ID H2QXV5_PANTR Unreviewed; 952 AA.
AC H2QXV5;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 74.
DE SubName: Full=Adhesion G protein-coupled receptor D2 {ECO:0000313|Ensembl:ENSPTRP00000036493.4};
GN Name=ADGRD2 {ECO:0000313|Ensembl:ENSPTRP00000036493.4,
GN ECO:0000313|VGNC:VGNC:4602};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000036493.4, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000036493.4, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000036493.4}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 2 family.
CC Adhesion G-protein coupled receptor (ADGR) subfamily.
CC {ECO:0000256|ARBA:ARBA00007343}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU01172}.
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DR EMBL; AACZ04069077; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H2QXV5; -.
DR PaxDb; 9598-ENSPTRP00000036493; -.
DR Ensembl; ENSPTRT00000039498.4; ENSPTRP00000036493.4; ENSPTRG00000021356.4.
DR VGNC; VGNC:4602; ADGRD2.
DR eggNOG; KOG4193; Eukaryota.
DR GeneTree; ENSGT00940000161534; -.
DR HOGENOM; CLU_015074_0_0_1; -.
DR InParanoid; H2QXV5; -.
DR OMA; SCEQQFG; -.
DR TreeFam; TF351999; -.
DR Proteomes; UP000002277; Chromosome 9.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR CDD; cd00037; CLECT; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR000203; GPS.
DR InterPro; IPR001759; Pentraxin-related.
DR PANTHER; PTHR12011; ADHESION G-PROTEIN COUPLED RECEPTOR; 1.
DR PANTHER; PTHR12011:SF58; ADHESION G-PROTEIN COUPLED RECEPTOR D2; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF01825; GPS; 1.
DR Pfam; PF00354; Pentaxin; 1.
DR PRINTS; PR00249; GPCRSECRETIN.
DR SMART; SM00303; GPS; 1.
DR SMART; SM00159; PTX; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS50221; GPS; 1.
DR PROSITE; PS51828; PTX_2; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 651..675
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 687..704
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 716..737
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 753..772
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 792..821
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 842..866
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 872..894
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 648..895
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT REGION 18..40
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 952 AA; 102761 MW; DF800FB80DA9F56E CRC64;
MDAPWGAGER WLHGAAVDRS GVSLGPPPTP QVNQGTLGPQ VAPVAPGEVV KTAGGVCKFS
GQRLSWWQAQ ESCEQQFGHL ALQPPDGVLA SRLRDPVWVG QREAPLRRPP QRRARTTAVL
VFGERTADRA ARLRSPLPEL AALTACTHVQ WDCASPDPAA LFSVAAPALP NALQLRAFAE
PGGVVHAALV VRGHHAPFLA AFRADGRWHH VCATWEQRGG RGALGRGGLG AGHPVPSGGI
LVLGQDQDSL GGGFSVRDAF SGNLTDFHLW ARALSPAQLH RARACAPPSE GLLFRWDPGA
LDVAPWLLPT VWVRLLLPSE ECPTWNPGPR SEGSELCLEP QPFLCCYRTE PYRRLQDAQS
WPGQDVISRV NALANDIVLL PDPLSEVHGA LSPAEASSFL GLLEHVLAME MAPLGPAALL
AVVRFLKRVV ALGAGDPELL LTGPWEQLSQ GVVSVASLVL EEQVADTWLS LREVIGGPMA
LVASVQRLAP LLSTTMTSER PRMHIQHRHA GLSGVTVIHS WFTSRVFQHT LEGPDLEPQA
PANSEEANRV QRFLSTQVGS AIISSEVWDV TGEVNMAVTF HLQHQAQSPL FPPHPPSPYT
GGAWATTGCS VAALYPDSTA CFCNHSTSFA ILLQIYEVQR GPEEELLLRT LSFVGCGVSF
CALTTTFLLF LAAGVPKSER TTVHKNLTFS LASAEGFLMI SEWAKANEVA CVAVTVAMHF
LFLVAFSWML VEGLLLWRKV VAVSMHSGPG MRLYHATGWG VPVGIVMVTL AMLPHDYVAP
GHCWLNVHTN AIWAFVGPVL FVLTADTCIL ARVVMITVSS ARRRARMLSP QPCLQQQIWT
QIWATVKPVL VLLPVLGLTW LAGILVHLSP AWAYAAVGLN SIQGLYIFLV YAACNEVRSA
LQRMAEKKVA EVLRALGVWG GAAKEHSLPF SVLPLFLPPK PSTPRHPLKA PA
//
