ID H2QRF1_PANTR Unreviewed; 1211 AA.
AC H2QRF1;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=Solute carrier family 12 member 2 {ECO:0000313|Ensembl:ENSPTRP00000029417.2};
GN Name=SLC12A2 {ECO:0000313|Ensembl:ENSPTRP00000029417.2,
GN ECO:0000313|VGNC:VGNC:8637};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000029417.2, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000029417.2, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000029417.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2 chloride(out) + K(+)(out) + Na(+)(out) = 2 chloride(in) +
CC K(+)(in) + Na(+)(in); Xref=Rhea:RHEA:72395, ChEBI:CHEBI:17996,
CC ChEBI:CHEBI:29101, ChEBI:CHEBI:29103;
CC Evidence={ECO:0000256|ARBA:ARBA00034631};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:72396;
CC Evidence={ECO:0000256|ARBA:ARBA00034631};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the SLC12A transporter family.
CC {ECO:0000256|ARBA:ARBA00010593}.
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DR EMBL; AACZ04009902; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_526998.2; XM_526998.4.
DR AlphaFoldDB; H2QRF1; -.
DR PaxDb; 9598-ENSPTRP00000029417; -.
DR Ensembl; ENSPTRT00000031837.3; ENSPTRP00000029417.2; ENSPTRG00000017199.6.
DR GeneID; 471620; -.
DR CTD; 6558; -.
DR VGNC; VGNC:8637; SLC12A2.
DR eggNOG; KOG2083; Eukaryota.
DR GeneTree; ENSGT00940000155742; -.
DR HOGENOM; CLU_001883_0_0_1; -.
DR InParanoid; H2QRF1; -.
DR OrthoDB; 5490251at2759; -.
DR TreeFam; TF313191; -.
DR Proteomes; UP000002277; Chromosome 5.
DR Bgee; ENSPTRG00000017199; Expressed in skeletal muscle tissue and 21 other cell types or tissues.
DR GO; GO:0016324; C:apical plasma membrane; IBA:GO_Central.
DR GO; GO:0009925; C:basal plasma membrane; IEA:Ensembl.
DR GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:Ensembl.
DR GO; GO:0016328; C:lateral plasma membrane; IEA:Ensembl.
DR GO; GO:0043005; C:neuron projection; IEA:Ensembl.
DR GO; GO:0043025; C:neuronal cell body; IEA:Ensembl.
DR GO; GO:0008519; F:ammonium transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0051879; F:Hsp90 protein binding; IEA:Ensembl.
DR GO; GO:0019901; F:protein kinase binding; IEA:Ensembl.
DR GO; GO:0051087; F:protein-folding chaperone binding; IEA:Ensembl.
DR GO; GO:0008511; F:sodium:potassium:chloride symporter activity; IBA:GO_Central.
DR GO; GO:0006884; P:cell volume homeostasis; IBA:GO_Central.
DR GO; GO:1990869; P:cellular response to chemokine; IEA:Ensembl.
DR GO; GO:0055064; P:chloride ion homeostasis; IBA:GO_Central.
DR GO; GO:1902476; P:chloride transmembrane transport; IBA:GO_Central.
DR GO; GO:0055075; P:potassium ion homeostasis; IBA:GO_Central.
DR GO; GO:1990573; P:potassium ion import across plasma membrane; IBA:GO_Central.
DR GO; GO:0055078; P:sodium ion homeostasis; IBA:GO_Central.
DR GO; GO:0035725; P:sodium ion transmembrane transport; IBA:GO_Central.
DR GO; GO:0010818; P:T cell chemotaxis; IEA:Ensembl.
DR GO; GO:0070634; P:transepithelial ammonium transport; IEA:Ensembl.
DR GO; GO:0030321; P:transepithelial chloride transport; IEA:Ensembl.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR InterPro; IPR004841; AA-permease/SLC12A_dom.
DR InterPro; IPR013612; AA_permease_N.
DR InterPro; IPR002444; NKCC1.
DR InterPro; IPR018491; SLC12_C.
DR InterPro; IPR002443; SLC12A1/SLC12A2.
DR InterPro; IPR004842; SLC12A_fam.
