ID H2R7I5_PANTR Unreviewed; 516 AA.
AC H2R7I5;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=ZFP57 zinc finger protein {ECO:0000313|Ensembl:ENSPTRP00000050454.2};
GN Name=ZFP57 {ECO:0000313|Ensembl:ENSPTRP00000050454.2,
GN ECO:0000313|VGNC:VGNC:12749};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000050454.2, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000050454.2, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000050454.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000256|ARBA:ARBA00006991}.
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DR EMBL; AACZ04022776; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H2R7I5; -.
DR Ensembl; ENSPTRT00000057561.2; ENSPTRP00000050454.2; ENSPTRG00000017904.5.
DR VGNC; VGNC:12749; ZFP57.
DR GeneTree; ENSGT00390000002599; -.
DR HOGENOM; CLU_002678_0_7_1; -.
DR OMA; HQQTHWR; -.
DR Proteomes; UP000002277; Chromosome 6.
DR Bgee; ENSPTRG00000017904; Expressed in dorsolateral prefrontal cortex and 14 other cell types or tissues.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd07765; KRAB_A-box; 1.
DR Gene3D; 6.10.140.140; -; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 6.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR23232; KRAB DOMAIN C2H2 ZINC FINGER; 1.
DR PANTHER; PTHR23232:SF130; RIKEN CDNA 1700020N01 GENE-RELATED; 1.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 6.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 7.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 4.
DR SUPFAM; SSF109640; KRAB domain (Kruppel-associated box); 1.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 6.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 7.
PE 3: Inferred from homology;
KW Isopeptide bond {ECO:0000256|ARBA:ARBA00022499};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00042}.
FT DOMAIN 24..96
FT /note="KRAB"
FT /evidence="ECO:0000259|PROSITE:PS50805"
FT DOMAIN 155..182
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 183..210
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 211..238
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 239..266
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 364..391
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 392..419
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 420..447
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT REGION 474..516
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 516 AA; 59280 MW; 33890644C61656F9 CRC64;
MFEQLKPIEP RDCWREARVK KKPVTFEDVA VNFTQEEWDC LDASQRVLYQ DVMSETFKNL
ISVARIFLHK PELITKLEQE EEQWREFVHL PNTEGLSEGK KKELREQHPS LRDEGTSDDK
VFLARRGAGQ CPLSAPAGSM DRTRVLQASQ AGPPFFCHTC GKCFSRRSYL YSHQFVHNPK
LTNSCSQCGK LFRSPKSLSY HRRMHLGERP FCCTLCDKTY CDASGLSRHR RVHLGYRPHS
CSVCGKSFRD QSELKRHQKI HQNQEPVDGN QECTLRIPGT RAEFQTPIAR SQRSIQGLLD
VNHAPVARSQ EPIFRTEGPM AQNQPSVLKN QAPVTRTQAP ITGTLCQDAR SNSHPVKPSR
LNVFCCPHCP LTFSKKSYLS RHQKAHLTEP PNYCFHCSKS FSSFSRLVRH QQTHWKQKSY
LCPICDLSFG EKEGLMDHWR GYKGKELCQS SHHKCRVILG QWLGFSHDVP TMAGEEWKHG
GDQSPPRIHT PRRRGLREKA CKGDKTKEAV SILKHK
//
