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Database: UniProt
Entry: H2R5K7_PANTR
LinkDB: H2R5K7_PANTR
Original site: H2R5K7_PANTR 
ID   H2R5K7_PANTR            Unreviewed;      1117 AA.
AC   H2R5K7; A0A2J8L1C0;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   08-MAY-2019, entry version 60.
DE   SubName: Full=ADAM metallopeptidase with thrombospondin type 1 motif 6 {ECO:0000313|Ensembl:ENSPTRP00000048252};
DE   SubName: Full=ADAM metallopeptidase with thrombospondin type 1 motif, 6 {ECO:0000313|EMBL:JAA03135.1};
DE   SubName: Full=ADAMTS6 isoform 1 {ECO:0000313|EMBL:PNI41063.1};
GN   Name=ADAMTS6 {ECO:0000313|EMBL:JAA03135.1,
GN   ECO:0000313|Ensembl:ENSPTRP00000048252, ECO:0000313|VGNC:VGNC:3894};
GN   ORFNames=CK820_G0034288 {ECO:0000313|EMBL:PNI41063.1};
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Pan.
OX   NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000048252, ECO:0000313|Proteomes:UP000002277};
RN   [1] {ECO:0000313|Ensembl:ENSPTRP00000048252, ECO:0000313|Proteomes:UP000002277}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16136131; DOI=10.1038/nature04072;
RG   Chimpanzee sequencing and analysis consortium;
RT   "Initial sequence of the chimpanzee genome and comparison with the
RT   human genome.";
RL   Nature 437:69-87(2005).
RN   [2] {ECO:0000313|Ensembl:ENSPTRP00000048252}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
RN   [3] {ECO:0000313|EMBL:JAA03135.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Adipose stromal {ECO:0000313|EMBL:JAA03135.1}, Skeletal muscle
RC   {ECO:0000313|EMBL:JAA40714.1}, Skin {ECO:0000313|EMBL:JAA27121.1}, and
RC   Smooth vascular {ECO:0000313|EMBL:JAA18000.1};
RA   Maudhoo M.D., Meehan D.T., Norgren R.B.Jr.;
RT   "De novo assembly of the reference chimpanzee transcriptome from
RT   NextGen mRNA sequences.";
RL   Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN   [4] {ECO:0000313|EMBL:PNI41063.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Yerkes chimp pedigree #C0471 {ECO:0000313|EMBL:PNI41063.1};
RC   TISSUE=Blood {ECO:0000313|EMBL:PNI41063.1};
RA   Pollen A., Hastie A., Hormozdiari F., Dougherty M., Liu R.,
RA   Chaisson M., Hoppe E., Hill C., Pang A., Hillier L., Baker C.,
RA   Armstrong J., Shendure J., Paten B., Wilson R., Chao H., Schneider V.,
RA   Ventura M., Kronenberg Z., Murali S., Gordon D., Cantsilieris S.,
RA   Munson K., Nelson B., Raja A., Underwood J., Diekhans M., Fiddes I.,
RA   Haussler D., Eichler E.;
RT   "High-resolution comparative analysis of great ape genomes.";
RL   Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; AACZ04069309; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AACZ04069310; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AACZ04069311; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AACZ04069312; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AACZ04069313; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AACZ04069314; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; GABC01008203; JAA03135.1; -; mRNA.
DR   EMBL; GABF01004145; JAA18000.1; -; mRNA.
DR   EMBL; GABD01005979; JAA27121.1; -; mRNA.
DR   EMBL; GABE01004025; JAA40714.1; -; mRNA.
DR   EMBL; NBAG03000320; PNI41063.1; -; Genomic_DNA.
DR   RefSeq; XP_526907.2; XM_526907.4.
DR   STRING; 9598.ENSPTRP00000048252; -.
DR   MEROPS; M12.248; -.
DR   Ensembl; ENSPTRT00000055696; ENSPTRP00000048252; ENSPTRG00000016927.
DR   GeneID; 471529; -.
DR   CTD; 11174; -.
DR   VGNC; VGNC:3894; ADAMTS6.
DR   eggNOG; KOG3538; Eukaryota.
DR   eggNOG; KOG4597; Eukaryota.
DR   eggNOG; ENOG410XPKZ; LUCA.
DR   GeneTree; ENSGT00940000156571; -.
DR   OMA; GWCYQGD; -.
DR   OrthoDB; 125522at2759; -.
DR   TreeFam; TF313537; -.
DR   Proteomes; UP000002277; Chromosome 5.
DR   Bgee; ENSPTRG00000016927; Expressed in 5 organ(s), highest expression level in heart.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR   GO; GO:0035904; P:aorta development; IEA:Ensembl.
DR   GO; GO:0003279; P:cardiac septum development; IEA:Ensembl.
DR   GO; GO:0060976; P:coronary vasculature development; IEA:Ensembl.
