ID H2R175_PANTR Unreviewed; 521 AA.
AC H2R175; A0A2J8IRT7;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=Cyclin L2 {ECO:0000313|Ensembl:ENSPTRP00000041901.4};
GN Name=CCNL2 {ECO:0000313|Ensembl:ENSPTRP00000041901.4,
GN ECO:0000313|VGNC:VGNC:5003};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000041901.4, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000041901.4, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000041901.4}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000256|ARBA:ARBA00004324}.
CC Nucleus, nucleoplasm {ECO:0000256|ARBA:ARBA00004642}.
CC -!- SIMILARITY: Belongs to the cyclin family. Cyclin L subfamily.
CC {ECO:0000256|ARBA:ARBA00010589}.
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DR EMBL; AACZ04067834; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_001146359.1; XM_001146359.5.
DR AlphaFoldDB; H2R175; -.
DR STRING; 9598.ENSPTRP00000041901; -.
DR PaxDb; 9598-ENSPTRP00000041901; -.
DR Ensembl; ENSPTRT00000047170.5; ENSPTRP00000041901.4; ENSPTRG00000000028.6.
DR GeneID; 457972; -.
DR KEGG; ptr:457972; -.
DR CTD; 81669; -.
DR VGNC; VGNC:5003; CCNL2.
DR eggNOG; KOG0835; Eukaryota.
DR GeneTree; ENSGT00940000159239; -.
DR HOGENOM; CLU_022000_6_1_1; -.
DR InParanoid; H2R175; -.
DR OMA; QEICMET; -.
DR OrthoDB; 4848076at2759; -.
DR TreeFam; TF101011; -.
DR Proteomes; UP000002277; Chromosome 1.
DR Bgee; ENSPTRG00000000028; Expressed in cerebellar cortex and 20 other cell types or tissues.
DR GO; GO:0000307; C:cyclin-dependent protein kinase holoenzyme complex; IEA:Ensembl.
DR GO; GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0016538; F:cyclin-dependent protein serine/threonine kinase regulator activity; IBA:GO_Central.
DR GO; GO:0043484; P:regulation of RNA splicing; IEA:Ensembl.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd20590; CYCLIN_CCNL2_rpt1; 1.
DR CDD; cd20593; CYCLIN_CCNL2_rpt2; 1.
DR Gene3D; 1.10.472.10; Cyclin-like; 2.
DR InterPro; IPR013763; Cyclin-like_dom.
DR InterPro; IPR036915; Cyclin-like_sf.
DR InterPro; IPR043198; Cyclin/Ssn8.
DR InterPro; IPR004367; Cyclin_C-dom.
DR InterPro; IPR006671; Cyclin_N.
DR PANTHER; PTHR10026; CYCLIN; 1.
DR PANTHER; PTHR10026:SF45; CYCLIN-L2; 1.
DR Pfam; PF02984; Cyclin_C; 1.
DR Pfam; PF00134; Cyclin_N; 1.
DR PIRSF; PIRSF036580; Cyclin_L; 1.
DR SMART; SM00385; CYCLIN; 2.
DR SMART; SM01332; Cyclin_C; 1.
DR SUPFAM; SSF47954; Cyclin-like; 2.
PE 3: Inferred from homology;
KW Cyclin {ECO:0000256|ARBA:ARBA00023127, ECO:0000256|RuleBase:RU000383};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 84..186
FT /note="Cyclin-like"
FT /evidence="ECO:0000259|SMART:SM00385"
FT DOMAIN 195..318
FT /note="Cyclin C-terminal"
FT /evidence="ECO:0000259|SMART:SM01332"
FT DOMAIN 199..283
FT /note="Cyclin-like"
FT /evidence="ECO:0000259|SMART:SM00385"
FT REGION 317..521
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 406..431
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 442..459
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 469..487
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 494..512
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 521 AA; 58178 MW; 7247ADABE013373F CRC64;
MAAAAAAAAG AAGSAAPAAA AGASGSGGAP SGSQGVLIGD RLYSGVLITL ENCLLPDDKL
RFTPSMSSGL DTDTETDLRV VGCELIQAAG ILLRLPQVAM ATGQVLFQRF FYTKSFVKHS
MEHVSMACVH LASKIEEAPR RIRDVINVFH RLRQLREKKK PVPLLLDQDY VNLKNQIIKA
ERRVLKELGF CVHVKHPHKI IVMYLQVLEC ERNQHLVQTS WNYMNDSLRT DVFVRFQPES
IACACIYLAA RTLEIPLPNR PHWFLLFGAS EEEIQEICLK ILQLYARKKV DLTHLEGEVE
KRKHAIEEAK AQARGLLPGG TQVLDGTSGF SPAPKLVESP KEGKGSKPSP LSVKNTKRRL
EGAKKAKADS PVNGLPKGRE SRSRSRSREQ SYSRSPSRSA SPKRRKSDSG STSGGSKSQS
RSRSRSDSPP RQAPRSAPYK GSEIRGSRKS KDCKYPQKPH KSRSRSSSRS RSRSRERADN
PGKYKKKSHY YRDQRRERSR SYERAGRRYE RDHPGHSRHR R
//
