ID H2QXR7_PANTR Unreviewed; 251 AA.
AC H2QXR7; A0A2J8NCQ1;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 27-MAR-2024, entry version 76.
DE SubName: Full=TNF superfamily member 15 {ECO:0000313|Ensembl:ENSPTRP00000036375.1};
DE SubName: Full=Tocopherol (Alpha) transfer protein-like {ECO:0000313|EMBL:JAA07889.1};
DE SubName: Full=Tumor necrosis factor (Ligand) superfamily, member 15 {ECO:0000313|EMBL:JAA43045.1};
DE SubName: Full=Tumor necrosis factor ligand 1B {ECO:0000313|EMBL:CTQ86094.1};
GN Name=TNFSF15 {ECO:0000313|EMBL:JAA43045.1,
GN ECO:0000313|Ensembl:ENSPTRP00000036375.1,
GN ECO:0000313|VGNC:VGNC:13980};
GN Synonyms=TNLG1B {ECO:0000313|EMBL:CTQ86094.1}, TTPAL
GN {ECO:0000313|EMBL:JAA07889.1};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000036375.1, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000036375.1, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|EMBL:JAA07889.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Adipose stromal {ECO:0000313|EMBL:JAA07889.1}, and Skeletal
RC muscle {ECO:0000313|EMBL:JAA43045.1};
RA Maudhoo M.D., Meehan D.T., Norgren R.B.Jr.;
RT "De novo assembly of the reference chimpanzee transcriptome from NextGen
RT mRNA sequences.";
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:CTQ86094.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=26646413; DOI=10.1007/s00251-015-0887-5;
RA Premzl M.;
RT "Comparative genomic analysis of eutherian tumor necrosis factor ligand
RT genes.";
RL Immunogenetics 68:125-132(2016).
RN [4] {ECO:0000313|EMBL:CTQ86094.1}
RP NUCLEOTIDE SEQUENCE.
RX DOI=10.1016/j.genrep.2019.100414;
RA Premzl M.;
RT "Eutherian third-party data gene collections.";
RL Gene Rep 16:100414-100414(2019).
RN [5] {ECO:0000313|Ensembl:ENSPTRP00000036375.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the tumor necrosis factor family.
CC {ECO:0000256|ARBA:ARBA00008670}.
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DR EMBL; AACZ04069048; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; LN874329; CTQ86094.1; -; mRNA.
DR EMBL; GABC01003449; JAA07889.1; -; mRNA.
DR EMBL; GABE01001694; JAA43045.1; -; mRNA.
DR EMBL; GABE01001693; JAA43046.1; -; mRNA.
DR RefSeq; NP_001315250.1; NM_001328321.1.
DR STRING; 9598.ENSPTRP00000036375; -.
DR PaxDb; 9598-ENSPTRP00000036375; -.
DR Ensembl; ENSPTRT00000039370.2; ENSPTRP00000036375.1; ENSPTRG00000021292.4.
DR GeneID; 473468; -.
DR KEGG; ptr:473468; -.
DR CTD; 9966; -.
DR VGNC; VGNC:13980; TNFSF15.
DR eggNOG; ENOG502S4Q1; Eukaryota.
DR GeneTree; ENSGT01060000248544; -.
DR HOGENOM; CLU_070352_3_0_1; -.
DR OMA; EACVFQT; -.
DR OrthoDB; 2909163at2759; -.
DR TreeFam; TF332169; -.
DR Proteomes; UP000002277; Chromosome 9.
DR Bgee; ENSPTRG00000021292; Expressed in cortex of kidney and 4 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0005164; F:tumor necrosis factor receptor binding; IEA:InterPro.
DR GO; GO:0007154; P:cell communication; IEA:UniProt.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR GO; GO:0023052; P:signaling; IEA:UniProt.
DR CDD; cd00184; TNF; 1.
DR Gene3D; 2.60.120.40; -; 1.
DR InterPro; IPR006053; TNF.
DR InterPro; IPR006052; TNF_dom.
DR InterPro; IPR008983; Tumour_necrosis_fac-like_dom.
DR PANTHER; PTHR11471; TUMOR NECROSIS FACTOR FAMILY MEMBER; 1.
DR PANTHER; PTHR11471:SF24; TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 15; 1.
DR Pfam; PF00229; TNF; 1.
DR PRINTS; PR01234; TNECROSISFCT.
DR SMART; SM00207; TNF; 1.
DR SUPFAM; SSF49842; TNF-like; 1.
DR PROSITE; PS50049; TNF_2; 1.
PE 2: Evidence at transcript level;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 35..56
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 97..251
FT /note="TNF family profile"
FT /evidence="ECO:0000259|PROSITE:PS50049"
SQ SEQUENCE 251 AA; 28083 MW; 61E870FB053684BA CRC64;
MAEDLGLSFG ETASVEMLPE HGSCRPKARS SSARWALTCC LVLLPFLAGL TTYLLVSQLR
AQGEACVQFQ TLKGQEFAPS HQQVYAPLRA DGDKPRAHLT VVRQTPTQHL KNQFPALHWE
HELGLAFTKN RMNYTNKFLL IPESGDYFIY SQVTFRGMTS ECSEIRQAGR PNKPDSITVV
ITKVTDSYPE PTQLLMGTKS VCEVGSNWFQ PIYLGAMFSL QEGDKLMVNV SDISLVDYTK
EDKTFFGAFL L
//
