GenomeNet

Database: UniProt
Entry: H2R4D6_PANTR
LinkDB: H2R4D6_PANTR
Original site: H2R4D6_PANTR 
ID   H2R4D6_PANTR            Unreviewed;       377 AA.
AC   H2R4D6; A0A2J8M0B2;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 2.
DT   24-JAN-2024, entry version 83.
DE   SubName: Full=Diencephalon/mesencephalon homeobox 1 {ECO:0000313|Ensembl:ENSPTRP00000047003.4};
GN   Name=DMBX1 {ECO:0000313|Ensembl:ENSPTRP00000047003.4,
GN   ECO:0000313|VGNC:VGNC:8154};
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pan.
OX   NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000047003.4, ECO:0000313|Proteomes:UP000002277};
RN   [1] {ECO:0000313|Ensembl:ENSPTRP00000047003.4, ECO:0000313|Proteomes:UP000002277}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16136131; DOI=10.1038/nature04072;
RG   Chimpanzee sequencing and analysis consortium;
RT   "Initial sequence of the chimpanzee genome and comparison with the human
RT   genome.";
RL   Nature 437:69-87(2005).
RN   [2] {ECO:0000313|Ensembl:ENSPTRP00000047003.4}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC       ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
CC   -!- SIMILARITY: Belongs to the paired homeobox family.
CC       {ECO:0000256|ARBA:ARBA00005733}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AACZ04032970; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC194746; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_524575.3; XM_524575.5.
DR   AlphaFoldDB; H2R4D6; -.
DR   STRING; 9598.ENSPTRP00000047003; -.
DR   PaxDb; 9598-ENSPTRP00000047003; -.
DR   Ensembl; ENSPTRT00000049902.4; ENSPTRP00000047003.4; ENSPTRG00000024252.4.
DR   GeneID; 469190; -.
DR   CTD; 127343; -.
DR   VGNC; VGNC:8154; DMBX1.
DR   eggNOG; KOG0490; Eukaryota.
DR   GeneTree; ENSGT00940000155505; -.
DR   HOGENOM; CLU_060969_0_0_1; -.
DR   InParanoid; H2R4D6; -.
DR   OMA; NSLNAMY; -.
DR   OrthoDB; 4227585at2759; -.
DR   TreeFam; TF351609; -.
DR   Proteomes; UP000002277; Chromosome 1.
DR   Bgee; ENSPTRG00000024252; Expressed in testis.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005667; C:transcription regulator complex; IEA:Ensembl.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IEA:Ensembl.
DR   GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR   GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0008343; P:adult feeding behavior; IEA:Ensembl.
DR   GO; GO:0008344; P:adult locomotory behavior; IEA:Ensembl.
DR   GO; GO:0007420; P:brain development; IEA:Ensembl.
DR   GO; GO:0048589; P:developmental growth; IEA:Ensembl.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00086; homeodomain; 1.
DR   Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR003654; OAR_dom.
DR   PANTHER; PTHR46639; DIENCEPHALON/MESENCEPHALON HOMEOBOX PROTEIN 1; 1.
DR   PANTHER; PTHR46639:SF2; DIENCEPHALON/MESENCEPHALON HOMEOBOX PROTEIN 1; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   Pfam; PF03826; OAR; 1.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; Homeodomain-like; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
DR   PROSITE; PS50803; OAR; 1.
PE   3: Inferred from homology;
KW   Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW   ProRule:PRU00108};
KW   Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW   ProRule:PRU00108};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW   ProRule:PRU00108}; Reference proteome {ECO:0000313|Proteomes:UP000002277}.
FT   DOMAIN          64..124
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000259|PROSITE:PS50071"
FT   DOMAIN          354..367
FT                   /note="OAR"
FT                   /evidence="ECO:0000259|PROSITE:PS50803"
FT   DNA_BIND        66..125
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT   REGION          123..247
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        126..147
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        187..211
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   377 AA;  40675 MW;  249B93DD9F10976B CRC64;
     MQHYGVNGYS LHAMNSLNAM YNLHQQAAQQ AQHAPDYRPS VHALTLAERL ADIILEARYG
     SQHRKQRRSR TAFTAQQLEA LEKTFQKTHY PDVVMRERLA MCTNLPEARV QVWFKNRRAK
     FRKKQRSLQK EQLQKQKEAE GSHGEGKAEA PTPDTQLDTD QPPRLPGSDP PAELHLSLSE
     QSASESAPED QPDREEDPRA GAEDPKAEKS PGADSKGLGC KRGSPKADSP GSLTITPVAP
     GGGLLGPSHS YSSSPLSLFR LQEQFRQHMA ATNNLVHYSS FEVGGPAPAA AAAAAAVPYL
     GVNMAPLGSL HCQSYYQSLS AAAAAHQGVW GSPLLPAPPA GLAPASATLN SKTTSIENLR
     LRAKQHAASL GLDTLPN
//
DBGET integrated database retrieval system