ID H2QUK4_PANTR Unreviewed; 325 AA.
AC H2QUK4; A0A2J8L922;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=von Willebrand factor C domain containing 2 {ECO:0000313|Ensembl:ENSPTRP00000032775.3};
GN Name=VWC2 {ECO:0000313|Ensembl:ENSPTRP00000032775.3,
GN ECO:0000313|VGNC:VGNC:50371};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000032775.3, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000032775.3, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000032775.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AACZ04034179; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC192734; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_009441076.1; XM_009442801.2.
DR AlphaFoldDB; H2QUK4; -.
DR STRING; 9598.ENSPTRP00000032775; -.
DR PaxDb; 9598-ENSPTRP00000032775; -.
DR Ensembl; ENSPTRT00000035450.4; ENSPTRP00000032775.3; ENSPTRG00000019182.4.
DR GeneID; 472363; -.
DR CTD; 375567; -.
DR VGNC; VGNC:50371; VWC2.
DR eggNOG; ENOG502QW4Q; Eukaryota.
DR GeneTree; ENSGT00720000108792; -.
DR HOGENOM; CLU_073865_0_0_1; -.
DR InParanoid; H2QUK4; -.
DR OMA; EKCHCEA; -.
DR OrthoDB; 4168067at2759; -.
DR TreeFam; TF329913; -.
DR Proteomes; UP000002277; Chromosome 7.
DR Bgee; ENSPTRG00000019182; Expressed in heart and 8 other cell types or tissues.
DR GO; GO:0032281; C:AMPA glutamate receptor complex; IBA:GO_Central.
DR GO; GO:0005604; C:basement membrane; IEA:Ensembl.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005614; C:interstitial matrix; IEA:Ensembl.
DR GO; GO:0030514; P:negative regulation of BMP signaling pathway; IBA:GO_Central.
DR GO; GO:0010811; P:positive regulation of cell-substrate adhesion; IEA:Ensembl.
DR GO; GO:0045666; P:positive regulation of neuron differentiation; IEA:Ensembl.
DR Gene3D; 6.20.200.20; -; 1.
DR InterPro; IPR042979; VWC2/VWC2L.
DR InterPro; IPR001007; VWF_dom.
DR PANTHER; PTHR46252:SF4; BRORIN; 1.
DR PANTHER; PTHR46252; BRORIN FAMILY MEMBER; 1.
DR Pfam; PF00093; VWC; 1.
DR SMART; SM00214; VWC; 2.
DR SUPFAM; SSF57603; FnI-like domain; 1.
DR PROSITE; PS01208; VWFC_1; 1.
DR PROSITE; PS50184; VWFC_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 28..325
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5015093106"
FT DOMAIN 216..274
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT REGION 37..122
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 41..82
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 325 AA; 35268 MW; CEAFBEA797AED4F0 CRC64;
MPSSTAMAVG ALSSSLLVTC CLMVALCSPS IPLEKLAQAP EQPGQEKREH ASRDGPGRVN
ELGRPARDEG GSGRDWKSKS GRGLAGREPW SKLKQAWVSQ GGGAKAGDLQ VRPRGDTPQG
EALAAAAQDA IGPELAPTPE PPEEYVYPDY RGKGCVDESG FVYAIGEKFA PGPSACPCLC
TEEGPLCAQP ECPRLHPRCI HVDTSQCCPQ CKERKNYCEF RGKTYQTLEE FVVSPCERCR
CEANGEVLCT VSACPQTECV DPVYEPDQCC PICKNGPNCF AETAVIPAGR EVKTDECTIC
HCTYEEGTWR IERQAMCTRH ECRQM
//
