 5.
DR   SMART; SM00060; FN3; 6.
DR   SMART; SM00409; IG; 9.
DR   SMART; SM00408; IGc2; 9.
DR   SMART; SM00406; IGv; 3.
DR   SUPFAM; SSF48726; SSF48726; 9.
DR   SUPFAM; SSF49265; SSF49265; 3.
DR   PROSITE; PS50853; FN3; 6.
DR   PROSITE; PS50835; IG_LIKE; 9.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002277};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW   Repeat {ECO:0000256|SAAS:SAAS00923712};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     17       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        18   2012       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5015092837.
FT   TRANSMEM   1595   1616       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      125    216       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      225    305       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      313    401       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      407    500       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      504    592       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      596    685       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      690    783       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      787    883       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      885    982       Fibronectin type-III.
FT                                {ECO:0000259|PROSITE:PS50853}.
FT   DOMAIN      987   1086       Fibronectin type-III.
FT                                {ECO:0000259|PROSITE:PS50853}.
FT   DOMAIN     1091   1187       Fibronectin type-III.
FT                                {ECO:0000259|PROSITE:PS50853}.
FT   DOMAIN     1191   1285       Fibronectin type-III.
FT                                {ECO:0000259|PROSITE:PS50853}.
FT   DOMAIN     1285   1377       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN     1379   1473       Fibronectin type-III.
FT                                {ECO:0000259|PROSITE:PS50853}.
FT   DOMAIN     1474   1575       Fibronectin type-III.
FT                                {ECO:0000259|PROSITE:PS50853}.
FT   REGION     1718   1810       Disordered. {ECO:0000256|MobiDB-lite:
FT                                H2QL16}.
FT   REGION     1855   1883       Disordered. {ECO:0000256|MobiDB-lite:
FT                                H2QL16}.
FT   REGION     1971   2012       Disordered. {ECO:0000256|MobiDB-lite:
FT                                H2QL16}.
FT   COMPBIAS   1725   1767       Polar. {ECO:0000256|MobiDB-lite:H2QL16}.
FT   COMPBIAS   1782   1810       Polar. {ECO:0000256|MobiDB-lite:H2QL16}.
FT   COMPBIAS   1855   1869       Polar. {ECO:0000256|MobiDB-lite:H2QL16}.
FT   COMPBIAS   1982   1996       Polar. {ECO:0000256|MobiDB-lite:H2QL16}.
SQ   SEQUENCE   2012 AA;  222260 MW;  0E33CFB781A08334 CRC64;
     MWILALSLFQ SFANVFSEDL HSSLYFVNAS LQEVVFASTT GTLVPCPAAG IPPVTLRWYL
     ATGEEIYDVP GIRHVHPNGT LQIFPFPPSS FSTLIHDNTY YCTAENPSGK IRSQDVHIKA
     VLREPYTVRV EDQKTMRGNV AVFKCIIPSS VEAYITVVSW EKDTVSLVSG SRFLITSTGA
     LYIKDVQNED GLYNYRCITR HRYTGETRQS NSARLFVSDP ANSAPSILDG FDHRKAMAGQ
     RVELPCKALG HPEPDYRWLK DNMPLELSGR FQKTVTGLLI ENIRPSDSGS YVCEVSNRYG
     TAKVIGRLYV KQPLKATISP RKVKSSVGSQ VSLSCSVTGT EDQELSWYRN GEILNPGKNV
     RITGINHENL IMDHMVKSDG GAYQCFVRKD KLSAQDYVQV VLEDGTPKII SAFSEKVVSP
     AEPVSLMCNV KGTPLPTITW TLDDDPILKG GSHRISQMIT SEGNVVSYLN ISSSQVRDGG
     VYRCTANNSA GVVLYQARIN VRGPASIRPM KNITAIAGRD TYIHCRVIGY PYYSIKWYKN
     SNLLPFNHRQ VAFENNGTLK LSDVQKEVDE GEYTCNVLVQ PQLSTSQSVH VTVKVPPFIQ
     PFEFPRFSIG QRVFIPCVVV SGDLPITITW QKDGRPIPGS LGVTIDNIDF TSSLRISNLS
     LMHNGNYTCI ARNEAAAVEH QSQLIVRVPP KFVVQPRDQD GIYGKAVILN CSAEGYPVPT
     IVWKFSKGAG VPQFQPIALN GRIQVLSNGS LLIKHVVEED SGYYLCKVSN DVGADVSKSM
     YLTVKIPAMI TSYPNTTLAT QGQKKEMSCT AHGEKPIIVR WEKEDRIINP EMARYLVSTK
     EVGEEVISTL QILPTVREDS GFFSCHAINS YGEDRGIIQL TVQEPPDPPE IEIKDVKART
     ITLRWTMGFD GNSPITGYDI ECKNKSDSWD SAQRTKDVSP QLNSATIIDI HPSSTYSIRM
     YAKNRIGKSE PSNELTITAD EAAPDGPPQE VHLEPISSQS IRVTWKAPKK HLQNGIIRGY
     QIGYREYSTG GNFQFNIISV DTSGDSEVYT LDNLNKFTQY GLVVQACNRA GTGPSSQEII
     TTTLEDVPSY PPENVQAIAT SPESISISWS TLSKEALNGI LQGFRVIYWA NLMDGELGEI
     KNITTTQPSL ELDGLEKYTN YSIQVLAFTR AGDGVRSEQI FTRTKEDVPG PPAGVKAAAA
     SASMVFVSWL PPLKLNGIIR KYTVFCSHPY PTVISEFEAS PDSFSYRIPN LSRNRQYSVW
     VVAVTSAGRG NSSEIITVEP LAKAPARILT FSGTVTTPWM KDIVLPCKAV GDPSPAVKWM
     KDSNGTPSLV TIDGRRSIFS NGSFIIRTVK AEDSGYYSCI ANNNWGSDEI ILNLQVQVPP
     DQPRLTVSKT TSSSITLSWL PGDNGGSSIR GYILQYSEDN SEQWGSFPIS PSERSYRLEN
     LKCGTWYKFT LTAQNGVGPG RISEIIEAKT LGKEPQFSKE QELFASINTT RVRLNLIGWN
     DGGCPITSFT LEYRPFGTTV WTTAQRTSLS KSYILYDLQE ATWYELQMRV CNSAGCAEKQ
     ANFATLNYDG STIPPLIKSV VQNEEGLTTN EGLKMLVTIS CILVGVLLLF VLLLVVRRRR
     REQRLKRLRD AKSLAEMLMS KNTRTSDTLS KQQQTLRMHI DIPRAQLLIE ERDTMETIDD
     RSTVLLTDAD FGEAAKQKSL TVTHTVHYQS VSQATGPLVD VSDARPGTNP TTRRNAKAGP
     TARNRYASQW TLNRPHPTIS AHTLTTDWRL PTPRAAGSVD KESDSYSVSP SQDTDRARSS
     MVSTESASST YEELARAYEH AKMEEQLRHA KFTITECFIS DTSSEQLTAG TNEYTDSLTS
     STPSESGICR FTASPPKPQD GGRVMNMAVP KAHRPGDLIH LPPYLRMDFL LNRGGPGTSR
     DLSLGQACLE PQKSRTLKRP TVLEPIPMEA ASSASSTREG QSWQPGAVAT LPQREGAELG
     QAAKMSSSQE SLLDSRGHLK GNNPYAKSYT LV
//
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