ID H2QPQ3_PANTR Unreviewed; 94 AA.
AC H2QPQ3; A0A2J8PFR2;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 27-MAR-2024, entry version 80.
DE RecName: Full=C-X-C motif chemokine {ECO:0000256|RuleBase:RU361149};
GN Name=CXCL11 {ECO:0000313|EMBL:JAA00546.1,
GN ECO:0000313|Ensembl:ENSPTRP00000027808.3, ECO:0000313|VGNC:VGNC:8660};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000027808.3, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000027808.3, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|EMBL:JAA00546.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Adipose stromal {ECO:0000313|EMBL:JAA00546.1};
RA Maudhoo M.D., Meehan D.T., Norgren R.B.Jr.;
RT "De novo assembly of the reference chimpanzee transcriptome from NextGen
RT mRNA sequences.";
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSPTRP00000027808.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613,
CC ECO:0000256|RuleBase:RU361149}.
CC -!- SIMILARITY: Belongs to the intercrine alpha (chemokine CxC) family.
CC {ECO:0000256|ARBA:ARBA00010665, ECO:0000256|RuleBase:RU361149}.
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DR EMBL; AACZ04033858; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; GABC01010792; JAA00546.1; -; mRNA.
DR RefSeq; XP_001151687.1; XM_001151687.4.
DR RefSeq; XP_009445989.1; XM_009447714.1.
DR RefSeq; XP_016807063.1; XM_016951574.1.
DR STRING; 9598.ENSPTRP00000027808; -.
DR PaxDb; 9598-ENSPTRP00000027808; -.
DR Ensembl; ENSPTRT00000030123.4; ENSPTRP00000027808.3; ENSPTRG00000016183.4.
DR GeneID; 739195; -.
DR KEGG; ptr:739195; -.
DR CTD; 6373; -.
DR VGNC; VGNC:8660; CXCL11.
DR eggNOG; ENOG502SGFE; Eukaryota.
DR GeneTree; ENSGT00530000064263; -.
DR HOGENOM; CLU_143902_2_3_1; -.
DR OMA; ANKGQRC; -.
DR TreeFam; TF333433; -.
DR Proteomes; UP000002277; Chromosome 4.
DR Bgee; ENSPTRG00000016183; Expressed in liver and 11 other cell types or tissues.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0008009; F:chemokine activity; IBA:GO_Central.
DR GO; GO:0045236; F:CXCR chemokine receptor binding; IBA:GO_Central.
DR GO; GO:0048248; F:CXCR3 chemokine receptor binding; IEA:Ensembl.
DR GO; GO:0008201; F:heparin binding; IEA:Ensembl.
DR GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0061844; P:antimicrobial humoral immune response mediated by antimicrobial peptide; IBA:GO_Central.
DR GO; GO:0071222; P:cellular response to lipopolysaccharide; IBA:GO_Central.
DR GO; GO:0070098; P:chemokine-mediated signaling pathway; IBA:GO_Central.
DR GO; GO:0006954; P:inflammatory response; IBA:GO_Central.
DR GO; GO:0030593; P:neutrophil chemotaxis; IBA:GO_Central.
DR GO; GO:0051281; P:positive regulation of release of sequestered calcium ion into cytosol; IEA:Ensembl.
DR GO; GO:0042127; P:regulation of cell population proliferation; IEA:Ensembl.
DR GO; GO:0010818; P:T cell chemotaxis; IEA:Ensembl.
DR CDD; cd00273; Chemokine_CXC; 1.
DR Gene3D; 2.40.50.40; -; 1.
DR InterPro; IPR001089; Chemokine_CXC.
DR InterPro; IPR018048; Chemokine_CXC_CS.
DR InterPro; IPR001811; Chemokine_IL8-like_dom.
DR InterPro; IPR033899; CXC_Chemokine_domain.
DR InterPro; IPR036048; Interleukin_8-like_sf.
DR Pfam; PF00048; IL8; 1.
DR PRINTS; PR00437; SMALLCYTKCXC.
DR SMART; SM00199; SCY; 1.
DR SUPFAM; SSF54117; Interleukin 8-like chemokines; 1.
DR PROSITE; PS00471; SMALL_CYTOKINES_CXC; 1.
PE 2: Evidence at transcript level;
KW Chemotaxis {ECO:0000256|RuleBase:RU361149};
KW Cytokine {ECO:0000256|ARBA:ARBA00022514, ECO:0000256|RuleBase:RU361149};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW Secreted {ECO:0000256|ARBA:ARBA00022525, ECO:0000256|RuleBase:RU361149};
KW Signal {ECO:0000256|RuleBase:RU361149}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|RuleBase:RU361149"
FT CHAIN 22..94
FT /note="C-X-C motif chemokine"
FT /evidence="ECO:0000256|RuleBase:RU361149"
FT /id="PRO_5015019800"
FT DOMAIN 27..89
FT /note="Chemokine interleukin-8-like"
FT /evidence="ECO:0000259|SMART:SM00199"
SQ SEQUENCE 94 AA; 10365 MW; 9D9D8585749EA4CE CRC64;
MSVKGMAIAL AVILCATVVQ GFPMFKRGRC LCIGPGVKAV KVADIEKASI MYPSNNCDKI
EVIITLKENK GQRCLNPKSK QARLIIKKVE RKNF
//
