ID H2R4F1_PANTR Unreviewed; 914 AA.
AC H2R4F1;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE RecName: Full=Solute carrier family 12 member 9 {ECO:0000256|ARBA:ARBA00019359};
GN Name=SLC12A9 {ECO:0000313|Ensembl:ENSPTRP00000047094.3,
GN ECO:0000313|VGNC:VGNC:8754};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000047094.3, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000047094.3, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000047094.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the SLC12A transporter family.
CC {ECO:0000256|ARBA:ARBA00010593}.
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DR EMBL; AC190224; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003318707.1; XM_003318659.4.
DR RefSeq; XP_009452094.1; XM_009453819.1.
DR RefSeq; XP_009452095.1; XM_009453820.2.
DR RefSeq; XP_016813399.1; XM_016957910.1.
DR AlphaFoldDB; H2R4F1; -.
DR PaxDb; 9598-ENSPTRP00000047094; -.
DR Ensembl; ENSPTRT00000036132.4; ENSPTRP00000047094.3; ENSPTRG00000019509.6.
DR GeneID; 463611; -.
DR KEGG; ptr:463611; -.
DR CTD; 56996; -.
DR VGNC; VGNC:8754; SLC12A9.
DR eggNOG; KOG1288; Eukaryota.
DR GeneTree; ENSGT00940000159400; -.
DR HOGENOM; CLU_001883_3_0_1; -.
DR InParanoid; H2R4F1; -.
DR OMA; VANVFSC; -.
DR OrthoDB; 5490251at2759; -.
DR TreeFam; TF313191; -.
DR Proteomes; UP000002277; Chromosome 7.
DR Bgee; ENSPTRG00000019509; Expressed in cerebellar cortex and 20 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015379; F:potassium:chloride symporter activity; IBA:GO_Central.
DR GO; GO:0006884; P:cell volume homeostasis; IBA:GO_Central.
DR GO; GO:0055064; P:chloride ion homeostasis; IBA:GO_Central.
DR GO; GO:1902476; P:chloride transmembrane transport; IBA:GO_Central.
DR GO; GO:0055075; P:potassium ion homeostasis; IBA:GO_Central.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR InterPro; IPR004841; AA-permease/SLC12A_dom.
DR InterPro; IPR018491; SLC12_C.
DR InterPro; IPR004842; SLC12A_fam.
DR PANTHER; PTHR11827:SF98; SOLUTE CARRIER FAMILY 12 MEMBER 9; 1.
DR PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR Pfam; PF00324; AA_permease; 1.
DR Pfam; PF03522; SLC12; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 40..60
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 72..99
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 120..144
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 164..187
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 194..214
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 263..285
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 297..319
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 339..364
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 417..439
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 451..471
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 42..535
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 547..634
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT REGION 642..678
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 844..863
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 914 AA; 96045 MW; E49B006CD68A5BF7 CRC64;
MASESSPLLA YRLLGEEGAA LPANGAGGPG GASARKLSTF LGVVVPTVLS MFSIVVFLRI
GFVVGHAGLL QALAMLLVAY FILALTVLSV CAIATNGAVQ GGGAYFMISR TLGPEVGGSI
GLMFYLANVC GCAVSLLGLV ESVLDVFGAD ATGPSGLRVL PQGYGWNLLY GSLLLGLVGG
VCTLGAGLYA RASFLTFLLV SGSLASVLIS FVAVGPRDIR LTPRPGSNGS SLPPRFGHFT
GFNSSTLKDN LGAGYAEDYT TGAVMNFASV FAVLFNGCTG IMAGANMSGE LKDPSRAIPL
GTIVAVAYTF FVYVLLFFLS SFTCDRTLLQ EDYGFFRAIS LWPPLVLIGI YATALSASMS
SLIGASRILH ALARDDLFGV ILAPAKVVSR GGNPWAAVLY SWGLVQLVLL AGKLNTLAAV
VTVFYLVAYA AVDLSCLSLE WASAPNFRPT FSLFSWHTCL LGVASCLLMM FLISPGAAGG
SLLLMGLLAA LLTARGGPSS WGYVSQALLF HQVRKYLLRL DVRKDHVKFW RPQLLLLVGN
PRGALPLLRL ANQLKKGGLY VLGHVTLGDL DSLPSDPVQP QYGAWLSLVD RAQVKAFVDL
TLSPSVRQGA QHLLRISGLG GMKPNTLVLG FYDDAPPQDH FLTDPAFSEP ADSTREGSSP
ALSTLFPPPR APGSPRALSP QDYVATVADA LKMNKNVVLA RASGALPPER LSRGSGGTSQ
LHHVDVWPLN LLRPRGGPGY VDVCGLFLLQ MATILGMVPA WHSARLRIFL CLGPREAPGA
AEGRLRALLS QLRIRAEVQE VVWGEGAGAG EPEAEEEGDF VNSGRGDAEA EALARSANAL
VRAQQGRGTG GGPGGPEGGD AEGPITALTF LYLPRPPADP ARYPRYLALL ETLTRDLGPT
LLVHGVTPVT CTDL
//
