ID H2QTX6_PANTR Unreviewed; 169 AA.
AC H2QTX6; A0A2J8Q9W8;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 24-JAN-2024, entry version 76.
DE SubName: Full=Vasoactive intestinal peptide {ECO:0000313|Ensembl:ENSPTRP00000031944.4};
GN Name=VIP {ECO:0000313|Ensembl:ENSPTRP00000031944.4,
GN ECO:0000313|VGNC:VGNC:3785};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000031944.4, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000031944.4, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000031944.4}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- FUNCTION: VIP causes vasodilation, lowers arterial blood pressure,
CC stimulates myocardial contractility, increases glycogenolysis and
CC relaxes the smooth muscle of trachea, stomach and gall bladder.
CC {ECO:0000256|ARBA:ARBA00002470}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the glucagon family.
CC {ECO:0000256|ARBA:ARBA00008369}.
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DR EMBL; AACZ04040547; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_009450528.1; XM_009452253.2.
DR AlphaFoldDB; H2QTX6; -.
DR SMR; H2QTX6; -.
DR STRING; 9598.ENSPTRP00000031944; -.
DR PaxDb; 9598-ENSPTRP00000031944; -.
DR Ensembl; ENSPTRT00000034559.4; ENSPTRP00000031944.4; ENSPTRG00000018720.5.
DR GeneID; 472164; -.
DR CTD; 7432; -.
DR VGNC; VGNC:3785; VIP.
DR eggNOG; ENOG502QVTA; Eukaryota.
DR GeneTree; ENSGT00950000183154; -.
DR HOGENOM; CLU_133877_1_0_1; -.
DR InParanoid; H2QTX6; -.
DR OMA; MEVRSKP; -.
DR OrthoDB; 4164373at2759; -.
DR TreeFam; TF332804; -.
DR Proteomes; UP000002277; Chromosome 6.
DR Bgee; ENSPTRG00000018720; Expressed in colon and 17 other cell types or tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0043005; C:neuron projection; IBA:GO_Central.
DR GO; GO:0005184; F:neuropeptide hormone activity; IBA:GO_Central.
DR GO; GO:0051428; F:peptide hormone receptor binding; IBA:GO_Central.
DR GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0048242; P:epinephrine secretion; IBA:GO_Central.
DR GO; GO:0007611; P:learning or memory; IBA:GO_Central.
DR GO; GO:0048255; P:mRNA stabilization; ISS:AgBase.
DR GO; GO:0043066; P:negative regulation of apoptotic process; IBA:GO_Central.
DR GO; GO:0043267; P:negative regulation of potassium ion transport; IBA:GO_Central.
DR GO; GO:0048662; P:negative regulation of smooth muscle cell proliferation; IBA:GO_Central.
DR GO; GO:0007200; P:phospholipase C-activating G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0001938; P:positive regulation of endothelial cell proliferation; IBA:GO_Central.
DR GO; GO:0032812; P:positive regulation of epinephrine secretion; IBA:GO_Central.
DR GO; GO:0060406; P:positive regulation of penile erection; IBA:GO_Central.
DR GO; GO:0045732; P:positive regulation of protein catabolic process; IBA:GO_Central.
DR GO; GO:0070459; P:prolactin secretion; ISS:AgBase.
DR GO; GO:0032880; P:regulation of protein localization; IBA:GO_Central.
DR Gene3D; 6.10.250.590; -; 2.
DR InterPro; IPR000532; Glucagon_GIP_secretin_VIP.
DR InterPro; IPR046963; VIP/GHRH-like.
DR PANTHER; PTHR11213; GLUCAGON-FAMILY NEUROPEPTIDE; 1.
DR PANTHER; PTHR11213:SF5; VIP PEPTIDES; 1.
DR Pfam; PF00123; Hormone_2; 2.
DR SMART; SM00070; GLUCA; 2.
DR PROSITE; PS00260; GLUCAGON; 2.
PE 3: Inferred from homology;
KW Amidation {ECO:0000256|ARBA:ARBA00022815};
KW Hormone {ECO:0000256|ARBA:ARBA00022702};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..169
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5015093072"
FT DOMAIN 81..103
FT /note="Glucagon / GIP / secretin / VIP family"
FT /evidence="ECO:0000259|PROSITE:PS00260"
FT DOMAIN 124..146
FT /note="Glucagon / GIP / secretin / VIP family"
FT /evidence="ECO:0000259|PROSITE:PS00260"
SQ SEQUENCE 169 AA; 19082 MW; F325BDFEF47132C3 CRC64;
MDTRNKAQLL VLLTLLSVLF SQTSAWPLYR APSALRLGDR IPFEGANEPD QVSLKEDIDM
LQNALAENDT PYYDVSRNAR HADGVFTSDF SKLLGQLSAK KYLESLMGKR VSNISEDPVP
VKRHSDAVFT DNYTRLRKQM AVKKYLNSIL NGKRSSEGES PDFPEELEK
//