ID H2R4D6_PANTR Unreviewed; 377 AA.
AC H2R4D6; A0A2J8M0B2;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 24-JAN-2024, entry version 83.
DE SubName: Full=Diencephalon/mesencephalon homeobox 1 {ECO:0000313|Ensembl:ENSPTRP00000047003.4};
GN Name=DMBX1 {ECO:0000313|Ensembl:ENSPTRP00000047003.4,
GN ECO:0000313|VGNC:VGNC:8154};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000047003.4, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000047003.4, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000047003.4}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
CC -!- SIMILARITY: Belongs to the paired homeobox family.
CC {ECO:0000256|ARBA:ARBA00005733}.
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DR EMBL; AACZ04032970; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC194746; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_524575.3; XM_524575.5.
DR AlphaFoldDB; H2R4D6; -.
DR STRING; 9598.ENSPTRP00000047003; -.
DR PaxDb; 9598-ENSPTRP00000047003; -.
DR Ensembl; ENSPTRT00000049902.4; ENSPTRP00000047003.4; ENSPTRG00000024252.4.
DR GeneID; 469190; -.
DR CTD; 127343; -.
DR VGNC; VGNC:8154; DMBX1.
DR eggNOG; KOG0490; Eukaryota.
DR GeneTree; ENSGT00940000155505; -.
DR HOGENOM; CLU_060969_0_0_1; -.
DR InParanoid; H2R4D6; -.
DR OMA; NSLNAMY; -.
DR OrthoDB; 4227585at2759; -.
DR TreeFam; TF351609; -.
DR Proteomes; UP000002277; Chromosome 1.
DR Bgee; ENSPTRG00000024252; Expressed in testis.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005667; C:transcription regulator complex; IEA:Ensembl.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IEA:Ensembl.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0008343; P:adult feeding behavior; IEA:Ensembl.
DR GO; GO:0008344; P:adult locomotory behavior; IEA:Ensembl.
DR GO; GO:0007420; P:brain development; IEA:Ensembl.
DR GO; GO:0048589; P:developmental growth; IEA:Ensembl.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR003654; OAR_dom.
DR PANTHER; PTHR46639; DIENCEPHALON/MESENCEPHALON HOMEOBOX PROTEIN 1; 1.
DR PANTHER; PTHR46639:SF2; DIENCEPHALON/MESENCEPHALON HOMEOBOX PROTEIN 1; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR Pfam; PF03826; OAR; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
DR PROSITE; PS50803; OAR; 1.
PE 3: Inferred from homology;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Reference proteome {ECO:0000313|Proteomes:UP000002277}.
FT DOMAIN 64..124
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DOMAIN 354..367
FT /note="OAR"
FT /evidence="ECO:0000259|PROSITE:PS50803"
FT DNA_BIND 66..125
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 123..247
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 126..147
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 187..211
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 377 AA; 40675 MW; 249B93DD9F10976B CRC64;
MQHYGVNGYS LHAMNSLNAM YNLHQQAAQQ AQHAPDYRPS VHALTLAERL ADIILEARYG
SQHRKQRRSR TAFTAQQLEA LEKTFQKTHY PDVVMRERLA MCTNLPEARV QVWFKNRRAK
FRKKQRSLQK EQLQKQKEAE GSHGEGKAEA PTPDTQLDTD QPPRLPGSDP PAELHLSLSE
QSASESAPED QPDREEDPRA GAEDPKAEKS PGADSKGLGC KRGSPKADSP GSLTITPVAP
GGGLLGPSHS YSSSPLSLFR LQEQFRQHMA ATNNLVHYSS FEVGGPAPAA AAAAAAVPYL
GVNMAPLGSL HCQSYYQSLS AAAAAHQGVW GSPLLPAPPA GLAPASATLN SKTTSIENLR
LRAKQHAASL GLDTLPN
//