ID H2R548_PANTR Unreviewed; 1165 AA.
AC H2R548;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 27-MAR-2024, entry version 70.
DE RecName: Full=Tectonin beta-propeller repeat-containing protein 1 {ECO:0000256|ARBA:ARBA00016409};
GN Name=TECPR1 {ECO:0000313|EMBL:JAA27014.1,
GN ECO:0000313|Ensembl:ENSPTRP00000047817.3, ECO:0000313|VGNC:VGNC:4531};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000047817.3, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000047817.3, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|EMBL:JAA27014.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Skin {ECO:0000313|EMBL:JAA27014.1};
RA Maudhoo M.D., Meehan D.T., Norgren R.B.Jr.;
RT "De novo assembly of the reference chimpanzee transcriptome from NextGen
RT mRNA sequences.";
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSPTRP00000047817.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, autophagosome membrane
CC {ECO:0000256|ARBA:ARBA00004652}. Lysosome membrane
CC {ECO:0000256|ARBA:ARBA00004656}.
CC -!- SIMILARITY: Belongs to the TECPR1 family.
CC {ECO:0000256|ARBA:ARBA00005966}.
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DR EMBL; AC187745; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; GABD01006086; JAA27014.1; -; mRNA.
DR RefSeq; XP_001135658.2; XM_001135658.3.
DR RefSeq; XP_009451946.1; XM_009453671.2.
DR RefSeq; XP_016800545.1; XM_016945056.1.
DR RefSeq; XP_016800546.1; XM_016945057.1.
DR PaxDb; 9598-ENSPTRP00000047817; -.
DR Ensembl; ENSPTRT00000055339.4; ENSPTRP00000047817.3; ENSPTRG00000028478.4.
DR Ensembl; ENSPTRT00000107921.1; ENSPTRP00000085063.1; ENSPTRG00000044396.1.
DR GeneID; 463557; -.
DR KEGG; ptr:463557; -.
DR CTD; 25851; -.
DR VGNC; VGNC:4531; TECPR1.
DR eggNOG; KOG3669; Eukaryota.
DR GeneTree; ENSGT00510000047886; -.
DR HOGENOM; CLU_008303_0_0_1; -.
DR OrthoDB; 66441at2759; -.
DR TreeFam; TF323648; -.
DR Proteomes; UP000002277; Chromosome 7.
DR Bgee; ENSPTRG00000028478; Expressed in superior frontal gyrus and 19 other cell types or tissues.
DR GO; GO:0000421; C:autophagosome membrane; IBA:GO_Central.
DR GO; GO:0005765; C:lysosomal membrane; IBA:GO_Central.
DR GO; GO:0032266; F:phosphatidylinositol-3-phosphate binding; IBA:GO_Central.
DR GO; GO:0097352; P:autophagosome maturation; IBA:GO_Central.
DR CDD; cd13300; PH1_TECPR1; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR006624; Beta-propeller_rpt_TECPR.
DR InterPro; IPR010482; Peroxin.
DR InterPro; IPR006614; Peroxin/Ferlin.
DR InterPro; IPR011993; PH-like_dom_sf.
DR PANTHER; PTHR23250; DYSFERLIN-RELATED; 1.
DR PANTHER; PTHR23250:SF1; TECTONIN BETA-PROPELLER REPEAT-CONTAINING PROTEIN 1; 1.
DR Pfam; PF06462; Hyd_WA; 4.
DR Pfam; PF06398; Pex24p; 1.
DR Pfam; PF19193; Tectonin; 1.
DR SMART; SM00694; DysFC; 2.
DR SMART; SM00693; DysFN; 2.
DR SMART; SM00706; TECPR; 11.
DR SUPFAM; SSF50729; PH domain-like; 1.
PE 2: Evidence at transcript level;
KW Lysosome {ECO:0000256|ARBA:ARBA00023228};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 64..125
FT /note="Peroxin/Ferlin"
FT /evidence="ECO:0000259|SMART:SM00693"
FT DOMAIN 137..170
FT /note="Peroxin/Ferlin"
FT /evidence="ECO:0000259|SMART:SM00694"
FT DOMAIN 816..877
FT /note="Peroxin/Ferlin"
FT /evidence="ECO:0000259|SMART:SM00693"
FT DOMAIN 888..921
FT /note="Peroxin/Ferlin"
FT /evidence="ECO:0000259|SMART:SM00694"
FT REGION 404..486
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1141..1165
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1165 AA; 129715 MW; 4D9BEA3E540EBE6E CRC64;
MPNSVLWAVD LFGRVYTLST AGQYWELCKD SQLEFKRVSA TTQCCWGIAC DNQVYVYVCA
SDVPIRRREE AYENQRWNPV GGFCEKLLLS DRWGWSDVSG LQHRLLDRVA LPSPHWEWES
DWYVDENFGG EPTEKGGWTY AIDFPATYTK DKKWNSCVRR RKWIRYRRYK SRDIWAKIPS
KDDPKELPDP FNDLSVGGWE ITEEPVGRLS VWAVSLQGKV WYREDVSHSN PEGSSWSLLD
TPGEVVQISC GPHDLLWATL WEGQALVREG INRSNPKGSS WSIVEPPGSE NGVMHVSVGV
SVVWAVTKDW KVWFRRGVNS HNPCGTSWIE MVGEMTMVNV GMNDQVWGIG CEDRAVYFRQ
GVTPSELSGK TWKAIIAARE CDRSHSGSSS SLLSAGCFFG DEVRGSGESA PSDTDASSEV
ERPGPGQTLP AEPLDDSKNA TGNSASGLGA GRTAEDTVED ACPAEGSREA RPNTHPGPAP
TPAELPWTNI DLKEAKKVPS HSAAGFPETT SLSSLGLLPL GLEEPYGVDD HPLWAWVSGG
GCVVEACAMP RWFTVQAGLS SSVHMLSLSI TPAQTAAWRK QIFQQLTERT KRELENFRHY
EQAVEQSVWV KTGALQWWCD WKPHKWVDVR LALEQFTGHD GVRDSILFIY YVVHEEKKYV
HIFLNEVVAL VPVLNETKHS FALYTPERTR QRWPVRLAAA TEQDMNDWLA LLSLSCCESR
KVQGRPSPQA IWSITCKGDI FVSEPSPDLE AYEHPLPCDQ MFWRQMGGHL RMVEANSRGV
VWGIGYDHTA WVYTGGYGGG CFQGLASSTS NIYTQSDVKC VHIYENQRWN PVTGYTSRGL
PTDRYMWSDA SGLQECTKAG TKPPSLQWAW VSDWFVDFSV PGGTDQEGWQ YASDFPASYH
GSKTMKDFVR RRCWARKCKL VTSGPWLEVP PIALRDVSII PESPGAKGSG HSIALWAISD
KGDVLCRLGV SELNPAGSSW LHVGTDQPFA SISIGACYQV WAVARDGSAF YRGSVYPSQP
AGDCWYHIPS PPRQRLKQVS VGQTSVYALD ENGNLWYRQG ITPSYPQGSS WEHVSNNVCR
VSVGPLDQVW VIANKVQGSH SLSRGTVCHR TGVQPHEPKG HGWDYGIGGG WDHISVRANA
TRAPRSLSQE QEPSAPPEAH GPVCC
//
