ID H2QTC8_PANTR Unreviewed; 232 AA.
AC H2QTC8; A0A2J8PVH1;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 70.
DE SubName: Full=T-box transcription factor 18 {ECO:0000313|Ensembl:ENSPTRP00000031423.5};
GN Name=TBX18 {ECO:0000313|Ensembl:ENSPTRP00000031423.5,
GN ECO:0000313|VGNC:VGNC:3741};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000031423.5, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000031423.5, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000031423.5}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00201}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00201}.
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DR EMBL; AACZ04027289; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H2QTC8; -.
DR SMR; H2QTC8; -.
DR Ensembl; ENSPTRT00000034003.5; ENSPTRP00000031423.5; ENSPTRG00000018390.7.
DR VGNC; VGNC:3741; TBX18.
DR GeneTree; ENSGT00940000155566; -.
DR HOGENOM; CLU_079525_0_0_1; -.
DR Proteomes; UP000002277; Chromosome 6.
DR Bgee; ENSPTRG00000018390; Expressed in fibroblast and 11 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0045893; P:positive regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd20191; T-box_TBX15_18_22-like; 1.
DR Gene3D; 2.60.40.820; Transcription factor, T-box; 1.
DR InterPro; IPR008967; p53-like_TF_DNA-bd_sf.
DR InterPro; IPR046360; T-box_DNA-bd.
DR InterPro; IPR036960; T-box_sf.
DR InterPro; IPR001699; TF_T-box.
DR InterPro; IPR018186; TF_T-box_CS.
DR PANTHER; PTHR11267; T-BOX PROTEIN-RELATED; 1.
DR PANTHER; PTHR11267:SF20; T-BOX TRANSCRIPTION FACTOR TBX18; 1.
DR Pfam; PF00907; T-box; 1.
DR PRINTS; PR00937; TBOX.
DR SMART; SM00425; TBOX; 1.
DR SUPFAM; SSF49417; p53-like transcription factors; 1.
DR PROSITE; PS01264; TBOX_2; 1.
DR PROSITE; PS50252; TBOX_3; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00201};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00201}; Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 1..172
FT /note="T-box"
FT /evidence="ECO:0000259|PROSITE:PS50252"
SQ SEQUENCE 232 AA; 26875 MW; 07E06EC090274158 CRC64;
MIITKAGRRM FPAMRVKISG LDPHQQYYIA MDIVPVDNKR YRYVYHSSKW MVAGNADSPV
PPRVYIHPDS PASGETWMRQ VISFDKLKLT NNELDDQGHI ILHSMHKYQP RVHVIRKDCG
DDLSPIKPVP SGEGVKAFSF PETVFTTVTA YQNQQITRLK IDRNPFAKGF RDSGRNRMGL
EALVESYAFW RPSLRTLTFE DIPGIPKQEY RDLKTDYIFP ERDNLVSRET KL
//
