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Database: UniProt
Entry: H2QQV0_PANTR
LinkDB: H2QQV0_PANTR
Original site: H2QQV0_PANTR 
ID   H2QQV0_PANTR            Unreviewed;       886 AA.
AC   H2QQV0;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 2.
DT   20-JUN-2018, entry version 46.
DE   SubName: Full=Hyperpolarization activated cyclic nucleotide gated potassium channel 1 {ECO:0000313|Ensembl:ENSPTRP00000028879};
GN   Name=HCN1 {ECO:0000313|Ensembl:ENSPTRP00000028879,
GN   ECO:0000313|VGNC:VGNC:13507};
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Pan.
OX   NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000028879, ECO:0000313|Proteomes:UP000002277};
RN   [1] {ECO:0000313|Ensembl:ENSPTRP00000028879, ECO:0000313|Proteomes:UP000002277}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16136131; DOI=10.1038/nature04072;
RG   Chimpanzee sequencing and analysis consortium;
RT   "Initial sequence of the chimpanzee genome and comparison with the
RT   human genome.";
RL   Nature 437:69-87(2005).
RN   [2] {ECO:0000313|Ensembl:ENSPTRP00000028879}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
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DR   EMBL; AACZ04037903; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AACZ04037904; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AACZ04037905; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AACZ04037906; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AACZ04037907; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AACZ04037908; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_526930.5; XM_526930.6.
DR   STRING; 9598.ENSPTRP00000028879; -.
DR   PaxDb; H2QQV0; -.
DR   Ensembl; ENSPTRT00000031270; ENSPTRP00000028879; ENSPTRG00000016855.
DR   GeneID; 471552; -.
DR   KEGG; ptr:471552; -.
DR   CTD; 348980; -.
DR   VGNC; VGNC:13507; HCN1.
DR   eggNOG; KOG0498; Eukaryota.
DR   eggNOG; ENOG410XPSE; LUCA.
DR   GeneTree; ENSGT00900000140801; -.
DR   InParanoid; H2QQV0; -.
DR   KO; K04954; -.
DR   OMA; HREEDMG; -.
DR   OrthoDB; EOG091G0JQU; -.
DR   TreeFam; TF318250; -.
DR   Proteomes; UP000002277; Chromosome 5.
DR   Bgee; ENSPTRG00000016855; -.
DR   GO; GO:0030424; C:axon; IEA:Ensembl.
DR   GO; GO:0030425; C:dendrite; IEA:Ensembl.
DR   GO; GO:0098855; C:HCN channel complex; IEA:Ensembl.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0030552; F:cAMP binding; IEA:Ensembl.
DR   GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR   GO; GO:0005222; F:intracellular cAMP activated cation channel activity; IEA:Ensembl.
DR   GO; GO:0005249; F:voltage-gated potassium channel activity; IBA:GO_Central.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:Ensembl.
DR   GO; GO:0045176; P:apical protein localization; IEA:Ensembl.
DR   GO; GO:0071320; P:cellular response to cAMP; IEA:Ensembl.
DR   GO; GO:0051289; P:protein homotetramerization; IEA:Ensembl.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   GO; GO:0042391; P:regulation of membrane potential; IBA:GO_Central.
DR   GO; GO:0046549; P:retinal cone cell development; IEA:Ensembl.
DR   CDD; cd00038; CAP_ED; 1.
DR   Gene3D; 2.60.120.10; -; 1.
DR   InterPro; IPR018490; cNMP-bd-like.
DR   InterPro; IPR018488; cNMP-bd_CS.
DR   InterPro; IPR000595; cNMP-bd_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR013621; Ion_trans_N.
DR   InterPro; IPR030169; K/Na_HCN1.
DR   InterPro; IPR003938; K_chnl_volt-dep_EAG/ELK/ERG.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   PANTHER; PTHR10217:SF373; PTHR10217:SF373; 1.
DR   Pfam; PF00027; cNMP_binding; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF08412; Ion_trans_N; 1.
DR   PRINTS; PR01463; EAGCHANLFMLY.
DR   SMART; SM00100; cNMP; 1.
DR   SUPFAM; SSF51206; SSF51206; 1.
DR   PROSITE; PS00888; CNMP_BINDING_1; 1.
DR   PROSITE; PS50042; CNMP_BINDING_3; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002277};
KW   Ion channel {ECO:0000256|SAAS:SAAS00084808};
KW   Ion transport {ECO:0000256|SAAS:SAAS00502700};
KW   Membrane {ECO:0000256|SAAS:SAAS00502630, ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|SAAS:SAAS00903208};
KW   Potassium channel {ECO:0000256|SAAS:SAAS00904256};
KW   Potassium transport {ECO:0000256|SAAS:SAAS00903350};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00137614,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00137754,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|SAAS:SAAS00502637};
KW   Voltage-gated channel {ECO:0000256|SAAS:SAAS00903851}.
FT   TRANSMEM    139    163       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    368    393       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      471    577       Cyclic nucleotide-binding.
FT                                {ECO:0000259|PROSITE:PS50042}.
SQ   SEQUENCE   886 AA;  98568 MW;  C2FEC776060FE894 CRC64;
     MEGGGKPNSS SNSRDDGNSV FPAKASATGA GPAAAEKRLG TPPGGGGAGA KEHGNSVCFK
     VDGGGGGGGG EEPAGGFEDA EGPRRQYGFM QRQFTSMLQP GVNKFSLRMF GSQKAVEKEQ
     ERVKTAGFWI IHPYSDFRFY WDLIMLIMMV GNLVIIPVGI TFFTEQTTTP WIIFNVASDT
     VFLLDLIMNF RTGTVNEDSS EIILDPKVIK MNYLKSWFVV DFISSIPVDY IFLIVEKGMD
     SEVYKTARAL RIVRFTKILS LLRLLRLSRL IRYIHQWEEI FHMTYDLASA VVRIFNLIGM
     MLLLCHWDGC LQFLVPLLQD FPPDCWVSLN EMVNDSWGKQ YSYALFKAMS HMLCIGYGAQ
     APVSMSDLWI TMLSMIVGAT CYAMFVGHAT ALIQSLDSSR RQYQEKYKQV EQYMSFHKLP
     ADMRQKIHDY YEHRYQGKIF DEENILNELN DPLREEIVNF NCRKLVATMP LFANADPNFV
     TAMLSKLRFE VFQPGDYIIR EGAVGKKMYF IQHGVAGVIT KSSKEMKLTD GSYFGEICLL
     TKGRRTASVR ADTYCRLYSL SVDNFNEVLE EYPMMRRAFE TVAIDRLDRI GKKNSILLQK
     FQKDLNTGVF NNQENEILKQ IVKHDREMVQ AIAPINYPQM TTLNSTSSTT TPTSRMRTQS
     PPVYTATSLS HSNLHSPSPS TQTPQPSAIL SPCSYTTAVC SPPVQSPLAA RTFHYASPTA
     SQLSLMQQQP QQQVQQSQPP QTQPQQPSPQ PQTPGSSTPK NEVHKSTQAL HNTNLTREVR
     PLSASQPSLP HEVSTLISRP HPTVGESLAS IPQPVTAVPG TGLQAGGRST VPQRVTLFRQ
     MSSGAIPPNR GVPPAPPPPA AALPRESSSV LNTDPDAEKP RFASNL
//
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