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Database: UniProt
Entry: H2R1N2_PANTR
LinkDB: H2R1N2_PANTR
Original site: H2R1N2_PANTR 
ID   H2R1N2_PANTR            Unreviewed;      1959 AA.
AC   H2R1N2;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 2.
DT   25-APR-2018, entry version 53.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   Name=SCN10A {ECO:0000313|Ensembl:ENSPTRP00000042609,
GN   ECO:0000313|VGNC:VGNC:12180};
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Pan.
OX   NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000042609, ECO:0000313|Proteomes:UP000002277};
RN   [1] {ECO:0000313|Ensembl:ENSPTRP00000042609, ECO:0000313|Proteomes:UP000002277}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16136131; DOI=10.1038/nature04072;
RG   Chimpanzee sequencing and analysis consortium;
RT   "Initial sequence of the chimpanzee genome and comparison with the
RT   human genome.";
RL   Nature 437:69-87(2005).
RN   [2] {ECO:0000313|Ensembl:ENSPTRP00000042609}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
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DR   EMBL; AACZ04000233; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 9598.ENSPTRP00000042609; -.
DR   PaxDb; H2R1N2; -.
DR   Ensembl; ENSPTRT00000050611; ENSPTRP00000042609; ENSPTRG00000014763.
DR   VGNC; VGNC:12180; SCN10A.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128242; -.
DR   InParanoid; H2R1N2; -.
DR   OMA; WNIFDCI; -.
DR   OrthoDB; EOG091G00FK; -.
DR   TreeFam; TF323985; -.
DR   Proteomes; UP000002277; Chromosome 3.
DR   Bgee; ENSPTRG00000014763; -.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0044325; F:ion channel binding; IEA:Ensembl.
DR   GO; GO:0005244; F:voltage-gated ion channel activity; IEA:UniProtKB-KW.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IBA:GO_Central.
DR   GO; GO:0086016; P:AV node cell action potential; IEA:Ensembl.
DR   GO; GO:0086043; P:bundle of His cell action potential; IEA:Ensembl.
DR   GO; GO:0086010; P:membrane depolarization during action potential; IBA:GO_Central.
DR   GO; GO:0019228; P:neuronal action potential; IBA:GO_Central.
DR   GO; GO:0060371; P:regulation of atrial cardiac muscle cell membrane depolarization; IEA:Ensembl.
DR   GO; GO:0055117; P:regulation of cardiac muscle contraction; IEA:Ensembl.
DR   GO; GO:0002027; P:regulation of heart rate; IEA:Ensembl.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   GO; GO:0019233; P:sensory perception of pain; IEA:InterPro.
DR   Gene3D; 1.20.120.350; -; 4.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR028809; Na_channel_a10su.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR027359; Volt_channel_dom_sf.
DR   PANTHER; PTHR10037:SF208; PTHR10037:SF208; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   PRINTS; PR00170; NACHANNEL.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002277};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000256|SAAS:SAAS00085096};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000256|SAAS:SAAS00084820};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000256|SAAS:SAAS00084701};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    131    149       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    161    180       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    192    213       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    225    246       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    252    271       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    375    403       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    660    686       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    