ID H2QYF1_PANTR Unreviewed; 334 AA.
AC H2QYF1;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 63.
DE RecName: Full=choline-phosphate cytidylyltransferase {ECO:0000256|ARBA:ARBA00026101};
DE EC=2.7.7.15 {ECO:0000256|ARBA:ARBA00026101};
GN Name=PCYT1B {ECO:0000313|Ensembl:ENSPTRP00000037300.5,
GN ECO:0000313|VGNC:VGNC:14834};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000037300.5, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000037300.5, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000037300.5}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Catalyzes the key rate-limiting step in the CDP-choline
CC pathway for phosphatidylcholine biosynthesis.
CC {ECO:0000256|ARBA:ARBA00025501}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=CTP + H(+) + phosphocholine = CDP-choline + diphosphate;
CC Xref=Rhea:RHEA:18997, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019,
CC ChEBI:CHEBI:37563, ChEBI:CHEBI:58779, ChEBI:CHEBI:295975;
CC EC=2.7.7.15; Evidence={ECO:0000256|ARBA:ARBA00024554};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:18998;
CC Evidence={ECO:0000256|ARBA:ARBA00024554};
CC -!- PATHWAY: Phospholipid metabolism; phosphatidylcholine biosynthesis;
CC phosphatidylcholine from phosphocholine: step 1/2.
CC {ECO:0000256|ARBA:ARBA00025706}.
CC -!- SIMILARITY: Belongs to the cytidylyltransferase family.
CC {ECO:0000256|ARBA:ARBA00010101}.
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DR EMBL; AACZ04014473; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04014474; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H2QYF1; -.
DR Ensembl; ENSPTRT00000040368.5; ENSPTRP00000037300.5; ENSPTRG00000021752.6.
DR VGNC; VGNC:14834; PCYT1B.
DR eggNOG; KOG2804; Eukaryota.
DR GeneTree; ENSGT00940000156040; -.
DR HOGENOM; CLU_034585_4_2_1; -.
DR OMA; FEDFSIC; -.
DR TreeFam; TF106336; -.
DR UniPathway; UPA00753; UER00739.
DR Proteomes; UP000002277; Chromosome X.
DR Bgee; ENSPTRG00000021752; Expressed in testis and 13 other cell types or tissues.
DR GO; GO:0004105; F:choline-phosphate cytidylyltransferase activity; IEA:InterPro.
DR CDD; cd02174; CCT; 1.
DR Gene3D; 3.40.50.620; HUPs; 1.
DR InterPro; IPR041723; CCT.
DR InterPro; IPR004821; Cyt_trans-like.
DR InterPro; IPR045049; Pcy1-like.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR NCBIfam; TIGR00125; cyt_tran_rel; 1.
DR PANTHER; PTHR10739:SF20; CHOLINE-PHOSPHATE CYTIDYLYLTRANSFERASE B; 1.
DR PANTHER; PTHR10739; CYTIDYLYLTRANSFERASE; 1.
DR Pfam; PF01467; CTP_transf_like; 1.
DR SUPFAM; SSF52374; Nucleotidylyl transferase; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Lipid biosynthesis {ECO:0000256|ARBA:ARBA00022516};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Phospholipid biosynthesis {ECO:0000256|ARBA:ARBA00023209};
KW Phospholipid metabolism {ECO:0000256|ARBA:ARBA00023264};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277}.
FT DOMAIN 45..173
FT /note="Cytidyltransferase-like"
FT /evidence="ECO:0000259|Pfam:PF01467"
FT REGION 274..334
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 204..231
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 274..326
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 334 AA; 38043 MW; 756CC74FF0A10ED3 CRC64;
IGPVTLTAPA PFADETNCQC QAPHEKLTIA QARLGTPADR PVRVYADGIF DLFHSGHARA
LMQAKTLFPN SYLLVGVCSD DLTHKFKGFT VMNEAERYEA LRHCRYVDEV IRDAPWTLTP
EFLEKHKIDF VAHDDIPYSS AGSDDVYKHI KEAGMFVPTQ RTEGISTSDI ITRIVRDYDV
YARRNLQRGY TAKELNVSFI NEKRYRFQNQ VDKMKEKVKN VEERSKEFVN RVEEKSHDLI
QKWEEKSREF IGNFLELFGP DGAWKQMFQE RSSRMLQALS PKQSPVSSPT RSRSPSRSPS
PTFSWLPLKT SPPSSPKAAS ASISSMSEGD EDEK
//
