ID   H2R0W7_PANTR            Unreviewed;      1294 AA.
AC   H2R0W7;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 2.
DT   27-MAR-2024, entry version 55.
DE   SubName: Full=von Willebrand factor A domain containing 3B {ECO:0000313|Ensembl:ENSPTRP00000041376.4};
GN   Name=VWA3B {ECO:0000313|Ensembl:ENSPTRP00000041376.4,
GN   ECO:0000313|VGNC:VGNC:412};
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pan.
OX   NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000041376.4, ECO:0000313|Proteomes:UP000002277};
RN   [1] {ECO:0000313|Ensembl:ENSPTRP00000041376.4, ECO:0000313|Proteomes:UP000002277}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16136131; DOI=10.1038/nature04072;
RG   Chimpanzee sequencing and analysis consortium;
RT   "Initial sequence of the chimpanzee genome and comparison with the human
RT   genome.";
RL   Nature 437:69-87(2005).
RN   [2] {ECO:0000313|Ensembl:ENSPTRP00000041376.4}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   EMBL; AACZ04057340; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_515640.3; XM_515640.5.
DR   PaxDb; 9598-ENSPTRP00000041376; -.
DR   Ensembl; ENSPTRT00000049373.4; ENSPTRP00000041376.4; ENSPTRG00000012263.6.
DR   GeneID; 459430; -.
DR   CTD; 200403; -.
DR   VGNC; VGNC:412; VWA3B.
DR   eggNOG; ENOG502QV6D; Eukaryota.
DR   GeneTree; ENSGT00940000157237; -.
DR   HOGENOM; CLU_008285_0_0_1; -.
DR   InParanoid; H2R0W7; -.
DR   OMA; VIMDWWY; -.
DR   OrthoDB; 5396918at2759; -.
DR   TreeFam; TF328978; -.
DR   Proteomes; UP000002277; Chromosome 2A.
DR   Bgee; ENSPTRG00000012263; Expressed in testis and 5 other cell types or tissues.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   CDD; cd00198; vWFA; 1.
DR   Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR   InterPro; IPR032770; DUF4537.
DR   InterPro; IPR002035; VWF_A.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   PANTHER; PTHR46785; VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 3B; 1.
DR   PANTHER; PTHR46785:SF1; VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 3B; 1.
DR   Pfam; PF15057; DUF4537; 1.
DR   Pfam; PF13768; VWA_3; 2.
DR   SMART; SM00327; VWA; 1.
DR   SUPFAM; SSF53300; vWA-like; 1.
DR   PROSITE; PS50234; VWFA; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000002277}.
FT   DOMAIN          508..684
FT                   /note="VWFA"
FT                   /evidence="ECO:0000259|PROSITE:PS50234"
FT   REGION          1012..1036
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1193..1248
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1224..1240
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1294 AA;  145803 MW;  A721FE8CB22F9D5C CRC64;
     MEKSGPSSTI SEQQLQRQEG WINTKTDLAE QSLISSEKWL QLHGLKSNKL TLKQILSQIG
     FPHCEDYVAS LGRPVASRYA DGLFPQLYRA EDGRVYNLTA KSELIYQFVE HLTQAVESYK
     QRMDWLTSKS RQIFGVILEQ CVTIVLDFGG ILEGELDLCR EALTMVLQEQ VAHITKFNII
     RVSQEPVKWQ ENATPVTEQS IATAISWVEK LTVELTVSEA GRLDALLEAG RDKTIESIYY
     FVVGDVPEES KELLLQRALE IPCPVYTVSF NARGEGTIAF LKDLSAKTHS RFHAFAERTE
     CVEFPAFSTK DGDNVMTWNS RKLKGKLPPG AGVREDVFLV WQEMEEACST LAQIQRLVAE
     PPKPDVATVD CESETTSVEI ASNPEDTWDS KTWLQKYGLK AQKLSLYDVL ADCSFRHADG
     VVDIKAKPEN ESVQTSAETN KKTVHAKYCS RFVHAPWKDG SLVHVNITKE KCKWYSERIH
     TALARIRRRI KWLQDGSQSL FGRLHNDCIY ILIDTSHSMK SKLDLVKDKI IQFIQEQLKY
     QSKFNFVKFD GQAVAWREQL AEVNEDNLKQ AQSWIRHIKI GSSTNTLSAL KTAFADKETR
     AIYLLTDGRP DQPPETVIDQ VKLFQEIPIY TISFNYNDEI ANRFLKEVAA LTGGEFHFYN
     FGCKDPTPPE AVQNEDLTLL VKEMEQGHSD LEKMQDLYSE SLIMDWWYNA EKDGDSKHQK
     EICSMISTPE KCAKPHSDVD STQISSLNML KGPWGLSDQK VQKKKVLHAE STKTSLLRSQ
     MSSLRSSACS ERKDGLSNAS SRRTALSDKE MSILLAEEWL DDKLSEKVTR EGSQVYDHDS
     SDVSSENWLK TYGLVAKKLT LMDALSVAAV PHSSTYVPVL DKHVVSKVFD EVFPLAHVCN
     DTNKMTLINP QGAKLNIYKR KVEQAIQSYE KRLNKIVWRA LSQEEKEKLD ANKPIQYLEN
     KTVLNQALER LNWPISLKEL SMLESEILAG KMYIQQAMEL QEAAKKNYAN KAPGEQQKLQ
     GNPTKKTKSK RPDPLKGQKV IARCDENGFY FPGVVKKCVS RTQALVGFSY GDTKVVSTSF
     ITPVGGAMPC PLLQVGDYVF AKIVIPRGFD FYVPAIVIAL PNKHVATEKF YTVLKCNNRR
     EFCPRSALIK ISQNKYALSC SHIKSPPIPE DPEVEDVEAR NSAFLFWPLK EADTQDSREP
     RREKPRRKKR PAKQPLLQAA PSDSDGFSHG TSSHGSCQGT HPEPKTAHLH FPAAGRLGLS
     SHAIIAAPPP RAALPCTLQA THSSKGLRSV PETL
//