ID H2QTD0_PANTR Unreviewed; 937 AA.
AC H2QTD0; A0A2J8PVF9; K7BBW6;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 75.
DE SubName: Full=Sorting nexin 14 {ECO:0000313|EMBL:JAA09545.1, ECO:0000313|Ensembl:ENSPTRP00000031426.5};
GN Name=SNX14 {ECO:0000313|EMBL:JAA09545.1,
GN ECO:0000313|Ensembl:ENSPTRP00000031426.5, ECO:0000313|VGNC:VGNC:3705};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000031426.5, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000031426.5, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|EMBL:JAA09545.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Adipose stromal {ECO:0000313|EMBL:JAA09545.1}, Skeletal muscle
RC {ECO:0000313|EMBL:JAA40160.1}, Skin {ECO:0000313|EMBL:JAA27547.1}, and
RC Smooth vascular {ECO:0000313|EMBL:JAA19938.1};
RA Maudhoo M.D., Meehan D.T., Norgren R.B.Jr.;
RT "De novo assembly of the reference chimpanzee transcriptome from NextGen
RT mRNA sequences.";
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSPTRP00000031426.5}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the sorting nexin family.
CC {ECO:0000256|ARBA:ARBA00010883}.
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DR EMBL; AACZ04027289; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; GABC01001793; JAA09545.1; -; mRNA.
DR EMBL; GABF01002207; JAA19938.1; -; mRNA.
DR EMBL; GABD01005553; JAA27547.1; -; mRNA.
DR EMBL; GABE01004579; JAA40160.1; -; mRNA.
DR RefSeq; XP_009449879.1; XM_009451604.2.
DR STRING; 9598.ENSPTRP00000031426; -.
DR PaxDb; 9598-ENSPTRP00000031426; -.
DR Ensembl; ENSPTRT00000034006.5; ENSPTRP00000031426.5; ENSPTRG00000018392.5.
DR GeneID; 462865; -.
DR CTD; 57231; -.
DR VGNC; VGNC:3705; SNX14.
DR eggNOG; KOG2101; Eukaryota.
DR GeneTree; ENSGT00950000182856; -.
DR HOGENOM; CLU_014115_0_0_1; -.
DR OrthoDB; 2877434at2759; -.
DR TreeFam; TF324055; -.
DR Proteomes; UP000002277; Chromosome 6.
DR Bgee; ENSPTRG00000018392; Expressed in pituitary gland and 20 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005770; C:late endosome; IBA:GO_Central.
DR GO; GO:0005764; C:lysosome; IEA:Ensembl.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0098794; C:postsynapse; IEA:GOC.
DR GO; GO:0035091; F:phosphatidylinositol binding; IBA:GO_Central.
DR GO; GO:0080025; F:phosphatidylinositol-3,5-bisphosphate binding; IEA:Ensembl.
DR GO; GO:0097352; P:autophagosome maturation; IBA:GO_Central.
DR GO; GO:0099170; P:postsynaptic modulation of chemical synaptic transmission; IEA:Ensembl.
DR CDD; cd06877; PX_SNX14; 1.
DR CDD; cd08722; RGS_SNX14; 1.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR Gene3D; 1.10.167.10; Regulator of G-protein Signalling 4, domain 2; 1.
DR InterPro; IPR003114; Phox_assoc.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR016137; RGS.
DR InterPro; IPR036305; RGS_sf.
DR InterPro; IPR044926; RGS_subdomain_2.
DR InterPro; IPR037436; SNX14_PX.
DR InterPro; IPR037892; SNX14_RGS.
DR InterPro; IPR013937; Sorting_nexin_C.
DR PANTHER; PTHR22775; SORTING NEXIN; 1.
DR PANTHER; PTHR22775:SF44; SORTING NEXIN-14; 1.
DR Pfam; PF08628; Nexin_C; 1.
DR Pfam; PF00787; PX; 1.
DR Pfam; PF02194; PXA; 1.
DR Pfam; PF00615; RGS; 1.
DR SMART; SM00312; PX; 1.
DR SMART; SM00313; PXA; 1.
DR SMART; SM00315; RGS; 1.
DR SUPFAM; SSF64268; PX domain; 1.
DR SUPFAM; SSF48097; Regulator of G-protein signaling, RGS; 1.
DR PROSITE; PS50195; PX; 1.
DR PROSITE; PS51207; PXA; 1.
DR PROSITE; PS50132; RGS; 1.
PE 2: Evidence at transcript level;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 28..45
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 52..71
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 130..304
FT /note="PXA"
FT /evidence="ECO:0000259|PROSITE:PS51207"
FT DOMAIN 336..468
FT /note="RGS"
FT /evidence="ECO:0000259|PROSITE:PS50132"
FT DOMAIN 561..681
FT /note="PX"
FT /evidence="ECO:0000259|PROSITE:PS50195"
SQ SEQUENCE 937 AA; 109191 MW; C0AFEC1BA18FF158 CRC64;
MVPWVRTMGQ KLKQRLRLDV GREICRQYPL FCFLLLCLSA ASLLLNRYIH ILMIFWSFVA
GVVTFYCSLG PDSLLPNIFF TIKYKPKQLG LQELFPQGHS CAVCGKVKCK RHRPSLLLEN
YQPWLDLKIS SKVDASLSEV LELVLENFVY PWYRDVTDDE SFVDELRITL RFFASVLIRR
IHKVDIPSII TKKLLKAAMK HIEVIVKARQ KVKNTEFLQQ AALEEYGPEL HVALRSRRDE
LHYLRKLTEL LFPYILPPKA TDCRSLTLLI REILSGSVFL PSLDFLADPD TVNHLLIIFI
DDSPPEKATE PASPLVPFLQ KFAEPRNKKP SVLKLELKQI REQQDLLFRF MNFLKQEGAV
HVLQFCLTVE EFNDRILRPE LSNDEMLSLH EELQKIYKTY CLDESIDKIR FDPFIVEEIQ
RIAEGPYIDV VKLQTMRCLF EAYEHVLSLL ENVFTPMFCH SDEYFRQLLR GAESPTRNSK
LNRNTQKRGE SFGISRIGSK IKGVFKSTTM EGAMLPNYGV AEGEDDFIEE GIVVMEDDSP
VEAVSTPNTP RNLAAWKISI PYVDFFEDPS SERKEKKERI PVFCIDVERN DRRAVGHEPE
HWSVYRRYLE FYVLESKLTE FHGAFPDAQL PSKRIIGPKN YEFLKSKREE FQEYLQKLLQ
HPELSNSQLL ADFLSPNGGE TQFLDKILPD VNLGKIIKSV PGKLMKEKGQ HLEPFIMNFI
NSCESPKPKP SRPELTILSP TSENNKKLFN DLFKNNANRA ENTERKQNQN YFMEVMTVEG
VYDYLMYVGR VVFQVPDWLH HLLMGTRILF KNTLEMYTDY YLQCKLEQLF QEHRLVSLIT
LLRDAIFCEN TEPRSLQDKQ KGAKQTFEEM MNYIPDLLVK CIGEETKYES IRLLFDGLQQ
PVLNKQLTYV LLDIVIQELF PELNKVQKEV TSVTSWM
//
