ID H2QZU3_PANTR Unreviewed; 493 AA.
AC H2QZU3; A0A2J8Q492;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 27-MAR-2024, entry version 71.
DE SubName: Full=Dihydrouridine synthase 2 {ECO:0000313|EMBL:JAA01802.1, ECO:0000313|Ensembl:ENSPTRP00000039555.3};
GN Name=DUS2 {ECO:0000313|Ensembl:ENSPTRP00000039555.3,
GN ECO:0000313|VGNC:VGNC:5753};
GN Synonyms=DUS2L {ECO:0000313|EMBL:JAA01802.1};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000039555.3, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000039555.3, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|EMBL:JAA01802.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Adipose stromal {ECO:0000313|EMBL:JAA01802.1}, Skeletal muscle
RC {ECO:0000313|EMBL:JAA34370.1}, Skin {ECO:0000313|EMBL:JAA27299.1}, and
RC Smooth vascular {ECO:0000313|EMBL:JAA11676.1};
RA Maudhoo M.D., Meehan D.T., Norgren R.B.Jr.;
RT "De novo assembly of the reference chimpanzee transcriptome from NextGen
RT mRNA sequences.";
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSPTRP00000039555.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=FMN; Xref=ChEBI:CHEBI:58210;
CC Evidence={ECO:0000256|ARBA:ARBA00001917};
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DR EMBL; AACZ04051790; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; GABC01009536; JAA01802.1; -; mRNA.
DR EMBL; GABF01010469; JAA11676.1; -; mRNA.
DR EMBL; GABD01005801; JAA27299.1; -; mRNA.
DR EMBL; GABE01010369; JAA34370.1; -; mRNA.
DR RefSeq; XP_009429256.1; XM_009430981.2.
DR RefSeq; XP_016784080.1; XM_016928591.1.
DR STRING; 9598.ENSPTRP00000039555; -.
DR PaxDb; 9598-ENSPTRP00000039555; -.
DR Ensembl; ENSPTRT00000049055.4; ENSPTRP00000039555.3; ENSPTRG00000008259.5.
DR GeneID; 743213; -.
DR CTD; 54920; -.
DR VGNC; VGNC:5753; DUS2.
DR eggNOG; KOG2334; Eukaryota.
DR GeneTree; ENSGT00550000075019; -.
DR HOGENOM; CLU_013299_3_0_1; -.
DR TreeFam; TF106151; -.
DR Proteomes; UP000002277; Chromosome 16.
DR Bgee; ENSPTRG00000008259; Expressed in lymph node and 20 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0003725; F:double-stranded RNA binding; IEA:Ensembl.
DR GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR GO; GO:0010181; F:FMN binding; IEA:Ensembl.
DR GO; GO:0070402; F:NADPH binding; IEA:Ensembl.
DR GO; GO:0004860; F:protein kinase inhibitor activity; IEA:Ensembl.
DR GO; GO:0000049; F:tRNA binding; IEA:InterPro.
DR GO; GO:0017150; F:tRNA dihydrouridine synthase activity; IBA:GO_Central.
DR GO; GO:0140374; P:antiviral innate immune response; IEA:Ensembl.
DR GO; GO:0002943; P:tRNA dihydrouridine synthesis; IBA:GO_Central.
DR CDD; cd19871; DSRM_DUS2L; 1.
DR CDD; cd02801; DUS_like_FMN; 1.
DR Gene3D; 3.30.160.20; -; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR014720; dsRBD_dom.
DR InterPro; IPR035587; DUS-like_FMN-bd.
DR InterPro; IPR044463; DUS2_DSRM.
DR InterPro; IPR018517; tRNA_hU_synthase_CS.
DR PANTHER; PTHR45936; TRNA-DIHYDROURIDINE(20) SYNTHASE [NAD(P)+]-LIKE; 1.
DR PANTHER; PTHR45936:SF1; TRNA-DIHYDROURIDINE(20) SYNTHASE [NAD(P)+]-LIKE; 1.
DR Pfam; PF00035; dsrm; 1.
DR Pfam; PF01207; Dus; 1.
DR SMART; SM00358; DSRM; 1.
DR SUPFAM; SSF54768; dsRNA-binding domain-like; 1.
DR SUPFAM; SSF51395; FMN-linked oxidoreductases; 1.
DR PROSITE; PS01136; UPF0034; 1.
PE 2: Evidence at transcript level;
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW FMN {ECO:0000256|ARBA:ARBA00022643};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW tRNA processing {ECO:0000256|ARBA:ARBA00022694}.
FT DOMAIN 370..435
FT /note="DRBM"
FT /evidence="ECO:0000259|SMART:SM00358"
FT REGION 330..349
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 438..493
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 443..460
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 493 AA; 55092 MW; FDCBFEFFD1285940 CRC64;
MILNSLSLYY HNKLILAPMV RVGTLPMRLL ALDYGADIVY CEELIDLKMI QCKRVVNEVL
STVDFVAPDD RVVFRTCERE QNRVVFQMGT SDAERALAVA RLVENDVAGI DVNMGCPKQY
STKGGMGAAL LSDPDKIEKI LSTLVKGTHR PVTCKIRILP SLEDTLSLVK RIERTGIAAI
AVHGRKREER PQHPVSCEVI KAIADTLSIP VIANGGSHDH IQQYSDIEDF RQATAASSVM
VARAAMWNPS IFLKEGLRPL EEVMQKYIRY AVQYDNHYTN TKYCLCQMLR EQLESPQGRL
LHAAQSSREI CEAFGLGAFY EETTQELDAQ QARLSAKTSE ETGEPAEDTS GVIKMAVKFD
RRAYPAQITP KMCLLEWCRR EKLAQPVYET VQRPLDRLFS SIVTVAEQKY QSTLWDKSKK
LAEQAAAIVC LRSQGLPEGR LGEESPSLHK RKREAPDQDP GGPRAQELAQ PGDLCKKPFV
ALGSGEESPL EGW
//
