ID H2QLL2_PANTR Unreviewed; 297 AA.
AC H2QLL2; A0A2J8QPK5;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE RecName: Full=Sulfurtransferase {ECO:0000256|RuleBase:RU000507};
GN Name=TST {ECO:0000313|EMBL:JAA12331.1,
GN ECO:0000313|Ensembl:ENSPTRP00000024667.1, ECO:0000313|VGNC:VGNC:6714};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000024667.1, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000024667.1, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164055; DOI=10.1038/nature02564;
RA Watanabe H., Fujiyama A., Hattori M., Taylor T.D., Toyoda A., Kuroki Y.,
RA Noguchi H., BenKahla A., Lehrach H., Sudbrak R., Kube M., Taenzer S.,
RA Galgoczy P., Platzer M., Scharfe M., Nordsiek G., Bloecker H., Hellmann I.,
RA Khaitovich P., Paabo S., Reinhardt R., Zheng H.-J., Zhang X.-L., Zhu G.-F.,
RA Wang B.-F., Fu G., Ren S.-X., Zhao G.-P., Chen Z., Lee Y.-S., Cheong J.-E.,
RA Choi S.-H., Wu K.-M., Liu T.-T., Hsiao K.-J., Tsai S.-F., Kim C.-G.,
RA Oota S., Kitano T., Kohara Y., Saitou N., Park H.-S., Wang S.-Y.,
RA Yaspo M.-L., Sakaki Y.;
RT "DNA sequence and comparative analysis of chimpanzee chromosome 22.";
RL Nature 429:382-388(2004).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000024667.1, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [3] {ECO:0000313|EMBL:JAA12331.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Skeletal muscle {ECO:0000313|EMBL:JAA34846.1}, and Smooth
RC vascular {ECO:0000313|EMBL:JAA12331.1};
RA Maudhoo M.D., Meehan D.T., Norgren R.B.Jr.;
RT "De novo assembly of the reference chimpanzee transcriptome from NextGen
RT mRNA sequences.";
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|Ensembl:ENSPTRP00000024667.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=hydrogen cyanide + thiosulfate = 2 H(+) + sulfite +
CC thiocyanate; Xref=Rhea:RHEA:16881, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:17359, ChEBI:CHEBI:18022, ChEBI:CHEBI:18407,
CC ChEBI:CHEBI:33542; EC=2.8.1.1;
CC Evidence={ECO:0000256|ARBA:ARBA00000653};
CC -!- SUBUNIT: Monomer. {ECO:0000256|ARBA:ARBA00011245}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion matrix
CC {ECO:0000256|ARBA:ARBA00004305}.
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DR EMBL; AACZ04068053; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; GABF01009814; JAA12331.1; -; mRNA.
DR EMBL; GABE01009893; JAA34846.1; -; mRNA.
DR RefSeq; XP_001159859.1; XM_001159859.4.
DR STRING; 9598.ENSPTRP00000024667; -.
DR PaxDb; 9598-ENSPTRP00000024667; -.
DR Ensembl; ENSPTRT00000026763.2; ENSPTRP00000024667.1; ENSPTRG00000014323.3.
DR GeneID; 458803; -.
DR KEGG; ptr:458803; -.
DR CTD; 7263; -.
DR VGNC; VGNC:6714; TST.
DR eggNOG; KOG1529; Eukaryota.
DR GeneTree; ENSGT00510000046773; -.
DR HOGENOM; CLU_031618_3_1_1; -.
DR OMA; YPRVKGY; -.
DR OrthoDB; 5488838at2759; -.
DR TreeFam; TF315133; -.
DR Proteomes; UP000002277; Chromosome 22.
DR Bgee; ENSPTRG00000014323; Expressed in liver and 18 other cell types or tissues.
DR GO; GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
DR GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR GO; GO:0008097; F:5S rRNA binding; IEA:Ensembl.
DR GO; GO:0004792; F:thiosulfate sulfurtransferase activity; IBA:GO_Central.
DR GO; GO:0030855; P:epithelial cell differentiation; IEA:Ensembl.
DR GO; GO:0035928; P:rRNA import into mitochondrion; IEA:Ensembl.
DR CDD; cd01449; TST_Repeat_2; 1.
DR CDD; cd01445; TST_Repeats; 1.
DR Gene3D; 3.40.250.10; Rhodanese-like domain; 2.
DR InterPro; IPR001763; Rhodanese-like_dom.
DR InterPro; IPR036873; Rhodanese-like_dom_sf.
DR InterPro; IPR001307; Thiosulphate_STrfase_CS.
DR InterPro; IPR045078; TST/MPST-like.
DR PANTHER; PTHR11364; THIOSULFATE SULFERTANSFERASE; 1.
DR PANTHER; PTHR11364:SF6; THIOSULFATE SULFURTRANSFERASE; 1.
DR Pfam; PF00581; Rhodanese; 2.
DR SMART; SM00450; RHOD; 2.
DR SUPFAM; SSF52821; Rhodanese/Cell cycle control phosphatase; 2.
DR PROSITE; PS00380; RHODANESE_1; 1.
DR PROSITE; PS00683; RHODANESE_2; 1.
DR PROSITE; PS50206; RHODANESE_3; 2.
PE 2: Evidence at transcript level;
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transferase {ECO:0000256|RuleBase:RU000507, ECO:0000313|EMBL:JAA12331.1}.
FT DOMAIN 25..143
FT /note="Rhodanese"
FT /evidence="ECO:0000259|PROSITE:PS50206"
FT DOMAIN 173..288
FT /note="Rhodanese"
FT /evidence="ECO:0000259|PROSITE:PS50206"
SQ SEQUENCE 297 AA; 33443 MW; 229B6FA107FAA215 CRC64;
MVHQVLYRAL VSTKWLAESI RTGKLGPGLR VLDASWYSPG TREARKEYLE RHVPGASFFD
IEECRDTASP YEMMLPSEAG FAEYVGRLGI SNHTHVVVYD GDHLGSFYAP RVWWMFRVFG
HRTVSVLNGG FRNWLKEGHP VTSEPSRPEP AVFKATLDRS LLKTYEQVLE NLESKRFQLV
DSRSQGRFLG TEPEPDAVGL DSGHIRGAVN MPFMDFLTED GFEKGPEELR ALFQTKKVDL
SQPLIATCRK GVTACHVALA AYLCGKPDVA VYDGSWSEWF RRAPPESRVS QGRSEKA
//
