ID H2R1U8_PANTR Unreviewed; 1689 AA.
AC H2R1U8;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=TSC complex subunit 2 {ECO:0000313|Ensembl:ENSPTRP00000042921.4};
GN Name=TSC2 {ECO:0000313|Ensembl:ENSPTRP00000042921.4,
GN ECO:0000313|VGNC:VGNC:48997};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000042921.4, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000042921.4, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000042921.4}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AACZ04061588; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04061589; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR PaxDb; 9598-ENSPTRP00000042921; -.
DR Ensembl; ENSPTRT00000051068.4; ENSPTRP00000042921.4; ENSPTRG00000031311.4.
DR VGNC; VGNC:48997; TSC2.
DR eggNOG; KOG3687; Eukaryota.
DR GeneTree; ENSGT00950000183139; -.
DR HOGENOM; CLU_001122_0_0_1; -.
DR InParanoid; H2R1U8; -.
DR TreeFam; TF324484; -.
DR Proteomes; UP000002277; Chromosome 16.
DR Bgee; ENSPTRG00000031311; Expressed in Brodmann (1909) area 10 and 20 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR GO; GO:0005765; C:lysosomal membrane; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
DR GO; GO:0014069; C:postsynaptic density; IEA:Ensembl.
DR GO; GO:0033596; C:TSC1-TSC2 complex; IBA:GO_Central.
DR GO; GO:0005096; F:GTPase activator activity; IBA:GO_Central.
DR GO; GO:0051879; F:Hsp90 protein binding; IEA:Ensembl.
DR GO; GO:0019902; F:phosphatase binding; IEA:Ensembl.
DR GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR GO; GO:0031267; F:small GTPase binding; IEA:Ensembl.
DR GO; GO:0043276; P:anoikis; IEA:Ensembl.
DR GO; GO:0009267; P:cellular response to starvation; IEA:Ensembl.
DR GO; GO:0046627; P:negative regulation of insulin receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0051898; P:negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; IBA:GO_Central.
DR GO; GO:0032007; P:negative regulation of TOR signaling; IBA:GO_Central.
DR GO; GO:1904262; P:negative regulation of TORC1 signaling; IEA:Ensembl.
DR GO; GO:0030178; P:negative regulation of Wnt signaling pathway; IBA:GO_Central.
DR GO; GO:0016239; P:positive regulation of macroautophagy; IEA:Ensembl.
DR GO; GO:0051726; P:regulation of cell cycle; IBA:GO_Central.
DR GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.
DR Gene3D; 3.40.50.11210; Rap/Ran-GAP; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR035974; Rap/Ran-GAP_sf.
DR InterPro; IPR000331; Rap/Ran_GAP_dom.
DR InterPro; IPR018515; Tuberin-type_domain.
DR InterPro; IPR027107; Tuberin/Ral-act_asu.
DR InterPro; IPR024584; Tuberin_N.
DR PANTHER; PTHR10063; TUBERIN; 1.
DR PANTHER; PTHR10063:SF0; TUBERIN; 1.
DR Pfam; PF11864; DUF3384; 2.
DR Pfam; PF02145; Rap_GAP; 1.
DR Pfam; PF03542; Tuberin; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF111347; Rap/Ran-GAP; 1.
DR PROSITE; PS50085; RAPGAP; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468, ECO:0000256|PROSITE-
KW ProRule:PRU00165}; Reference proteome {ECO:0000313|Proteomes:UP000002277}.
