ID H2R019_PANTR Unreviewed; 669 AA.
AC H2R019;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 70.
DE SubName: Full=Amphiphysin {ECO:0000313|Ensembl:ENSPTRP00000039993.5};
GN Name=AMPH {ECO:0000313|Ensembl:ENSPTRP00000039993.5,
GN ECO:0000313|VGNC:VGNC:4256};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000039993.5, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000039993.5, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000039993.5}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AACZ04038745; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC187381; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC189701; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC190234; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H2R019; -.
DR PaxDb; 9598-ENSPTRP00000039993; -.
DR Ensembl; ENSPTRT00000044878.5; ENSPTRP00000039993.5; ENSPTRG00000019102.6.
DR VGNC; VGNC:4256; AMPH.
DR eggNOG; KOG3771; Eukaryota.
DR GeneTree; ENSGT00950000182882; -.
DR HOGENOM; CLU_017859_4_0_1; -.
DR InParanoid; H2R019; -.
DR OMA; EXNRIAK; -.
DR TreeFam; TF313542; -.
DR Proteomes; UP000002277; Chromosome 7.
DR Bgee; ENSPTRG00000019102; Expressed in dorsolateral prefrontal cortex and 16 other cell types or tissues.
DR GO; GO:0031256; C:leading edge membrane; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0008021; C:synaptic vesicle; IBA:GO_Central.
DR GO; GO:0005543; F:phospholipid binding; IBA:GO_Central.
DR GO; GO:0048488; P:synaptic vesicle endocytosis; IBA:GO_Central.
DR CDD; cd07611; BAR_Amphiphysin_I_II; 1.
DR CDD; cd12140; SH3_Amphiphysin_I; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR003005; Amphiphysin.
DR InterPro; IPR003017; Amphiphysin_1.
DR InterPro; IPR035470; Amphiphysin_I_SH3.
DR InterPro; IPR004148; BAR_dom.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR46514; AMPHIPHYSIN; 1.
DR PANTHER; PTHR46514:SF2; AMPHIPHYSIN; 1.
DR Pfam; PF03114; BAR; 1.
DR PRINTS; PR01251; AMPHIPHYSIN.
DR PRINTS; PR01252; AMPHIPHYSIN1.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00721; BAR; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS51021; BAR; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 24..240
FT /note="BAR"
FT /evidence="ECO:0000259|PROSITE:PS51021"
FT DOMAIN 596..669
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 244..312
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 356..381
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 460..506
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 519..591
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 152..186
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 260..276
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 287..309
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 525..539
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 669 AA; 73319 MW; C9C5C98D5C241781 CRC64;
MADIKTGIFA KNVQKRLNRA QEKVLQKLGK ADETKDEQFE EYVQNFKRQE AEGTRLQREL
RGYLAAIKGM QEASMKLTES LHEVYEPDWY GREDVKMVGE KCDVLWEDFH QKLVDGSLLT
LDTYLGQFPD IKNRIAKRSR KLVDYDSARH HLEALQSSKR KDESRISKAE EEFQKAQKVF
EEFNVDLQEE LPSLWSRRVG FYVNTFKNVS SLEAKFHKEI AVLCHKLYEV MTKLGDQHAD
KAFTIQGAPS DSGPLRIAKT PSPPEEPSPL PSPTASPNHT LAPASPAPAR PRSPSQTRKG
PPVPPLPKVT PTKELQQENI ISFFEDNFVP EISVTTPSQN EVPEVKKEET LLDLDFDPFK
PEVTPAGSAG VTHSPMSQVS GDTSLFTMQT DQSKICNLAE SEQAPPTEPK AEEPLAAVTP
AVGLDLGMDT RAEEPVEEAV IIPGADADAA VGTLVSAAEG APGEEAEAEK ATVPAGEGVS
LEEAKIGTET TEGAESAQPE AEELEVTVPQ EKVIPSVVIE PASNHEGEGE NEITIGAEPK
ETTEDAAPPG PTSETPELAT EQKPIQDPQP TPSAPAMGAA DQLASAREAS QELPPGFLYK
VETLHDFEAA NSDELTLQRG DVVLVVPSDS EADQDAGWLV GVKESDWLQY RDLATYKGLF
PENFTRRLD
//
