ID H2QRB4_PANTR Unreviewed; 686 AA.
AC H2QRB4; A0A2J8KIX8;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 27-MAR-2024, entry version 72.
DE SubName: Full=Erythrocyte membrane protein band 4.1 like 4A {ECO:0000313|EMBL:JAA29085.1, ECO:0000313|Ensembl:ENSPTRP00000029321.5};
GN Name=EPB41L4A {ECO:0000313|EMBL:JAA29085.1,
GN ECO:0000313|Ensembl:ENSPTRP00000029321.5,
GN ECO:0000313|VGNC:VGNC:11939};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000029321.5, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000029321.5, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|EMBL:JAA29085.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Skeletal muscle {ECO:0000313|EMBL:JAA36492.1}, and Skin
RC {ECO:0000313|EMBL:JAA29085.1};
RA Maudhoo M.D., Meehan D.T., Norgren R.B.Jr.;
RT "De novo assembly of the reference chimpanzee transcriptome from NextGen
RT mRNA sequences.";
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSPTRP00000029321.5}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AACZ04010015; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; GABD01004015; JAA29085.1; -; mRNA.
DR EMBL; GABE01008247; JAA36492.1; -; mRNA.
DR RefSeq; XP_001143134.1; XM_001143134.4.
DR STRING; 9598.ENSPTRP00000029321; -.
DR PaxDb; 9598-ENSPTRP00000029321; -.
DR Ensembl; ENSPTRT00000031736.6; ENSPTRP00000029321.5; ENSPTRG00000017133.7.
DR GeneID; 737529; -.
DR KEGG; ptr:737529; -.
DR CTD; 64097; -.
DR VGNC; VGNC:11939; EPB41L4A.
DR eggNOG; KOG3530; Eukaryota.
DR GeneTree; ENSGT00940000159623; -.
DR HOGENOM; CLU_003623_7_0_1; -.
DR OrthoDB; 3682543at2759; -.
DR TreeFam; TF319780; -.
DR Proteomes; UP000002277; Chromosome 5.
DR Bgee; ENSPTRG00000017133; Expressed in lung and 20 other cell types or tissues.
DR GO; GO:0005856; C:cytoskeleton; IBA:GO_Central.
DR GO; GO:0008092; F:cytoskeletal protein binding; IEA:InterPro.
DR GO; GO:0031032; P:actomyosin structure organization; IBA:GO_Central.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd13186; FERM_C_NBL4_NBL5; 1.
DR CDD; cd17107; FERM_F1_EPB41L4A; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR030696; Band4.1-like4A_FERM_F1.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR000798; Ez/rad/moesin-like.
DR InterPro; IPR014847; FA.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR019747; FERM_CS.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR018979; FERM_N.
DR InterPro; IPR018980; FERM_PH-like_C.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR23280; 4.1 G PROTEIN; 1.
DR PANTHER; PTHR23280:SF4; BAND 4.1-LIKE PROTEIN 4A; 1.
DR Pfam; PF08736; FA; 1.
DR Pfam; PF09380; FERM_C; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF09379; FERM_N; 1.
DR PRINTS; PR00935; BAND41.
DR PRINTS; PR00661; ERMFAMILY.
DR SMART; SM00295; B41; 1.
DR SMART; SM01195; FA; 1.
DR SMART; SM01196; FERM_C; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS00660; FERM_1; 1.
DR PROSITE; PS00661; FERM_2; 1.
DR PROSITE; PS50057; FERM_3; 1.
PE 2: Evidence at transcript level;
KW Reference proteome {ECO:0000313|Proteomes:UP000002277}.
FT DOMAIN 11..299
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT REGION 331..551
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 574..686
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 331..383
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 397..411
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 412..433
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 453..476
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 489..506
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 517..534
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 598..618
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 654..686
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 686 AA; 79033 MW; 629676D9CB99E77C CRC64;
MGCFCAVPEE FYCEVLLLDE SKLTLTTQQQ GIKKSTKGSV VLDHVFHHVN LVEIDYFGLR
YCDRSHQTYW LDPAKTLAEH KELINTGPPY TLYFGIKFYA EDPCKLKEEI TRYQFFLQVK
QDVLQGRLPC PVNIAAQLGA YAIQSELGDY DPYKHTAGYV SEYRFVPDQK EELEEAIERI
HKTLMGQIPS EAELNYLRTA KSLEMYGVDL HPVYGENKSE YFLGLTPVGV VVYKNKKQVG
KYFWPRITKV HFKETQFELR VLGKDCNETS FFFEARSKTA CKHLWKCSVE HHTFFRMPEN
ESNSLSRKLS KFGSIRYKHR YSGRTALQMS RDLSIQLPRP DQNVTRSRSK TYPKRIAQTQ
PAESNSISRI TANMENGENE GTTKIIAPSP VKSFKKAKNE NSPDTQRSKS HAPWEENGPQ
SGLYNSPSDR TKSPKFPYTR RRNPSCGSDN DSVQPVRRRK AHNSGEDSDL KQRRRSRSRC
NTSSGSESEN SNREHRKKRN RIRQENDMVD SAPQWEAVLR RQKEKNQADP NNRRSRHRSR
SRSPDIQAKE ELWKHIQKEL VDPSGLSEEQ LKEIPYTKIE TQGDPIRIRH SHSPRSYRQY
RRSQCSDGER SVLSEVNSKT DLVPPLPVTR SSDAQGSGDA TVHQRRNGSK DSLMEEKPQT
STNNLAGKHT AKTIKTIQAS RLKTET
//
