ID H2QUK3_PANTR Unreviewed; 5057 AA.
AC H2QUK3;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 70.
DE SubName: Full=ATP binding cassette subfamily A member 13 {ECO:0000313|Ensembl:ENSPTRP00000032770.6};
GN Name=ABCA13 {ECO:0000313|Ensembl:ENSPTRP00000032770.6,
GN ECO:0000313|VGNC:VGNC:13622};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000032770.6, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000032770.6, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000032770.6}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; AACZ04034168; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC193926; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC195644; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_009441006.2; XM_009442731.2.
DR PaxDb; 9598-ENSPTRP00000032770; -.
DR Ensembl; ENSPTRT00000035445.6; ENSPTRP00000032770.6; ENSPTRG00000019178.6.
DR GeneID; 743460; -.
DR KEGG; ptr:743460; -.
DR CTD; 154664; -.
DR VGNC; VGNC:13622; ABCA13.
DR eggNOG; KOG0059; Eukaryota.
DR GeneTree; ENSGT00940000161703; -.
DR HOGENOM; CLU_000074_0_0_1; -.
DR InParanoid; H2QUK3; -.
DR OMA; PNQFQNI; -.
DR OrthoDB; 6951at2759; -.
DR TreeFam; TF105191; -.
DR Proteomes; UP000002277; Chromosome 7.
DR Bgee; ENSPTRG00000019178; Expressed in bone marrow and 1 other cell type or tissue.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0042626; F:ATPase-coupled transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0005319; F:lipid transporter activity; IBA:GO_Central.
DR GO; GO:0006869; P:lipid transport; IBA:GO_Central.
DR CDD; cd03263; ABC_subfamily_A; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR013525; ABC2_TM.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR026082; ABCA.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR19229:SF113; ATP-BINDING CASSETTE SUB-FAMILY A MEMBER 13; 1.
DR PANTHER; PTHR19229; ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA; 1.
DR Pfam; PF12698; ABC2_membrane_3; 2.
DR Pfam; PF00005; ABC_tran; 2.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW Translocase {ECO:0000256|ARBA:ARBA00022967};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 24..45
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 3570..3593
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 3614..3636
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 3648..3668
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 3680..3699
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 3705..3729
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 3750..3774
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 4226..4245
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 4456..4477
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 4498..4524
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 4536..4555
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 4567..4587
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 4652..4674
