ID H2QYA6_PANTR Unreviewed; 218 AA.
AC H2QYA6;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 60.
DE SubName: Full=Phosphoribosyl pyrophosphate synthetase 2 {ECO:0000313|Ensembl:ENSPTRP00000037123.5};
GN Name=PRPS2 {ECO:0000313|Ensembl:ENSPTRP00000037123.5,
GN ECO:0000313|VGNC:VGNC:1199};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000037123.5, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000037123.5, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000037123.5}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the ribose-phosphate pyrophosphokinase family.
CC {ECO:0000256|ARBA:ARBA00006478}.
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DR EMBL; AACZ04014643; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H2QYA6; -.
DR Ensembl; ENSPTRT00000040177.5; ENSPTRP00000037123.5; ENSPTRG00000021665.5.
DR VGNC; VGNC:1199; PRPS2.
DR eggNOG; KOG1448; Eukaryota.
DR GeneTree; ENSGT00950000182803; -.
DR HOGENOM; CLU_033546_4_0_1; -.
DR TreeFam; TF106366; -.
DR Proteomes; UP000002277; Chromosome X.
DR Bgee; ENSPTRG00000021665; Expressed in testis and 21 other cell types or tissues.
DR GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR GO; GO:0004749; F:ribose phosphate diphosphokinase activity; IEA:InterPro.
DR GO; GO:0009165; P:nucleotide biosynthetic process; IEA:UniProtKB-KW.
DR CDD; cd06223; PRTases_typeI; 1.
DR Gene3D; 3.40.50.2020; -; 3.
DR InterPro; IPR029099; Pribosyltran_N.
DR InterPro; IPR000836; PRibTrfase_dom.
DR InterPro; IPR029057; PRTase-like.
DR InterPro; IPR005946; Rib-P_diPkinase.
DR NCBIfam; TIGR01251; ribP_PPkin; 1.
DR PANTHER; PTHR10210; RIBOSE-PHOSPHATE DIPHOSPHOKINASE FAMILY MEMBER; 1.
DR PANTHER; PTHR10210:SF110; RIBOSE-PHOSPHATE PYROPHOSPHOKINASE 2; 1.
DR Pfam; PF14572; Pribosyl_synth; 1.
DR Pfam; PF13793; Pribosyltran_N; 1.
DR SUPFAM; SSF53271; PRTase-like; 2.
PE 3: Inferred from homology;
KW Nucleotide biosynthesis {ECO:0000256|ARBA:ARBA00022727};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277}.
FT DOMAIN 1..36
FT /note="Ribose-phosphate pyrophosphokinase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF13793"
SQ SEQUENCE 218 AA; 24036 MW; 522570E6B30ABAAF CRC64;
MELLIMINAC KIASSSRVTA VIPCFPYARQ DKKDKGFFDI PVDNLYAEPA VLQWIRENIA
EWKNCIIVSP DAGGAKRVTS IADRLNVEFA LIHKERKKAN EVDRMVLVGD VKDRVAILVD
DMADTCGTIC HAADKLLSAG ATKVYAILTH GIFSGPAISR INNAAFEAVV VTNTIPQEDK
MKHCTKIQVI DISMILAEAI RRTHNGESVS YLFSHVPL
//
