ID H2R163_PANTR Unreviewed; 334 AA.
AC H2R163; A0A2J8JWP2;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=Cathepsin V {ECO:0000313|Ensembl:ENSPTRP00000041836.3};
GN Name=CTSV {ECO:0000313|Ensembl:ENSPTRP00000041836.3,
GN ECO:0000313|VGNC:VGNC:4667};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000041836.3, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000041836.3, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000041836.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Lysosome {ECO:0000256|ARBA:ARBA00004371}.
CC -!- SIMILARITY: Belongs to the peptidase C1 family.
CC {ECO:0000256|ARBA:ARBA00008455}.
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DR EMBL; AC183807; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_009455239.1; XM_009456964.1.
DR RefSeq; XP_016801906.1; XM_016946417.1.
DR RefSeq; XP_016816765.1; XM_016961276.1.
DR RefSeq; XP_016816766.1; XM_016961277.1.
DR RefSeq; XP_016816767.1; XM_016961278.1.
DR RefSeq; XP_520130.2; XM_520130.3.
DR STRING; 9598.ENSPTRP00000041836; -.
DR PaxDb; 9598-ENSPTRP00000041836; -.
DR Ensembl; ENSPTRT00000047906.4; ENSPTRP00000041836.3; ENSPTRG00000002675.5.
DR Ensembl; ENSPTRT00000088927.1; ENSPTRP00000063338.1; ENSPTRG00000052785.1.
DR GeneID; 107976728; -.
DR KEGG; ptr:107976728; -.
DR CTD; 1515; -.
DR VGNC; VGNC:4667; CTSV.
DR eggNOG; KOG1543; Eukaryota.
DR GeneTree; ENSGT00940000154367; -.
DR HOGENOM; CLU_012184_1_2_1; -.
DR OMA; HGKLYNE; -.
DR OrthoDB; 5472948at2759; -.
DR TreeFam; TF313739; -.
DR Proteomes; UP000002277; Chromosome 9.
DR Bgee; ENSPTRG00000002675; Expressed in thymus and 7 other cell types or tissues.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005764; C:lysosome; IEA:UniProtKB-SubCell.
DR GO; GO:0008656; F:cysteine-type endopeptidase activator activity involved in apoptotic process; IBA:GO_Central.
DR GO; GO:0004197; F:cysteine-type endopeptidase activity; IBA:GO_Central.
DR GO; GO:0006955; P:immune response; IBA:GO_Central.
DR GO; GO:2001235; P:positive regulation of apoptotic signaling pathway; IBA:GO_Central.
DR GO; GO:0051603; P:proteolysis involved in protein catabolic process; IBA:GO_Central.
DR CDD; cd02248; Peptidase_C1A; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR025661; Pept_asp_AS.
DR InterPro; IPR000169; Pept_cys_AS.
DR InterPro; IPR025660; Pept_his_AS.
DR InterPro; IPR013128; Peptidase_C1A.
DR InterPro; IPR000668; Peptidase_C1A_C.
DR InterPro; IPR039417; Peptidase_C1A_papain-like.
DR InterPro; IPR013201; Prot_inhib_I29.
DR PANTHER; PTHR12411:SF57; CATHEPSIN L2; 1.
DR PANTHER; PTHR12411; CYSTEINE PROTEASE FAMILY C1-RELATED; 1.
DR Pfam; PF08246; Inhibitor_I29; 1.
DR Pfam; PF00112; Peptidase_C1; 1.
DR PRINTS; PR00705; PAPAIN.
DR SMART; SM00848; Inhibitor_I29; 1.
DR SMART; SM00645; Pept_C1; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR PROSITE; PS00640; THIOL_PROTEASE_ASN; 1.
DR PROSITE; PS00139; THIOL_PROTEASE_CYS; 1.
DR PROSITE; PS00639; THIOL_PROTEASE_HIS; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Lysosome {ECO:0000256|ARBA:ARBA00023228};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW Signal {ECO:0000256|SAM:SignalP};
KW Thiol protease {ECO:0000256|ARBA:ARBA00022807};
KW Zymogen {ECO:0000256|ARBA:ARBA00023145}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..334
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5015019821"
FT DOMAIN 29..88
FT /note="Cathepsin propeptide inhibitor"
FT /evidence="ECO:0000259|SMART:SM00848"
FT DOMAIN 114..333
FT /note="Peptidase C1A papain C-terminal"
FT /evidence="ECO:0000259|SMART:SM00645"
SQ SEQUENCE 334 AA; 37391 MW; A098A41AC5E612D6 CRC64;
MNLSLVLAAF CLGIASAVPK FDQNLDTKWY QWKATHRRLY GANEEGWRRA VWEKNMKMIE
LHNGEYSQGK HGFTMAMNAF GDMTNEEFRQ MMGCFRNQKF RKGKVFREPL FLDLPKSVDW
RKKGYVTPVK NQKQCGSCWA FSATGALEGQ MFRKTGKLVS LSEQNLVDCS RPQGNQGCNG
GFMARAFQYV KENGGLDSEE SYPYVAMDEI CKYRPENSVA NDTGFTVVTP GKEKALMKAV
ATVGPISVAM DAGHSSFQFY KSGIYFEPDC SSKNLDHGVL VVGYGFEGAN SNNSKYWLVK
NSWGPEWGSN GYVKIAKDKN NHCGIATAAS YPNV
//