FT DOMAIN 1413..1640
FT /note="Rap-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50085"
FT REGION 560..581
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 835..869
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 988..1037
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1057..1078
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1213..1370
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1648..1673
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 988..1007
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1252..1276
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1351..1366
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1689 AA; 186849 MW; 119B23D800AF7228 CRC64;
MAKPTSKDSG LKEKFKILLG LGTPRPNPRS AEGKQTEFII TAEILRELSM ECGLNNRIRM
IGQICEVAKT KKFEEHAVEA LWKAVADLLQ PERPLEARHA VLALLKAIVQ GQGERLGVLR
ALFFKVIKDY PSNEDLHERL EVFKALTDNG RHITYLEEEL ADFVLQWMDV GLSSEFLLVL
VNLVKFNSCY LDEYIARMKP LLGAPPAVSA APDTRVVGTA GSGVLLPVPR AMACPNEVVS
YEIVLSITRL IKKYRKELQV VAWDILLNII ERLLQQLQTL DSPELRTIVH DLLTTVEELC
DQNEFHGSQE RYFELVERCA DQRPESSLLN LISYRAQSIH PAKDGWIQNL QALMERFFRS
ESRGAVRIKV LDVLSFVLLI NRQFYEEELI NSVVISQLSH IPEDKDHQVR KLATQLLVDL
AEGCHTHHFN SLLDIIEKVM ARSLSPPPEL EERDVAAYSA SLEDVKTAVL GLLVILQTKL
YTLPASHATR VYEMLVSHIQ LHYKHSYTLP IASSIRLQAF DFLLLLRADS LHRLGLPNKD
GVVRFSPYCV CDYMEPERGS EKKTSGPLSP PTGPPGPAPA GPAVRLGSVP YSLLFRVLLQ
CLKQESDWKV LKLVLGRLPE SLRYKVLIFT SPCSVDQLCS ALCSMLSGPK TLERLRGAPE
GFSRTDLHLA VVPVLTALIS YHNYLDKTKQ REMVYCLEQG LIHRCASQCV VALSICSVEM
PDIIIKALPV LVVKLTHISA TASMAVPLLE FLSTLARLPH LYRNFAAEQY ASVFAISLPY
TNPSKFNQYI VCLAHHVIAM WFIRCRLPFR KDFVPFITKG LRSNVLLSFD DTPEKDSFRA
RSTSLNERPK SLRIARPPKQ GLNNSPPVKE FKESSAAEAF RCRSISVSEH VVRSRIQTSL
TSASLGSADE NSVAQADDSL KNLHLELTET CLDMMARYVF SNFTAVPKRS PVGEFLLAGG
RTKTWLVGNK LVTVTTSVGT GTRSLLGLDS GELQSGPESS SSPGVHVRQT KEAPAKLESQ
AGQQVSRGAR DRVRSMSGGH GLRVGALDVP ASQFLGSATS PGPRTAPAVK PEKASAGTRV
PMQEKTNLAA YVPLLTQGWA EILVRRPTGN TSWLMSLENP LSPFSSDINN MPLQELSNAL
MAAERFKEHR DTALYKSLSV PAASTAKPPP LPRSNTDSAV VMEEGIPGEV PVPVAPPGLE
DVEAALGMDR RTDAYSRSSS VSSQEEKSLH AEELVGRGIP IERAVSSEGG RPSVDLSFQP
SQPLSKSSSS PELQTLQDIL GDPGDKADVG RLSPEVKARS QSGTLDGESA AWSASGEDSR
GQPEGPLPSS SPRSPSGLRP RGYTISDSAP SRRGKRVERD ALKSRATASN AEKVPGINPS
FVFLQLYHSP FFGDESNKPI LLPNESQSFE RSVQLLDQIP SYDTHKIAVL YVGEGQSNSE
LAILSNEHGS YRYTEFLTGL GRLIELKDCQ PDKVYLGGLD VCGEDGQFTY CWHDDIMQAV
FHIATLMPTK DVDKHRCDKK RHLGNDFVSI VYNDSGEDFK LGTIKGQFNF VHVIVTPLDY
ECNLVSLQCR KDMEGLVDTS VAKIVSDRNL PFVARQMALH ANMASQVHHS RSNPTDIYPS
KWIARLRHIK RLRQRICEEA AYSNPSLPLV HPPSHTKAPA QTPAEPTPGY EVGQRKRLIS
SVEDFTEFV
//
