ID H2QYI9_PANTR Unreviewed; 506 AA.
AC H2QYI9;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=Zinc finger protein 157 {ECO:0000313|Ensembl:ENSPTRP00000037502.6};
GN Name=ZNF157 {ECO:0000313|Ensembl:ENSPTRP00000037502.6,
GN ECO:0000313|VGNC:VGNC:1177};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000037502.6, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000037502.6, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000037502.6}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000256|ARBA:ARBA00006991}.
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DR EMBL; AACZ04031925; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04031926; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04031927; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04031928; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_016798216.1; XM_016942727.1.
DR RefSeq; XP_016798217.1; XM_016942728.1.
DR AlphaFoldDB; H2QYI9; -.
DR PaxDb; 9598-ENSPTRP00000037502; -.
DR Ensembl; ENSPTRT00000040584.6; ENSPTRP00000037502.6; ENSPTRG00000021842.6.
DR VGNC; VGNC:1177; ZNF157.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000162890; -.
DR HOGENOM; CLU_002678_0_9_1; -.
DR InParanoid; H2QYI9; -.
DR OMA; VEYNGCR; -.
DR TreeFam; TF337898; -.
DR Proteomes; UP000002277; Chromosome X.
DR Bgee; ENSPTRG00000021842; Expressed in cerebellar cortex and 5 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR Gene3D; 6.10.140.140; -; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 12.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR23226; ZINC FINGER AND SCAN DOMAIN-CONTAINING; 1.
DR PANTHER; PTHR23226:SF398; ZINC FINGER PROTEIN 715; 1.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 12.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 12.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 7.
DR SUPFAM; SSF109640; KRAB domain (Kruppel-associated box); 1.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 12.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 12.
PE 3: Inferred from homology;
KW Isopeptide bond {ECO:0000256|ARBA:ARBA00022499};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00042}.
FT DOMAIN 27..98
FT /note="KRAB"
FT /evidence="ECO:0000259|PROSITE:PS50805"
FT DOMAIN 162..189
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 190..217
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 218..245
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 246..273
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 274..301
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 302..329
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 330..357
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 358..385
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 386..413
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 414..441
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 442..469
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 470..494
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
SQ SEQUENCE 506 AA; 58264 MW; A4DF4C61803C2FEA CRC64;
MPANGTSPQR FPALIPGEPG RSFEGSVSFE DVAVDFTRQE WHRLDPAQRT MHKDVMLETY
SNLASVGLCV AKPEMIFKLE RGEELWILEE ESSGHGYSGS LSLLCGNGSV GDNALRHDND
LLHHQKIQTL DQNVEYNGCR KGFHEKTGFV RRKRTPRGDK NFECHECGKA YCRKSNLVEH
LRIHTGERPY ECGECAKTFS ARSYLIAHQK THTGERPFEC NECGKSFGRK SQLILHTRTH
TGERPYECTE CGKTFSEKAT LTIHQRTHTG EKPYECSECG KTFRVKISLT QHHRTHTGEK
PYECGECGKN FRAKKSLNQH QRIHTGEKPY ECGECGKFFR MKMTLNNHQR THTGEKPYQC
NECGKSFRVH SSLGIHQRIH TGEKPYECNE CGNAFYVKAR LIEHQRMHSG EKPYECSECG
KIFSMKKSLC QHRRTHTGEK PYECNECGNA FYVKVRLIEH QRIHTGERPF ECQECGKAFC
RKAHLTEHQR THIGWSWRCT MKKASP
//
