ID H2QU94_PANTR Unreviewed; 572 AA.
AC H2QU94; K7D7A3;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=Glycoprotein (Transmembrane) nmb {ECO:0000313|EMBL:JAA41958.1};
DE SubName: Full=Glycoprotein nmb {ECO:0000313|Ensembl:ENSPTRP00000032444.5};
GN Name=GPNMB {ECO:0000313|EMBL:JAA41958.1,
GN ECO:0000313|Ensembl:ENSPTRP00000032444.5, ECO:0000313|VGNC:VGNC:7386};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000032444.5, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000032444.5, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|EMBL:JAA41958.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Skeletal muscle {ECO:0000313|EMBL:JAA41958.1};
RA Maudhoo M.D., Meehan D.T., Norgren R.B.Jr.;
RT "De novo assembly of the reference chimpanzee transcriptome from NextGen
RT mRNA sequences.";
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSPTRP00000032444.5}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the PMEL/NMB family.
CC {ECO:0000256|ARBA:ARBA00025776}.
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DR EMBL; AACZ04068691; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC193536; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; GABE01002781; JAA41958.1; -; mRNA.
DR RefSeq; XP_001157101.3; XM_001157101.4.
DR PaxDb; 9598-ENSPTRP00000032444; -.
DR Ensembl; ENSPTRT00000035101.5; ENSPTRP00000032444.5; ENSPTRG00000018984.5.
DR VGNC; VGNC:7386; GPNMB.
DR eggNOG; ENOG502QVWX; Eukaryota.
DR GeneTree; ENSGT00950000183188; -.
DR HOGENOM; CLU_017264_1_0_1; -.
DR OMA; HGWRKWN; -.
DR OrthoDB; 5359029at2759; -.
DR TreeFam; TF334865; -.
DR Proteomes; UP000002277; Chromosome 7.
DR Bgee; ENSPTRG00000018984; Expressed in fibroblast and 21 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd00146; PKD; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR045219; PKAT.
DR InterPro; IPR046846; PKAT_KLD.
DR InterPro; IPR022409; PKD/Chitinase_dom.
DR InterPro; IPR000601; PKD_dom.
DR InterPro; IPR035986; PKD_dom_sf.
DR PANTHER; PTHR11861; MELANOCYTE PROTEIN PMEL 17-RELATED; 1.
DR PANTHER; PTHR11861:SF11; TRANSMEMBRANE GLYCOPROTEIN NMB; 1.
DR Pfam; PF20433; PKAT_KLD; 1.
DR Pfam; PF18911; PKD_4; 1.
DR SMART; SM00089; PKD; 1.
DR SUPFAM; SSF49299; PKD domain; 1.
DR PROSITE; PS50093; PKD; 1.
PE 2: Evidence at transcript level;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius, ECO:0000313|EMBL:JAA41958.1};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..572
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014304781"
FT TRANSMEM 500..519
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 277..315
FT /note="PKD"
FT /evidence="ECO:0000259|PROSITE:PS50093"
FT REGION 320..360
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 320..336
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 337..352
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 572 AA; 63919 MW; B57AB413D00367F3 CRC64;
MECLYYFLGF LLLAARLPLD AAKRFHDVLG NERPSAYMRE HNQLNGWSSD ENDWNEKLYP
VWKRGDMRWK NSWKGGRVQA VLTSDSPALV GSNITFAVNL IFPRCQKEDA NGNIVYEKNC
RNEAGLSADP YVYNWTAWSE DSDGENGTGQ SHHNVFPDGK PFPYHPGWRR WNFIYVFHTL
GQYFQKLGRC SVRVSVNTAN VTLGPQLMEV TVYRRHGRAY VPIAQVKDVY VVTDQIPVFV
TMFQKNDRNS SDETFLKDLP IMFDVLIHDP SHFLNYSTIN YKWSFGDNTG LFVSTNHTVN
HTYVLNGTFS LNLTVKAAAP GPCPPPPPPP RPSKPNPSLA TTLNSYDSNT PGPAGDNPLE
LSRIPDENCQ INRYGHFQAT ITIVEGILEV NIIQMTDVLM PVPWPDSSLI DFVVTCQGSI
PTEVCTIISD PTCEITQNTV CSPVDVDDMC LLTVRRTFNG SGTYCVNLTL GDDTSLALTS
TLISVPDRDP ASPLRMANSA LISVGCLAIF VTVISLLVYK KHKEYNPIEN SPGNVVRSKG
LSVFLNRAKA VFFPGNQEKD PLLKNQEFKG VS
//