698    720       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    787    807       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    870    893       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1156   1174       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1195   1211       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1223   1241       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1272   1298       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1397   1421       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1544   1563       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1599   1627       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1702   1725       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN      134    410       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      669    897       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      907   1150       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN     1154   1429       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1479   1735       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED      400    434       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1959 AA;  220960 MW;  7F22ABF2B990FC60 CRC64;
     MEFPIGSLET NNFRRFTPES LVEIEKQIAA KQGTKKAREK HREQKDQEEK PRPQLDLKAC
     NQLPKFYGEL PAELIGEPLE DLDPFYSTHR TFMVLNKGRT ISRFSATRAL WLFSPFNLIR
     RTAIKVSVHS YPLWFSLFIT ITILVNCVCM TRTDLPEKIE YVFTVIYTFE ALIKILARGF
     CLNEFTYLRD PWNWLDFSVI TLAYVGTAID LRGISGLRTF RVLRALKTVS VIPGLKVIVG
     ALIHSVKKLA DVTILTIFCL SVFALVGLQL FKGNLKNKCV KNDMAVNETT NYSSHRKPDI
     YINKRGTSDP LLCGNGSDSG HCPDGYICLK TSDNPDFNYT SFDSFAWAFL SLFRLMTQDS
     WERLYQQTLR ASGKIYMIFF VLVIFLGSFY LVNLILAVVT MAYEEQNQAT TDEIEAKEKK
     FQEALEMLRK EQEVLAALGI DTTSLHSHNG SPLTSKNASE RRHRIKPRVS EGSTEDNKSP
     RSDPYNQRRM SFLGLASGKR RASHGSVFHF RSPGRDISLP EGVTDDGVFP GDHESHRGSL
     LLGGGAGQQG PLPRSPLPQP SNPDSRHGED EHQLPPTSEL APGAVDVSAF DAGQKKTFLS
     AEYLDEPFRA QRAMSVVSII TSVLEELEES EQKCPPCLTS LAQKYLIWDC CPMWVKLKTI
     LFGLVTDPFA ELTITLCIVV NTIFMAMEHH GMSPTFEAML QIGNIVFTIF FTAEMVFKII
     AFDPYYYFQK KWNIFDCIIV TVSLLELGVA KKGSLSVLRS FRLLRVFKLA KSWPTLNTLI
     KIIGNSVGAL GNLTIILAII VFVFALVGKQ LLGENYRNNR KNISAPHEDW PRWHMHDFFH
     SFLIVFRILC GEWIENMWAC MEVGQKSICL ILFLTVMVLG NLVVLNLFIA LLLNSFSADN
     LTAPEDDGEV NNLQVALARI QVFGHRTKQA LCSFFSRPCP FPQPKAEPEL VVKLPLSSSK
     AENHVAANTA RGSSGGLQAP RGPRDEHSDF IANPTVWVSV PIAEGESDLD DLEDDGGEDA
     QSFQQEVIPK GQQEQLQQVE RCGDHLTPRS PGTGTSSEDL APSLGETWKD ESVPQASAEG
     VDDTSSSEGS TVDCPDPEEI LRKIPELADD LEEPDDCFTE GCIRHCPCCK VDTTKSPWDV
     GWQVRKTCYR IVEHSWFESF IIFMILLSSG SLAFEDYYLD QKPTVKALLE YTDRVFTFIF
     VFEMLLKWVA YGFKKYFTNA WCWLDFLIVN ISLISLTAKI LEYSEVAPIK ALRTLRALRP
     LRALSRFEGM RVVVDALVGA IPSIMNVLLV CLIFWLIFSI MGVNLFAGKF WRCINYTDGE
     FSLVPLSIVN NKSDCKIQNS TGSFFWVNVK VNFDNVAMGY LALLQVATFK GWMDIMYAAV
     DSREVNMQPK WEDNVYMYLY FVIFIIFGGF FTLNLFVGVI IDNFNQQKKK IRGQDIFMTE
     EQKKYYNAMK KLGSKKPQKP IPRPLNKFQG FVFDIVTRQA FDITIMVLIC LNMITMMVET
     DDQSEEKTKI LGKINQFFVA VFTGECVMKL FALRQYYFTN GWNVFDFIVV VLSIASLIFS
     AILKSLQSYF SPTLFRVIRL ARIGRILRLI RAAKGIRTLL FALMMSLPAL FNIGLLLFLV
     MFIYSIFGMS SFPHVRWEAG IDDMFNFQTF ANSMLCLFQI TTSAGWDGLL SPILNTGPPY
     CDPNLPNSNG TRGDCGSPAV GIIFFTTYII ISFLIVVNMY IAVILENFNV ATEESTEPLS
     EDDFDMFYET WEKFDPEATQ FITFSALSDF ADTLSGPLRI PKPNRNILIQ MDLPLVPGDK
     IHCLDILFAF TKNVLGESGE LDSLKANMEE KFMATNLSKS SYEPIATTLR WKQEDISATV
     IQKAYRSYVL HRSMALSNTP CVPRAEEEAA SLPDEGFVAF TANENCVLPD KSETASATSF
     PPSYESVTRG LSDRVNMRTS SSIQNEDEAT SMELIAPGP
//
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