ID H2R6T3_PANTR Unreviewed; 1801 AA.
AC H2R6T3;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 77.
DE RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
GN Name=PTPRD {ECO:0000313|Ensembl:ENSPTRP00000049466.3,
GN ECO:0000313|VGNC:VGNC:9193};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000049466.3, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000049466.3, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000049466.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620; EC=3.1.3.48;
CC Evidence={ECO:0000256|ARBA:ARBA00001490};
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family.
CC Receptor class 2A subfamily. {ECO:0000256|ARBA:ARBA00010504}.
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DR EMBL; AACZ04057672; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR PaxDb; 9598-ENSPTRP00000049466; -.
DR Ensembl; ENSPTRT00000046073.4; ENSPTRP00000049466.3; ENSPTRG00000020773.7.
DR VGNC; VGNC:9193; PTPRD.
DR eggNOG; KOG4228; Eukaryota.
DR GeneTree; ENSGT00940000153617; -.
DR HOGENOM; CLU_001645_4_3_1; -.
DR InParanoid; H2R6T3; -.
DR TreeFam; TF312900; -.
DR Proteomes; UP000002277; Chromosome 9.
DR Bgee; ENSPTRG00000020773; Expressed in temporal lobe and 20 other cell types or tissues.
DR GO; GO:0098978; C:glutamatergic synapse; IEA:Ensembl.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IBA:GO_Central.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR GO; GO:0099054; P:presynapse assembly; IEA:Ensembl.
DR GO; GO:0099560; P:synaptic membrane adhesion; IBA:GO_Central.
DR GO; GO:0099545; P:trans-synaptic signaling by trans-synaptic complex; IEA:Ensembl.
DR CDD; cd00063; FN3; 8.
DR CDD; cd05738; IgI_2_RPTP_IIa_LAR_like; 1.
DR CDD; cd05739; IgI_3_RPTP_IIa_LAR_like; 1.
DR CDD; cd14624; R-PTPc-D-1; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 11.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 2.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR045905; R-PTP-delta_cat.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR46957; CYTOKINE RECEPTOR; 1.
DR PANTHER; PTHR46957:SF8; PROTEIN TYROSINE PHOSPHATASE RECEPTOR TYPE S; 1.
DR Pfam; PF00041; fn3; 7.
DR Pfam; PF07679; I-set; 2.
DR Pfam; PF13927; Ig_3; 1.
DR Pfam; PF00102; Y_phosphatase; 2.
DR PRINTS; PR00014; FNTYPEIII.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00060; FN3; 8.
DR SMART; SM00409; IG; 4.
DR SMART; SM00408; IGc2; 3.
DR SMART; SM00194; PTPc; 2.
DR SMART; SM00404; PTPc_motif; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 2.
DR SUPFAM; SSF49265; Fibronectin type III; 5.
DR SUPFAM; SSF48726; Immunoglobulin; 3.
DR PROSITE; PS50853; FN3; 7.