DR NCBIfam; TIGR00930; 2a30; 1.
DR PANTHER; PTHR11827:SF58; SOLUTE CARRIER FAMILY 12 MEMBER 2; 1.
DR PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR Pfam; PF00324; AA_permease; 1.
DR Pfam; PF08403; AA_permease_N; 1.
DR Pfam; PF03522; SLC12; 1.
DR PRINTS; PR01207; NAKCLTRNSPRT.
DR PRINTS; PR01208; NAKCLTRSPRT1.
PE 3: Inferred from homology;
KW Ion transport {ECO:0000256|ARBA:ARBA00023201};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00023201}.
FT TRANSMEM 284..305
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 317..346
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 366..387
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 408..427
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 433..456
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 486..508
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 520..544
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 654..674
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 680..698
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 710..729
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 735..750
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 201..252
FT /note="Amino acid permease N-terminal"
FT /evidence="ECO:0000259|Pfam:PF08403"
FT DOMAIN 289..791
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 800..1211
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT REGION 36..80
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 112..140
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 152..193
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 961..988
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 120..140
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 170..190
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 961..987
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1211 AA; 131479 MW; F2D56677E1694DC2 CRC64;
MEPRPTAPSS GAPGLAGVGE TPSAAALAAA RVELPGTAVP SVPEDAAPAS RDGGGVRDEG
PAAAGDGLGR PLGPTPSQSR FQVDLVSENA GRAAAAAAAA AAAAAAAGAG AGAKQTPADR
EASGESEPAK GSEEAKGRFR VNFVDPAASS SAEDSLSDAA GVGVDGPNVS FQNGGDTVLS
EGSSLHSGGG GSGHHQHYYY DTHTNTYYLR TFGHNTMDAV PRIDHYRHTA AQLGEKLLRP
SLAELHDELE KEPFEDGFAN GEESTPTRDA VVTYTAESKG VVKFGWIKGV LVRCMLNIWG
VMLFIRLSWI VGQAGIGLSV LVIMMATVVT TITGLSTSAI ATNGFVRGGG AYYLISRSLG
PEFGGAIGLI FAFANAVAVA MYVVGFAETV VELLKEHSIL MIDEINDIRI IGAITVVILL
GISVAGMEWE AKAQIVLLVI LLLAIGDFVI GTFIPLESKK PKGFFGYKSD IFNENFGPDF
REEETFFSVF AIFFPAATGI LAGANISGDL ADPQSAIPKG TLLAILITTL VYVGIAVSVG
SCVVRDATGN INDTIVTELT NCTSAACKLN FDFSSCESSP CSYGLMNNFQ VMSMVSGFTP
LISAGIFSAT LSSALASLVS APKIFQALCK DNIYPAFQMF AKGYGKNNEP LRGYILTFLI
ALGFILIAEL NVIAPIISNF FLASYALINF SVFHASLAKS PGWRPAFKYY NMWISLLGAI
LCCIVMFVIN WWAALLTYVI VLGLYIYVTY KKPDVNWGSS TQALTYLNAL QHSIRLSGVE
DHVKNFRPQC LVMTGAPNSR PALLHLVHDF TKNVGLMICG HVHMGPRRQA MKEMSIDQAK
YQRWLIKNKM KAFYAPVHAD DLREGAQYLM QAAGLGRMKP NTLVLGFKKD WLQADMRDVD
MYINLFHDAF DIQYGVVVIR LKEGLDISHL QGQEELLSSQ EKSPGTKDVV VSVEYSKKSD
LDTSKPLSEK PITHKVEEED GKTATQPLLK KESKGPIVPL NVADQKLLEA STQFQKKQGK
NTIDVWWLFD DGGLTLLIPY LLTTKKKWKD CKIRVFIGGK INRIDHDRRA MATLLSKFRI
DFSDIMVLGD INTKPKKENI IAFEEMIEPY RLHEDDKEQD IADKMKEDEP WQITDNELEL
YKTKTYRQIR LNELLKEHSS TANIIVMSLP VARKGAVSSA LYMAWLEALS KDLPPILLVR
GNHQSVLTFY S
//
