ID H2R1S1_PANTR Unreviewed; 2148 AA.
AC H2R1S1;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 71.
DE RecName: Full=Deleted in malignant brain tumors 1 protein {ECO:0000256|ARBA:ARBA00014650};
DE AltName: Full=Hensin {ECO:0000256|ARBA:ARBA00030560};
GN Name=DMBT1 {ECO:0000313|Ensembl:ENSPTRP00000042778.5};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000042778.5, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000042778.5, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000042778.5}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the DMBT1 family.
CC {ECO:0000256|ARBA:ARBA00009931}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00059}.
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DR EMBL; AACZ04051234; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04051235; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR PaxDb; 9598-ENSPTRP00000042778; -.
DR Ensembl; ENSPTRT00000046026.5; ENSPTRP00000042778.5; ENSPTRG00000022758.5.
DR eggNOG; ENOG502QQ5W; Eukaryota.
DR GeneTree; ENSGT00950000183145; -.
DR HOGENOM; CLU_230903_0_0_1; -.
DR InParanoid; H2R1S1; -.
DR TreeFam; TF329295; -.
DR Proteomes; UP000002277; Chromosome 10.
DR Bgee; ENSPTRG00000022758; Expressed in lung and 3 other cell types or tissues.
DR GO; GO:0031012; C:extracellular matrix; IBA:GO_Central.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0030670; C:phagocytic vesicle membrane; IEA:Ensembl.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0006952; P:defense response; IBA:GO_Central.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR CDD; cd00041; CUB; 2.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 2.
DR Gene3D; 3.10.250.10; SRCR-like domain; 12.
DR Gene3D; 2.60.40.4100; Zona pellucida, ZP-C domain; 1.
DR Gene3D; 2.60.40.3210; Zona pellucida, ZP-N domain; 1.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR InterPro; IPR001190; SRCR.
DR InterPro; IPR017448; SRCR-like_dom.
DR InterPro; IPR036772; SRCR-like_dom_sf.
DR InterPro; IPR042235; ZP-C.
DR InterPro; IPR001507; ZP_dom.
DR InterPro; IPR017977; ZP_dom_CS.
DR PANTHER; PTHR19331:SF22; DELETED IN MALIGNANT BRAIN TUMORS 1 PROTEIN; 1.
DR PANTHER; PTHR19331; SCAVENGER RECEPTOR DOMAIN-CONTAINING; 1.
DR Pfam; PF00431; CUB; 2.
DR Pfam; PF00530; SRCR; 12.
DR Pfam; PF00100; Zona_pellucida; 1.
DR PRINTS; PR00258; SPERACTRCPTR.
DR SMART; SM00042; CUB; 2.
DR SMART; SM00202; SR; 12.
DR SMART; SM00241; ZP; 1.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 2.
DR SUPFAM; SSF56487; SRCR-like; 12.
DR PROSITE; PS01180; CUB; 2.
DR PROSITE; PS00420; SRCR_1; 11.
DR PROSITE; PS50287; SRCR_2; 12.
DR PROSITE; PS00682; ZP_1; 1.
DR PROSITE; PS51034; ZP_2; 1.
PE 3: Inferred from homology;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00196}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..2148
FT /note="Deleted in malignant brain tumors 1 protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5030172264"
FT DOMAIN 102..202
FT /note="SRCR"
FT /evidence="ECO:0000259|PROSITE:PS50287"
FT DOMAIN 234..334
FT /note="SRCR"
FT /evidence="ECO:0000259|PROSITE:PS50287"
FT DOMAIN 363..463
FT /note="SRCR"
FT /evidence="ECO:0000259|PROSITE:PS50287"
FT DOMAIN 494..594
FT /note="SRCR"
FT /evidence="ECO:0000259|PROSITE:PS50287"
FT DOMAIN 602..702
FT /note="SRCR"
FT /evidence="ECO:0000259|PROSITE:PS50287"
FT DOMAIN 733..833
FT /note="SRCR"
FT /evidence="ECO:0000259|PROSITE:PS50287"
FT DOMAIN 862..962
FT /note="SRCR"
FT /evidence="ECO:0000259|PROSITE:PS50287"
FT DOMAIN 993..1093
FT /note="SRCR"
FT /evidence="ECO:0000259|PROSITE:PS50287"
FT DOMAIN 1122..1222
FT /note="SRCR"
FT /evidence="ECO:0000259|PROSITE:PS50287"
FT DOMAIN 1251..1351
FT /note="SRCR"
FT /evidence="ECO:0000259|PROSITE:PS50287"
FT DOMAIN 1382..1482
FT /note="SRCR"
FT /evidence="ECO:0000259|PROSITE:PS50287"
FT DOMAIN 1508..1619
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1625..1728
FT /note="SRCR"
FT /evidence="ECO:0000259|PROSITE:PS50287"
FT DOMAIN 1750..1859
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1868..2116
FT /note="ZP"
FT /evidence="ECO:0000259|PROSITE:PS51034"
FT DISULFID 127..191
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 140..201
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 171..181
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 259..323
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 272..333
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 303..313
