ID H2R4B3_PANTR Unreviewed; 416 AA.
AC H2R4B3; A0A2J8LJ02;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 60.
DE RecName: Full=rhomboid protease {ECO:0000256|ARBA:ARBA00013039};
DE EC=3.4.21.105 {ECO:0000256|ARBA:ARBA00013039};
GN Name=RHBDL3 {ECO:0000313|Ensembl:ENSPTRP00000046891.5,
GN ECO:0000313|VGNC:VGNC:12659};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000046891.5, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000046891.5, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000046891.5}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Cleaves type-1 transmembrane domains using a catalytic dyad
CC composed of serine and histidine that are contributed by different
CC transmembrane domains.; EC=3.4.21.105;
CC Evidence={ECO:0000256|ARBA:ARBA00000156};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the peptidase S54 family.
CC {ECO:0000256|ARBA:ARBA00009045}.
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DR EMBL; AACZ04043914; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04043915; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H2R4B3; -.
DR STRING; 9598.ENSPTRP00000046891; -.
DR Ensembl; ENSPTRT00000046615.5; ENSPTRP00000046891.5; ENSPTRG00000008987.6.
DR VGNC; VGNC:12659; RHBDL3.
DR eggNOG; KOG0027; Eukaryota.
DR eggNOG; KOG2289; Eukaryota.
DR GeneTree; ENSGT00940000158838; -.
DR HOGENOM; CLU_048023_2_1_1; -.
DR InParanoid; H2R4B3; -.
DR TreeFam; TF313540; -.
DR Proteomes; UP000002277; Chromosome 17.
DR Bgee; ENSPTRG00000008987; Expressed in primary visual cortex and 9 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IBA:GO_Central.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 1.20.1540.10; Rhomboid-like; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR022764; Peptidase_S54_rhomboid_dom.
DR InterPro; IPR035952; Rhomboid-like_sf.
DR PANTHER; PTHR45840; RHOMBOID-RELATED PROTEIN; 1.
DR PANTHER; PTHR45840:SF5; RHOMBOID-RELATED PROTEIN 3; 1.
DR Pfam; PF13499; EF-hand_7; 1.
DR Pfam; PF01694; Rhomboid; 1.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF144091; Rhomboid-like; 1.
DR PROSITE; PS50222; EF_HAND_2; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022670};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 34..69
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT REGION 369..389
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 416 AA; 46062 MW; A8D5DE854793D2BF CRC64;
MGEHPSPGPA VAACAEAERI EELEPEAEER LPAAPEDHWK VLFDQFDPGN TGYISTGKFR
SLLESHSSKL DPHKREVLLA LADSHADGQI GYQDFVSLMS NKRSNSFRQA ILQGNRRLSS
KALLEEKGLS LSQRLIRHVA YETLPREIDR KWYYDSYTCC PPPWFMITVT LLEVAFFLYN
GVSLGQFVLQ VTHPRYLKNS LVYHPQLRAQ VWRYLTYIFM HAGIEHLGLN VVLQLLVGVP
LEMVHGATRI GLVYVAGVVA ELVRHEVPVQ AAADGCGPYL YEHGVWAGRV APLPPVGLSP
VPSPKLCGAL GWRGRGHHPG CGGPEELRAE APGPVTVVDF CGHVHRLRAV RRLLEHLCLH
PAGLEAAASP LRAGGPRSGR GGKSSTHRER LRGFFSSPAQ LGRADKDRRL WATVMF
//