DR PROSITE; PS50835; IG_LIKE; 3.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 2.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..1801
FT /note="protein-tyrosine-phosphatase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014192550"
FT TRANSMEM 1254..1277
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 24..114
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 126..215
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 223..305
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 312..402
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 407..503
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 505..594
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 599..696
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 701..809
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 810..903
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 908..1003
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1344..1599
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1519..1590
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT DOMAIN 1631..1781
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT REGION 590..610
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1285..1305
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1801 AA; 202342 MW; A471D2B99ED34FFC CRC64;
MVHVARLLLL LLTFFLRTDA ETPPRFTRTP VDQTGVSGGV ASFICQATGD PRPKIVWNKK
GKKVSNQRFE VIEFDDGSGS VLRIQPLRTP RDEAIYECVA SNNVGEISVS TRLTVLREDQ
IPRGFPTIDM GPQLKVVERT RTATMLCAAS GNPDPEITWF KDFLPVDTSN NNGRIKQLRS
GALQIEQSEE SDQGKYECVA TNSAGTRYSA PANLYVRVRR VPPRFSIPPT NHEIMPGGSV
NITCVAVGSP MPYVKWMLGA EDLTPEDDMP IGRNVLELND VRQSANYTCV AMSTLGVIEA
IAQITVKALP KPPGTPVVTE STATSITLTW DSGNPEPVSY YIIQHKPKNS EEPYKEIDGV
ATTRYSVAGL SPYSDYEFRV VAVNNIGRGP PSEPVLTQTS EQAPSSAPRD VQARMLSSTT
ILVQWKEPEE PNGQIQGYRV YYTMDPTQHV NNWMKHNVAD SQITTIGNLV PQKTYSVKVL
AFTSIGDGPL SSDIQVITQT GVPGQPLNFK AEPESETSIL LSWTPPRSDT IANYELVYKD
GEHGEEQRIT IEPGTSYRLQ GLKPNSLYYF RLAARSPQGL GASTAEISAR TMQSKPSAPP
QDISCTSPSS TSILVSWQPP PVEKQNGIIT EYSIKYTAVD GEDDKPHEIL GIPSDTTKYL
LEQLEKWTEY RITVTAHTDV GPGPESLSVL IRTNEDVPSG PPRKVEVEAV NSTSVKVSWR
SPVPNKQHGQ IRGYQVHYVR MENGEPKGQP MLKDVMLADA QWEFDDTTEH DMIISGLQPE
TSYSLTVTAY TTKGDGARSK PKLVSTTGAV PGKPRLVINH TQMNTALIQW HPPVDTFGPL
QGYRLKFGRK DMEPLTTLEF SEKEDHFTAT DIHKGASYVF RLSARNKVGF GEEMVKEISI
PEEVPTGFPQ NLHSEGTTST SVQLSWQPPV LAERNGIITK YTLLYRDINI PLLPMEQLIV
PADTTMTLTG LKPDTTYDVK VRAHTSKGPG PYSPSVQFRT LPVDQVFAKN FHVKAVMKTS
VLLSWEIPEN YNSAMPFKIL YDDGKMVEEV DGRATQKLIV NLKPEKSYSF VLTNRGNSAG
GLQHRVTAKT APDVLRTKPA FIGKTNLDGM ITVQLPEVPA NENIKGYYII IVPLKKSRGK
FIKPWESPDE MELDELLKEI SRKRRSIRYG REVELKPYIA AHFDVLPTEF TLGDDKHYGG
FTNKQLQSGQ EYVFFVLAVM EHAESKMYAT SPYSDPVVSM DLDPQPITDE EEGLIWVVGP
VLAVVFIICI VIAILLYKRK RAESDSRKSS IPNNKEIPSH HPTDPVELRR LNFQTPGMAS
HPPIPILELA DHIERLKAND NLKFSQEYES IDPGQQFTWE HSNLEVNKPK NRYANVIAYD
HSRVLLSAIE GIPGSDYVNA NYIDGYRKQN AYIATQGSLP ETFGDFWRMI WEQRSATVVM
MTKLEERSRV KCDQYWPSRG TETHGLVQVT LLDTVELATY CVRTFALYKN GSSEKREVRQ
FQFTAWPDHG VPEHPTPFLA FLRRVKTCNP PDAGPMVVHC SAGVGRTGCF IVIDAMLERI
KHEKTVDIYG HVTLMRAQRN YMVQTEDQYI FIHDALLEAV TCGNTEVPAR NLYAYIQKLT
QIETGENVTG MELEFKRLAS SKAHTSRFIS ANLPCNKFKN RLVNIMPYES TRVCLQPIRG
VEGSDYINAS FIDGYRQQKA YIATQGPLAE TTEDFWRMLW EHNSTIVVML TKLREMGREK
CHQYWPAERS ARYQYFVVDP MAEYNMPQYI LREFKVTDAR RGRWKNWSLH NAKHCFGKNE
I
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