DR   Gene3D; 2.20.100.10; -; 5.
DR   Gene3D; 3.40.390.10; -; 1.
DR   InterPro; IPR041645; ADAM_CR_2.
DR   InterPro; IPR010294; ADAM_spacer1.
DR   InterPro; IPR013273; ADAMTS/ADAMTS-like.
DR   InterPro; IPR024079; MetalloPept_cat_dom_sf.
DR   InterPro; IPR001590; Peptidase_M12B.
DR   InterPro; IPR002870; Peptidase_M12B_N.
DR   InterPro; IPR010909; PLAC.
DR   InterPro; IPR000884; TSP1_rpt.
DR   InterPro; IPR036383; TSP1_rpt_sf.
DR   Pfam; PF17771; ADAM_CR_2; 1.
DR   Pfam; PF05986; ADAM_spacer1; 1.
DR   Pfam; PF01562; Pep_M12B_propep; 1.
DR   Pfam; PF08686; PLAC; 1.
DR   Pfam; PF01421; Reprolysin; 1.
DR   Pfam; PF00090; TSP_1; 5.
DR   PRINTS; PR01857; ADAMTSFAMILY.
DR   SMART; SM00209; TSP1; 5.
DR   SUPFAM; SSF82895; SSF82895; 5.
DR   PROSITE; PS50215; ADAM_MEPRO; 1.
DR   PROSITE; PS50900; PLAC; 1.
DR   PROSITE; PS50092; TSP1; 4.
PE   2: Evidence at transcript level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002277};
KW   Disulfide bond {ECO:0000256|SAAS:SAAS00117091};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     17       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        18   1117       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5015093339.
FT   DOMAIN      250    468       Peptidase M12B. {ECO:0000259|PROSITE:
FT                                PS50215}.
FT   DOMAIN     1079   1117       PLAC. {ECO:0000259|PROSITE:PS50900}.
SQ   SEQUENCE   1117 AA;  125257 MW;  4941E86BD4369A9B CRC64;
     MEILWKTLTW ILSLIMASSE FHSDHRLSYS SQEEFLTYLE HYQLTIPIRV DQNGAFLSFT
     VKNDKHSRRR RSMDPIDPQQ AVSKLFFKLS AYGKHFHLNL TLNTDFVSKH FTVEYWGKDG
     PQWKHDFLDN CHYTGYLQDQ RSTTKVALSN CVGLHGVIAT EDEEYFIEPL KNTTEDSKHF
     SYENGHPHVI YKKSALQQRH LYDHSHCGVS DFTRSGKPWW LNDTSTVSYS LPINNTHIHH
     RQKRSVSIER FVETLVVADK MMVGYHGRKD IEHYILSVMN IVAKLYRDSS LGNVVNIIVA
     RLIVLTEDQP NLEINHHADK SLDSFCKWQK SILSHQSDGN TIPENGIAHH DNAVLITRYD
     ICTYKNKPCG TLGLASVAGM CEPERSCSIN EDIGLGSAFT IAHEIGHNFG MNHDGIGNSC
     GTKGHEAAKL MAAHITANTN PFSWSACSRD YITSFLDSGR GTCLDNEPPK RDFLYPAVAP
     GQVYDADEQC RFQYGATSRQ CKYGEVCREL WCLSKSNRCV TNSIPAAEGT LCQTGNIEKG
     WCYQGDCVPF GTWPQSIDGG WGPWSLWGEC SRTCGGGVSS SLRHCDSPAP SGGGKYCLGE
     RKRYRSCNTD PCPLGSRDFR EKQCADFDNM PFRGKYYNWK PYTGGGVKPC ALNCLAEGYN
     FYTERAPAVI DGTQCNADSL DICINGECKH VGCDNILGSD AREDRCRVCG GDGSTCDAIE
     GFFNDSLPRG GYMEVVQIPR GSVHIEVREV AMSKNYIALK SEGDDYYING AWTIDWPRKF
     DVAGTAFHYK RPTDEPESLE ALGPTSENLI VMVLLQEQNL GIRYKFNVPI TRTGSGDNEV
     GFTWNHQPWS ECSATCAGGV QRQEVVCKRL DDNSIVQNNY CDPDSKPPEN QRACNTEPCP
     PEWFIGDWLE CSKTCDGGMR TRAVLCIRKI GPSEEETLDY SGCLTHRPVE KEPCNNQSCP
     PQWVALDWSE CTPKCGPGFK HRIVLCKSSD LSKTFPAAQC PEESKPPVRI RCSLGRCPPP
     RWVTGDWGQC SAQCGLGQQM RTVQCLSYTG QASSDCPETV RPPSMQQCES KCDSTPISNT
     EECKDVNKVA YCPLVLKFKF CSRAYFRQMC CKTCQGH
//
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