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 3841..4073
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT DOMAIN 4717..4955
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
SQ SEQUENCE 5057 AA; 575859 MW; EAE11A64F277CA6D CRC64;
MGHAGCQFKA LLWKNWLCRL RNPVLFLAEF FWPCILFVIL TVLRFQEPPR YRDICYLQPR
DLPSCGVIPF VQSLLCNTGS RCRNFSYEGS MEHHFRLSRF QTAADPKKVN NLAFLKEIQD
LAEEIHGMMD KAKNLKRLWV ERSNTPDSSY GSSFFTMDLN KTEEVILKLE SLHQQPHIWD
FLLLLPRLHT SRDHVEDGMD VAVNLLQTIL NSLISLEDLD WLPLNQTFSQ VSELVLNVTI
STLTFLQQHG VAVTEPVYHL SMQNIVWDPQ KVQYDLKSQF GFDDLHTEQI LNSSAELKEI
PTDSSLEKMV CSVLSSTSEE EAEKRGHVGG CHPKWSEAKN YLVHAVSWLR VYQQVFVQWQ
QGSLLQKTLT GMGHSLEALR NQFEEESKPW KVVEALHTAL LLLNDSLSAD GSKDNHTFPK
ILQHLWKLQS LLQNLPQWPA LKRILQLDGA LRNAIAQNLH FVHEVLICLE TSANDFKWFE
LNQLKLEKDV FFWELKQMLA KNAVCPNGRF SEKEAFLPPG NSSIWGGLQG LLCYCNSSET
SVLNKLLGSV EDADRILQEV ITWHKNMSVL IPEEYLDWKE LEMQLSEASL SCTRLFLLLG
ADPSPENNVF SSDCKHQLVS TVIFHTLEKA QFFLEQAYYW KAFIKFIRKT CEVAQYVNMQ
ESFQNRLLAF PEESPCFEEN MDWKMISDNY FQFLNNLLKS PTASISRALN FTKHLLMMEK
KLHTLEDEQV NFLLSFVEFF EKLLLPNLFD SSIVPSFHSL PSLTEDILNI SSLWTNHLKS
LKRDPSATDA QKLLEFGNEV IWKMQTLESH WIRKEPKNLL RFMELILFEI NPKLLELWVY
GISKGKRAKL ENFFTLLNFS VPENEILSTS FNFSQLFHSD WPKSPAMNID FVRLSGAIIT
SLHEFGFLEQ EQISEALNTV YAIRNVSDLF SALSEPQKQE VDEILTHIHL NDFQDKDSAL
LLQIYSSFYR YIYELLNIQS RGSSLTFLTQ ISKHILDIIK QFNFQNISKA FAFLFKTAEV
LGGISNVSYC QQLLSIFNFL ELQAQSFMST EGQELEVIHT TLTGLKQLLI IDEDFRISLF
QYMSQFFNSS VEDLLDNKCL ISDNKHISSV NYSTSEESSF VFPLAQIFSN LSANVSVFNK
FMSIHCTISW LQMWTEIWET ISQLFKFDMN VFTSLHHGFT QLLDELEDDV KVSKSCQGIF
PTHNVARLIL NLFKNVTQAS DFHNWEDFLD LRDFLVALGN ALVSVKKLNL EQVEKSLFTM
EAALHQLKTF PFNASTSREF LNSLLEVFIE FSSTSEYIVR NLDSINDFLS NNLTNYGEKF
ENIITELREA IVFLRNVSHD RDLFSCADIF QNVTEFILED GFLYVNTSQR MLRILDMLNS
TFSSENTISS LKGCIVWLDV INHLYLLSNS SFSQGHLQNI LGNFRDIENK MNSILKIVTW
VLNIKKPLCS SNGSYINCVN IYLKDVTDFL NIVLTTVFEK EKKPKFEILL ALLNDSTKQV
RMSINNLTTD FDFASQSNWR YFTELILRPI EMSDEIPNQF QNIWLRLITL GKEFQKLVKG
IYFNILENNS SSKTENLLNI FATSPKEKDV NSVGNSIYHL ASYLAFSLSH DLQNSPKIII
SPEIMKVTGL GIQLIRDVFN SLMPVVHHTS PQNAGYMQAL KKVTSAMRTL KKADIDLLVD
QLEQISVNLM DFFKNISSVG TGNLVVNLLV GLMEKFVDSS HSWNVNHLLQ LSRLFPKDVV
DAVIDVYYVL PHAVRLLQGV PGKNITEGLK DVYSFTLLHG ITISNITKED FAIVIKILLD
TIELVSDKPE IISEALACFP VVWCWNHTNS GFRQNSKIDP CNVHGLMSSS FYGKVASILD
HFHLSPQGED SPCSNESSRM EITRKVVCII HELVDWNSIL LELSEVFHVN ISLVKTVQKF
WHKILPFVPP SINQTRDSIS ELCPSGSIKQ VALQIIEKLK NVNFTKVTSG ENILDKLSSL
NKILNINEDT ETSVQNIISS NLERTVQLIS EDWSLEKSTH NLLSLFMMLQ NANLTGSSLE
ALSSFIEKSE TPYNFEELWP EFQQIMKDLT QDFRIRHLLS EMNKGIKSIN SVALQNITLQ
FAHFLEILDS PSLKTLEIIE DFLLATKNWL QEYANEDYSR MIETLFIPVT NESSTEDIAL
LAKAIATFGG SLKNISREGN FDVAFLTHLL NQEQLTNFSV VQLLFENILI NSINNLAGNS
QEAAWNLNDT DLQIMNFINL ILNHMQSETS RKRVLSLRSI VDFTEQFLKT FFSLLLKEDS
ENKISLLLKY FHKDVIAEMS FVPKDKILEI LKLDQFLTLM KQDRLMNIFS SLKETIYHLM
KSSFILDNGE FYFDTHQGLK FMQDLFNALL RETSMKNKTE NNIDFFTVVS QLFFHVNKSE
