ID H2QU89_PANTR Unreviewed; 212 AA.
AC H2QU89; A0A2J8KZJ7;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 27-MAR-2024, entry version 71.
DE RecName: Full=Interleukin-6 {ECO:0000256|ARBA:ARBA00019464};
GN Name=IL6 {ECO:0000313|EMBL:JAA11133.1,
GN ECO:0000313|Ensembl:ENSPTRP00000032433.4, ECO:0000313|VGNC:VGNC:4400};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000032433.4, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000032433.4, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|EMBL:JAA11133.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Adipose stromal {ECO:0000313|EMBL:JAA11133.1}, Skin
RC {ECO:0000313|EMBL:JAA30520.1}, and Smooth vascular
RC {ECO:0000313|EMBL:JAA13187.1};
RA Maudhoo M.D., Meehan D.T., Norgren R.B.Jr.;
RT "De novo assembly of the reference chimpanzee transcriptome from NextGen
RT mRNA sequences.";
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSPTRP00000032433.4}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the IL-6 superfamily.
CC {ECO:0000256|ARBA:ARBA00007432}.
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DR EMBL; AC193002; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; GABC01000205; JAA11133.1; -; mRNA.
DR EMBL; GABF01008958; JAA13187.1; -; mRNA.
DR EMBL; GABD01002580; JAA30520.1; -; mRNA.
DR RefSeq; XP_016801023.1; XM_016945534.1.
DR RefSeq; XP_518992.2; XM_518992.6.
DR STRING; 9598.ENSPTRP00000068252; -.
DR PaxDb; 9598-ENSPTRP00000032433; -.
DR Ensembl; ENSPTRT00000035090.5; ENSPTRP00000032433.4; ENSPTRG00000018979.5.
DR Ensembl; ENSPTRT00000087227.1; ENSPTRP00000092845.1; ENSPTRG00000050502.1.
DR GeneID; 463288; -.
DR CTD; 3569; -.
DR VGNC; VGNC:4400; IL6.
DR eggNOG; ENOG502S7Q4; Eukaryota.
DR GeneTree; ENSGT00390000000878; -.
DR HOGENOM; CLU_096521_0_0_1; -.
DR OrthoDB; 5352039at2759; -.
DR TreeFam; TF335984; -.
DR Proteomes; UP000002277; Chromosome 7.
DR Bgee; ENSPTRG00000018979; Expressed in spleen and 12 other cell types or tissues.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR GO; GO:0005138; F:interleukin-6 receptor binding; IEA:InterPro.
DR GO; GO:0006953; P:acute-phase response; IEA:UniProtKB-KW.
DR GO; GO:0051240; P:positive regulation of multicellular organismal process; IEA:UniProt.
DR GO; GO:0072540; P:T-helper 17 cell lineage commitment; IEA:InterPro.
DR Gene3D; 1.20.1250.10; -; 1.
DR InterPro; IPR009079; 4_helix_cytokine-like_core.
DR InterPro; IPR003574; IL-6-like.
DR InterPro; IPR030474; IL-6/GCSF/MGF.
DR InterPro; IPR030473; IL6/GCSF/MGF_CS.
DR PANTHER; PTHR48406; INTERLEUKIN-6; 1.
DR PANTHER; PTHR48406:SF1; INTERLEUKIN-6; 1.
DR Pfam; PF00489; IL6; 1.
DR PIRSF; PIRSF001935; IL6_MGF_GCSF; 1.
DR PRINTS; PR00433; IL6GCSFMGF.
DR PRINTS; PR00434; INTERLEUKIN6.
DR SMART; SM00126; IL6; 1.
DR SUPFAM; SSF47266; 4-helical cytokines; 1.
DR PROSITE; PS00254; INTERLEUKIN_6; 1.
PE 2: Evidence at transcript level;
KW Acute phase {ECO:0000256|ARBA:ARBA00022486};
KW Cytokine {ECO:0000256|ARBA:ARBA00022514};
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR001935-1};
KW Growth factor {ECO:0000256|ARBA:ARBA00023030};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 28..212
FT /note="Interleukin-6"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5015093081"
FT DISULFID 72..78
FT /evidence="ECO:0000256|PIRSR:PIRSR001935-1"
FT DISULFID 101..111
FT /evidence="ECO:0000256|PIRSR:PIRSR001935-1"
SQ SEQUENCE 212 AA; 23670 MW; E2A57A5906C8E764 CRC64;
MNSVSTSAFG PVAFSLGLLL VLPAAFPAPV PPGEDSKDVA APHRQPLTSS ERIDKQIRYI
LDGISALRKE TCNKSNMCES SKEALAENNL NLPKMAEKDG CFQSGFNEET CLVKIITGLL
EFEVYLEYLQ NRFESSEEQA RAVQMSTKVL IQFLQKKAKN LDAITTPDPT TNASLLTKLQ
AQNQWLQDMT THLILRSFKE FLQSSLRALR QM
//
