ID H2QLW8_PANTR Unreviewed; 565 AA.
AC H2QLW8;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 43.
DE SubName: Full=GRAM domain containing 4 {ECO:0000313|Ensembl:ENSPTRP00000025021.4};
GN Name=GRAMD4 {ECO:0000313|Ensembl:ENSPTRP00000025021.4,
GN ECO:0000313|VGNC:VGNC:5266};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000025021.4, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000025021.4, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164055; DOI=10.1038/nature02564;
RA Watanabe H., Fujiyama A., Hattori M., Taylor T.D., Toyoda A., Kuroki Y.,
RA Noguchi H., BenKahla A., Lehrach H., Sudbrak R., Kube M., Taenzer S.,
RA Galgoczy P., Platzer M., Scharfe M., Nordsiek G., Bloecker H., Hellmann I.,
RA Khaitovich P., Paabo S., Reinhardt R., Zheng H.-J., Zhang X.-L., Zhu G.-F.,
RA Wang B.-F., Fu G., Ren S.-X., Zhao G.-P., Chen Z., Lee Y.-S., Cheong J.-E.,
RA Choi S.-H., Wu K.-M., Liu T.-T., Hsiao K.-J., Tsai S.-F., Kim C.-G.,
RA Oota S., Kitano T., Kohara Y., Saitou N., Park H.-S., Wang S.-Y.,
RA Yaspo M.-L., Sakaki Y.;
RT "DNA sequence and comparative analysis of chimpanzee chromosome 22.";
RL Nature 429:382-388(2004).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000025021.4, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [3] {ECO:0000313|Ensembl:ENSPTRP00000025021.4}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AACZ04059360; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H2QLW8; -.
DR PaxDb; 9598-ENSPTRP00000025021; -.
DR Ensembl; ENSPTRT00000027139.4; ENSPTRP00000025021.4; ENSPTRG00000014513.4.
DR VGNC; VGNC:5266; GRAMD4.
DR eggNOG; ENOG502QPMR; Eukaryota.
DR GeneTree; ENSGT00390000010968; -.
DR HOGENOM; CLU_028241_0_0_1; -.
DR TreeFam; TF320445; -.
DR Proteomes; UP000002277; Chromosome 22.
DR Bgee; ENSPTRG00000014513; Expressed in heart and 21 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0006915; P:apoptotic process; IEA:InterPro.
DR CDD; cd13221; PH-GRAM_GRAMDC4; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR004182; GRAM.
DR InterPro; IPR037847; GRAMDC4.
DR InterPro; IPR037845; GRAMDC4_PH-GRAM.
DR InterPro; IPR011993; PH-like_dom_sf.
DR PANTHER; PTHR37402; GRAM DOMAIN-CONTAINING PROTEIN 4; 1.
DR PANTHER; PTHR37402:SF1; GRAM DOMAIN-CONTAINING PROTEIN 4; 1.
DR Pfam; PF02893; GRAM; 1.
DR SMART; SM00568; GRAM; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 233..255
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 432..510
FT /note="GRAM"
FT /evidence="ECO:0000259|SMART:SM00568"
FT REGION 123..146
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 402..422
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 71..121
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 128..146
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 565 AA; 64758 MW; E74672C04E87E8D3 CRC64;
MSEPPSWGRL APGVFWRHLR LELPGSAWSP RPMSPVYARA QAGPGTLIMA TGVQDFNRTE
FDRLNEIKGH LEIALLEKHF LQEELRKLRE ETNAEMLRQE LDRERQRRME LEQKVQEVLK
ARTEEQMAQQ PPKGQAQASN GAERRSQGLS SRLQKWFYER FGEYVEDFRF QPEENTVETE
EPLSARRLTE NMRRLKRGAK PVTNFVKNLS ALSDWYSVYT SAIAFTVYMN AVWHGWAIPL
FLFLAILRLS LNYLIARGWR IQWSIVPEVS EPVEPPKEDL TVSEKFQLVL DVAQKAQNLF
GKMADILEKI KNLFMWVQPE ITQKLYVALW AAFLASCFFP YRLVGLAVGL YAGIKFFLID
FIFKRCPRLR AKYDTPYIIW RSLPTDPQLK ERSSAAVSRR LQTTSSRSYV PSAPAGLGKE
EDAGRFHSTK KGNFHEIFNL TENERPLAVC ENGWRCCLIN RDRKMPTDYI RNGVLYVTEN
YLCFESSKSG SSKRNKVIKL VDITDIQKYK VLSVLPGSGM GIAVSTPSTQ KPLVFGAMVH
RDEAFETILS QYIKITSAAA SGGDS
//
