ID H2QSZ5_PANTR Unreviewed; 476 AA.
AC H2QSZ5; A0A2J8NZQ9;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 27-MAR-2024, entry version 81.
DE SubName: Full=Transcription factor EB {ECO:0000313|EMBL:JAA07368.1, ECO:0000313|Ensembl:ENSPTRP00000090152.1};
GN Name=TFEB {ECO:0000313|EMBL:JAA07368.1,
GN ECO:0000313|Ensembl:ENSPTRP00000090152.1, ECO:0000313|VGNC:VGNC:3748};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000031026.3, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000090152.1, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|EMBL:JAA07368.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Adipose stromal {ECO:0000313|EMBL:JAA07368.1}, Skeletal muscle
RC {ECO:0000313|EMBL:JAA35394.1}, and Skin {ECO:0000313|EMBL:JAA26648.1};
RA Maudhoo M.D., Meehan D.T., Norgren R.B.Jr.;
RT "De novo assembly of the reference chimpanzee transcriptome from NextGen
RT mRNA sequences.";
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSPTRP00000031026.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the MiT/TFE family.
CC {ECO:0000256|ARBA:ARBA00008289}.
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DR EMBL; AC163737; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; GABC01003970; JAA07368.1; -; mRNA.
DR EMBL; GABD01006452; JAA26648.1; -; mRNA.
DR EMBL; GABE01009345; JAA35394.1; -; mRNA.
DR RefSeq; XP_009449511.1; XM_009451236.2.
DR RefSeq; XP_009449512.1; XM_009451237.2.
DR RefSeq; XP_009449513.1; XM_009451238.2.
DR RefSeq; XP_016800514.1; XM_016945025.1.
DR RefSeq; XP_016800515.1; XM_016945026.1.
DR RefSeq; XP_016810942.1; XM_016955453.1.
DR RefSeq; XP_016810943.1; XM_016955454.1.
DR RefSeq; XP_016810944.1; XM_016955455.1.
DR RefSeq; XP_016810946.1; XM_016955457.1.
DR RefSeq; XP_016810947.1; XM_016955458.1.
DR Ensembl; ENSPTRT00000033576.4; ENSPTRP00000031026.3; ENSPTRG00000044465.1.
DR Ensembl; ENSPTRT00000080764.1; ENSPTRP00000090152.1; ENSPTRG00000018157.7.
DR GeneID; 107975137; -.
DR KEGG; ptr:107975137; -.
DR CTD; 7942; -.
DR VGNC; VGNC:3748; TFEB.
DR eggNOG; KOG1318; Eukaryota.
DR GeneTree; ENSGT00940000159691; -.
DR HOGENOM; CLU_031638_3_1_1; -.
DR OrthoDB; 3061893at2759; -.
DR TreeFam; TF317174; -.
DR Proteomes; UP000002277; Unplaced.
DR Bgee; ENSPTRG00000018157; Expressed in hindlimb stylopod muscle and 18 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0006959; P:humoral immune response; IEA:InterPro.
DR GO; GO:0045893; P:positive regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd18927; bHLHzip_TFEB; 1.
DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR024098; bHLHzip_TFEB.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR021802; MiT/TFE_C.
DR InterPro; IPR031867; MiT/TFE_N.
DR PANTHER; PTHR45776; MIP04163P; 1.
DR PANTHER; PTHR45776:SF5; TRANSCRIPTION FACTOR EB; 1.
DR Pfam; PF11851; DUF3371; 1.
DR Pfam; PF00010; HLH; 1.
DR Pfam; PF15951; MITF_TFEB_C_3_N; 1.
DR SMART; SM00353; HLH; 1.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR PROSITE; PS50888; BHLH; 1.
PE 2: Evidence at transcript level;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 235..288
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT REGION 1..68
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 107..142
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 349..430
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 447..476
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 22..50
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 369..389
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 452..469
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 476 AA; 52835 MW; 0870B3599DC60D82 CRC64;
MASRIGLRMQ LMREQAQQEE QRERMQQQAV MHYMQQQQQQ QQQQLGGPPT PAINTPVHFQ
SPPPVPGEVL KVQSYLENPT SYHLQQSQHQ KVREYLSETY GNKFAAHISP AQGSPKPPPA
ASPGVRAGHV LSSSAGNSAP NSPMAMLHIG SNPERELDDV IDNIMRLDDV LGYINPEMQM
PNTLPLSSSH LNVYSSDPQV TASLVGVTSS SCPADLTQKR ELTDAESRAL AKERQKKDNH
NLIERRRRFN INDRIKELGM LIPKANDLDV RWNKGTILKA SVDYIRRMQK DLQKSRELEN
HSRRLEMTNK QLWLRIQELE MQARVHGLPT ASPSGMNMAE LAQQVVKQEL PSEEGPGEAL
MLGAEVPDPE PLPALPPQAP LPLPTQPPSP FHHLDFSHSL SFGGREDEGP PGYPEPLAPG
HGSPFPSLSK KDLDLMLLDD SLLPLASDPL LSTMSPEASK ASSRRSSFSM EEGDVL
//