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 388..452
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 401..462
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 432..442
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 519..583
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 532..593
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 563..573
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 627..691
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 640..701
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 671..681
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 758..822
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 771..832
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 802..812
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 887..951
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 900..961
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 931..941
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 1018..1082
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 1031..1092
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 1062..1072
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 1147..1211
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 1160..1221
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 1191..1201
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 1276..1340
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 1289..1350
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 1320..1330
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 1407..1471
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 1420..1481
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 1451..1461
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 1653..1717
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 1666..1727
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 1697..1707
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
SQ SEQUENCE 2148 AA; 232858 MW; C173D2D5033E460C CRC64;
MGISTVILEM CLLWGQVLST GGWIPRATDY ASLIPSEVPL DTTVAEGSPF PSELTLESTV
AEGSPISLES TLESTVAEGS LIPSESTLES TVAEGSDSGL ALRLVNGDGR CQGRVEILYR
GSWGTVCDDS WDTNDANVVC RQLGCGWAMS APGNARFGQG SGPIVLDDVR CSGHESYLWS
CPHNGWLSHN CGHGEDAGVI CSAAQPQSTL RPESWPVRIS PPVPTEGSES SLALRLVNGG
DRCRGRVEVL YRGSWGTVCD DYWDTNDANV VCRQLGCGWA MSAPGNAQFG QGSGPIVLDD
VRCSGHESYL WNCPHNGWLT HNCGHSEDAG VICSASQSWP TPSPDTWPTS RASTAGSESS
LALRLVNGGD RCQGRVEVLY RGSWGTVCDD SWDTSDANVV CRQLGCGWAT SALGNARFGQ
GSGPIVLDDV RCSGYESYLW SCPHNGWLSH NCQHSEDAGV ICSAAHSWST PRPDTLPTIT
LPASTVGSES SLALRLVNGG DRCQGRVEVL YRGSWGTVCD DYWDTNDANV VCRQLGCGWA
MSAPGNARFG QGSGPIVLDD VRCSGNESYL WSCPHNGWLS HNCGHGEDAG VICSGPESSL
ALRLVNGGDR CQGRVEVLYR GSWGTVCDDS WDTNDANVVC RQLGCGWATS APGNARFGQG
SGPIVLDDVR CSGHESYLWS CPNNGWLSHN CGHHEDAGVI CSAAQSRSTP RPDTLSTITL
PPSTVGSESS LTLRLVNGSD RCQGRVEILY RGSWGTVCDD SWDTSDANVV CRQLGCGWAT
SAPGNARFGQ GSGPIVLDDV RCSGHESYLW SCPHNGWLSH NCGHHEDAGV ICSAAQCLVA
PRPDTWPTSR ASTAGSESSL ALRLVNGGDR CQGRVEVLYR GSWGTVCDDS WDTSDANVVC
RQLGCGWATS APGNARFGQG SGPIVLDDVR CSGYESYLWS CPHNGWLSHN CQHSEDAGVI
CSAAHSWSTP RPDTLPTITL PASTVGSESS LALRLVNGGD RCQGRVEVLY RGSWGTVCDD
YWDTNDANVV CRQLGCGWAM SAPGNARFGR GSGPIVLDDV RCSGHESYLW SCPHNGWLSH
NCGHSEDAGV ICSASQSRLT PSPETWPTSR ASTAGSESSL ALRLVNGGDR CQGRVEVLYR
GSWGTVCDDY WDTNDANVVC RQLGCGWATS APGNARFGQG SGPIVLDDVR CSGHESYLWS
CPHNGWLSHN CGHHEDAGVI CSVSQSRPTP SPDTWPTSRA STAGSESTLA LRLVNGGDRC
RGRVEVLYRG SWGTVCDDYW DTNDANVVCR QLGCGWATSA PGNARFGQGS GPIVLDDVRC
SGHESYLWSC PHNGWLSHNC GHHEDAGVIC SAAQSQSTPR PDTWLTTNLP APPIGSESSL
ALRLVNGGDR CRGRVEVLYR GSWGTVCDDS WDTNDANVVC RQLGCGWAMS APGNARFGQG
SGPIVLDDVR CSGNESYLWS CPHNGWLTHN CGHHEDAGVI CSVTQINSTT TDWWHPTTTT
TARPSSNCGG FLFYASGTLS SPSYPAYYPN NAKCVWEIEV NSGYRINLGF SNLKLEAHHN
CSFDYVEIFD GSLNSSLLLG KICNDTRQIF TSSYNRMTIH FRSDISFQNT GFLAWYNSFP
SDATLRLVNL NSSYGLCAGR VEIYHGGTWG TVCDDSWTIQ EAEVVCRQLG CGRAVSALGN
AYFGSGSGPI TLDDVECSGT ESTLWQCRNR GWFSHNCNHR EDAGVICSGN QLSTPAPFLN
ITRPNTDYSC GGFLSQPSGG FSSPFYPGNY PNNAKCVWDI EVQNNYRVTV IFRDVQLEGG
CNYDYIEVFD GPYRSSPLIA RVCDGARGSF TSSSNFMSIR FISDHSITRR GFRAEYYSSP
SNDSTNLLCL PNHMQASVSR SYLQSLGFSA SDLVISTWNG YYECRPQITP NLVIFTIPYS
GCGTFKQADN DTIDYSNFLT AAVSGGIIKR RTDLRIHVSC RMLQNTWVDT MYIANDTIQV
EEVQYGNFDV NISFYTSSSF LYPVTSRPYY VDLNQDLYVQ AEILHSDAVL TLFVDTCVAS
PYSNDFTSLT YDLIRSGCVR DDTYGPYSSP SLRIARFRFR AFHFLNRFPS VYLRCKMVVC
RAYDPSSRCY RGCVLRSKRD VGSYLEKVDV VLGPIQLQNP PRREEEPR
//
