ID H2QVP2_PANTR Unreviewed; 579 AA.
AC H2QVP2;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=Vasoactive intestinal peptide receptor 2 {ECO:0000313|Ensembl:ENSPTRP00000034138.4};
GN Name=VIPR2 {ECO:0000313|Ensembl:ENSPTRP00000034138.4,
GN ECO:0000313|VGNC:VGNC:4560};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000034138.4, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000034138.4, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000034138.4}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 2 family.
CC {ECO:0000256|ARBA:ARBA00005314}.
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DR EMBL; AACZ04055810; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC197206; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_009452921.2; XM_009454646.2.
DR AlphaFoldDB; H2QVP2; -.
DR PaxDb; 9598-ENSPTRP00000034138; -.
DR Ensembl; ENSPTRT00000036938.4; ENSPTRP00000034138.4; ENSPTRG00000019929.4.
DR VGNC; VGNC:4560; VIPR2.
DR eggNOG; KOG4564; Eukaryota.
DR GeneTree; ENSGT00940000158089; -.
DR HOGENOM; CLU_002753_4_4_1; -.
DR InParanoid; H2QVP2; -.
DR OrthoDB; 4226399at2759; -.
DR TreeFam; TF315710; -.
DR Proteomes; UP000002277; Chromosome 7.
DR Bgee; ENSPTRG00000019929; Expressed in thymus and 16 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0008528; F:G protein-coupled peptide receptor activity; IBA:GO_Central.
DR GO; GO:0017046; F:peptide hormone binding; IBA:GO_Central.
DR GO; GO:0004999; F:vasoactive intestinal polypeptide receptor activity; IBA:GO_Central.
DR GO; GO:0007188; P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR CDD; cd15986; 7tmB1_VIP-R2; 1.
DR Gene3D; 4.10.1240.10; GPCR, family 2, extracellular hormone receptor domain; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR036445; GPCR_2_extracell_dom_sf.
DR InterPro; IPR001879; GPCR_2_extracellular_dom.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR017983; GPCR_2_secretin-like_CS.
DR InterPro; IPR001571; GPCR_2_VIP_rcpt.
DR InterPro; IPR002284; GPCR_2_VIP_rcpt_2.
DR InterPro; IPR047035; VIP-R2_7TM.
DR PANTHER; PTHR45620; PDF RECEPTOR-LIKE PROTEIN-RELATED; 1.
DR PANTHER; PTHR45620:SF22; VASOACTIVE INTESTINAL POLYPEPTIDE RECEPTOR 2; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF02793; HRM; 1.
DR PRINTS; PR00249; GPCRSECRETIN.
DR PRINTS; PR00491; VASOACTVEIPR.
DR PRINTS; PR01155; VIP2RECEPTOR.
DR SMART; SM00008; HormR; 1.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR SUPFAM; SSF111418; Hormone receptor domain; 1.
DR PROSITE; PS00649; G_PROTEIN_RECEP_F2_1; 1.
DR PROSITE; PS00650; G_PROTEIN_RECEP_F2_2; 1.
DR PROSITE; PS50227; G_PROTEIN_RECEP_F2_3; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..579
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014174317"
FT TRANSMEM 269..292
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 301..319
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 339..362
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 382..403
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 423..448
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 472..492
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 498..519
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 178..254
FT /note="G-protein coupled receptors family 2 profile 1"
FT /evidence="ECO:0000259|PROSITE:PS50227"
FT DOMAIN 267..520
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT REGION 54..82
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 579 AA; 63977 MW; 9A01BFBD3DAA42C9 CRC64;
MRTLLPPALL TCWLLAPVSA PATPAPRRLG PGSPLPRRAL LPPVFAFLPG AGARAGSGRG
SGVARGPELP PGEREALSSG PAGLRDSGWE AACALPRAPP SGVCWKRDRF FLDASTMSSF
GAVPGAGSCG HLRGLRVSRG DRGWRWPQMP LGPSLYLLVN SIHPECRFHL EIQEEETKCA
ELLRSQTEKH KACSGVWDNI TCWRPANVGE TVTVPCPKVF SNFYSKAGNI SKNCTSDGWS
ETFPDFVDAC GYSDPEDESK ITFYILVKAI YTLGYSVSLM SLATGSIILC LFRKLHCTRN
YIHLNLFLSF ILRAISVLVK DDVLYSSSGT LHCPDQPSSW VGCKLSLVFL QYCIMANFFW
LLVEGLYLHT LLVAMLPPRR CFLAYLLIGW GLPTICIGAW TAARLYLEDT GCWDTNDHSV
PWWVIRIPIL ISIIVNFVLF ISIIRILLQK LTSPDVGGND QSQYKRLAKS TLLLIPLFGV
HYMVFAVFPI SISSKYQILF ELCLGSFQGL VVAVLYCFLN SEVQCELKRK WRSRCPTPSA
SRDYRVCGSS SSRNGSEGAL QFHRGSRAQS FLQTETSVI
//
