ID H2QU63_PANTR Unreviewed; 636 AA.
AC H2QU63;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 69.
DE RecName: Full=PMS2 postmeiotic segregation increased 2 {ECO:0008006|Google:ProtNLM};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000032326.5, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000032326.5, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000032326.5}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AC193266; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC211714; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H2QU63; -.
DR PaxDb; 9598-ENSPTRP00000032326; -.
DR Ensembl; ENSPTRT00000034977.5; ENSPTRP00000032326.5; ENSPTRG00000018920.5.
DR eggNOG; KOG1978; Eukaryota.
DR GeneTree; ENSGT00940000155381; -.
DR HOGENOM; CLU_004131_0_2_1; -.
DR InParanoid; H2QU63; -.
DR TreeFam; TF300711; -.
DR Proteomes; UP000002277; Chromosome 7.
DR Bgee; ENSPTRG00000018920; Expressed in lymph node and 20 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0032389; C:MutLalpha complex; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IBA:GO_Central.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IBA:GO_Central.
DR GO; GO:0016446; P:somatic hypermutation of immunoglobulin genes; IBA:GO_Central.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.1540.20; MutL, C-terminal domain, dimerisation subdomain; 1.
DR Gene3D; 3.30.1370.100; MutL, C-terminal domain, regulatory subdomain; 1.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR038973; MutL/Mlh/Pms-like.
DR InterPro; IPR014790; MutL_C.
DR InterPro; IPR042120; MutL_C_dimsub.
DR InterPro; IPR042121; MutL_C_regsub.
DR InterPro; IPR037198; MutL_C_sf.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR PANTHER; PTHR10073:SF52; MISMATCH REPAIR ENDONUCLEASE PMS2; 1.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF08676; MutL_C; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SMART; SM00853; MutL_C; 1.
DR SUPFAM; SSF118116; DNA mismatch repair protein MutL; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 20..39
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 46..65
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 76..167
FT /note="DNA mismatch repair protein S5"
FT /evidence="ECO:0000259|SMART:SM01340"
FT DOMAIN 452..596
FT /note="MutL C-terminal dimerisation"
FT /evidence="ECO:0000259|SMART:SM00853"
FT REGION 176..328
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 176..221
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 231..245
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 280..305
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 311..328
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 636 AA; 71387 MW; BDF7697230C77E53 CRC64;
MVFFPELFLI FFHPIRTVVS AYLVPGKSFL IFLLGLHIYK GKLTLIIQLI FFFGFLIGMG
LQSLIPFVQL PPSDSMCEEY GLGCSDALHN LFYISGFISQ CARGVGRSST DRQFFFVNRC
PCDPAKVCRL VNDVYRMYNR HQYPFVVLNI SSLTLFSVHV CLGNLIKMHA ADLEKPMVEK
QDQSPSLRTG EEKRDVSISR LREAFSLRHT TENKPHSPKT PEPRRSPLGQ KRGMLSSSTS
DAISDRGVLR PQKEAASSSQ GPSDPTDRAE VEKDSGHGST SVDSEGFSIP DTGSHCSSEC
VASTPGDRGS QEHVDSQEKA PETDDCFSDV DCHSNQEDTG CKFRVLPQPT NLTSPNTKCF
KKEEILSNSD IRQKLVNTQN VSASQVDVAV KINKKVVSLA KRIKQLHHEA QQSEGEQNYR
KFRARICPGE NQAAEDELRK EISKTMFAEM EIIGQFNLGF IITKLNEDIF IVDQHATDEK
YNFEMLQQHT VLQGQRLIAP QTLNLTAVNE AVLIENLEIF RKNGFDFVID ENAPVTERAK
LISLPTSKNW TFGPQDVDEL IFMLSDSPGV MCRPSRVKQM FASRACRKSV MIGTALNTSE
MKKLITHMGE MDHPWNCPHG RPTMRHIANL GVISQN
//