DLFKLNQDLG SALHLVRECS TEMARLLDTI LHSPNKDFYA LYPTLQEVIL ANLTDLLFFI
NNSFPLRNRA TLEITKRLVG AISRASEESR VLKPLLEMSG TLVMLLNDSA DLRDLATSMD
SIVKLLKLVK KVSGKMATVF KTHFISNTKD SVKFFDTLYS IMQQSVQNLV KEIATLKKID
HFTFEKINDL LVPFLDLAFE MIGVEPYISS NSDIFSMSPS ILSYMNQSKD FSDILEEIAE
FLTSVKINLE DVKSLAVAFN NETQTFSMDS VNLWEEILGC LVPINNITNQ MDFLYPNPIS
THSGPEDIKW EIIHEVIPFL DKILSQNSTE IGSFLKMVIG LTLEALWKNL KKDNWNVSNL
LMTFTQHPDN LLKTIETVLE ASIGIKSDYE GDLNKSLYFD TPLSQNITHH QLEKAIHNVL
SRIALWRKGL LFNNSEWITS TRTLFQPLFE IFIKATTGKN VTSEKEERTK KEIIDFPYSF
KPLFCLEKYL RGLFVLTKYW QQIPLTDQSV VEMCEVFQQT VKPSEAMEML QKVKMMVVRV
LTIIAENPSW TKDILCATLS CKQSGIRHLI LSAIRGVTLA QDHFQEIEKI WSLPNQLNCE
SLSKNLSSTL ESFKSSLENA TGQDCTSQPR LETVQQHLYM LAKSLEETWS SGNPIMTFLS
NFTVTEDVKI KDLMKNITKL TEELRSSIQI SNETIHSILE ANISHSKVLF SALTVALSGK
CDQEMLHLLL TFPKGEKSWI ATEELCNLPG SKVYSLIVLL SRNLDVRAFI YKTLMPSEAN
GLLNSLLDIV SSLSALLAKA QHVFEYLPEF LHTFKITALL ETLDFQQVSQ NVQARSSAFG
SFQFVMKMVC KDQASFLSDS NMFINLPRVK ELLEDDKEKF NIPEDSTPFC LKLYQEILQL
PNGALVWTFL KPILHGKILY TPNTPEINKV IQKANYTFYI VDKLKTLSET LLEMSSLFQR
SGSGQMFNQL QEALRNKFVR NFVENQLHID VDKLTEKLQT YGGLLDEMFN HAGAGRFRFL
GSILVNLSSC VALNRFQAVQ SVDILETKAH ELLQQNSFLA SIIFNNSLFD KNFRSESVKL
PPHVSYTIRT NVLYSVRTDV VKNPSWKFHP QNLPADGFKY NYVFAPLQDM IERAIILVQT
GQEALEPAAQ TQAAPYPCHT SDLFLNNVGF FFPLIMMLTW MVSVASMVRK LVYEQEIQIE
EYMRMMGVHP MIHFLAWFLE NMAVLTISSA TLAIVLKTSG IFAHSNTFIV FLFLLDFGMS
VVMLSYLLSA FFSQANTAAL CTSLVYMISF LPYIVLLVLH NQLSFVNQTF LCLLSTTAFG
QGVFFITFLE GQETGIQWNN MYQALEQGGM TFGWVCWMIL FDSSLYFLCG WYLSNLIPGT
FGLRKPWYFP FTASYWKSVG FLVEKRQYSL SSSLFFNENF DTKGSSLQNR EGELEGSASG
VTLVSVTKEY EGHKAVVQDL SLTFYRDQIT ALLGTNGAGK TTIISMLTGL HPPTSGTIII
NGKNLQTDLS RVRMELGVCP QQDVLLDNLT VREHLLLFAS IKAPQWTKKE LHQQVNQTLQ
DVDLIQHQHK QTRALSGGLK RKLSLGIAFM GMSRTVVLDE PTSGVDPCSR HSLWDILLKY
REGRTIIFTT HHLDEAEALS DRVAVLQHGS LRCCGPPFCL KEAYGQGLRL TLTRQPSVLE
AHDLKDMACV TSLIKIYIPQ AFLKDSSGSE LTYTIPKDTD KACLKGLFQA LDENLHQLQL
TGYGISDTTL EEVFLMLLQD SNKKSHIALG TESELQNNRP TGHLSGYCGS LARPATVQGL
QLLRAQVAAL LARRLRRTLR AGKSTLADLL LPVLFVALAM GLFMVRPLAT EYPPLRLTPG
HYQRAETYFF SSGGDDLDLT RVLLRKFRDQ DLPCADLNPR QKNSSCWRTD PFSHPEFQDS
CGCLKCPNRS ASAPYLTNHL GHTLLNLSGF NMEEYLLAPS EKPRLGGWSF GLKVPSEAGG
ANGNISKPPT LAKVWYNQKG FHSLPSYLNH LNNLILWQHL PPTVDWRQYG ITLYSHPYGG
ALLNEDKILE SIRQCGVALC IVLGFSILSA SIGSSVVRDR VIGAKRLQHI SGLGYRMYWF
TNFLYDMLFY LVSVCLCVAV IVAFQLTAFT FRENLAATAL LLSLFGYATL PWMYLMSRIF
SSSDVAFISY VSLNFIFGLC TMLITIMPRL LAIISKAKNL QNIYDVLKWV FTIFPQFCLG
QGLVELCYNQ IKYDLTHNFG IDSYVSPFEM NFLGWIFVQL ASQGTVLLLL RVLLHWDLLR
WPRGHSTLQG TVKSSKDTDV EKEEKRVFEG RTNGDILVLY NLSKHYRRFF QNIIAVQDIS
LGIPKGECFG LLGVNGAGKS TTFKMLNGEV SPTSGHAIIR TPMGDAVDLS SAGAAGVLIG
YCPQQDALDE LLTGWEHLYY YCSLRGIPRQ CIPEVAGDLI RRLHLEAHAD KPVATYSGGT
KRKLSTALAL VGKPDILLLD EPSSGMDPCS KRYLWQTIMK EVREGCAAVL TSHSMEECEA
LCTRLAIMVN GSFKCLGSPQ HIKNRFGDGY TVKVWLCKEA NQHCTVSDHL KLYFPGIQFK
GQHLNLLEYH VPKRWGCLAG LFKVIENNKT FLNIKHYSIN QTTLEQVFIN FASEQQQTLQ
STLDPSTDSH HTHHLPI
//
