ID H2R7J0_PANTR Unreviewed; 220 AA.
AC H2R7J0;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE RecName: Full=Glutathione peroxidase {ECO:0000256|ARBA:ARBA00012310, ECO:0000256|RuleBase:RU000499};
GN Name=GPX6 {ECO:0000313|Ensembl:ENSPTRP00000050465.1,
GN ECO:0000313|VGNC:VGNC:2850};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000050465.1, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000050465.1, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000050465.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the glutathione peroxidase family.
CC {ECO:0000256|ARBA:ARBA00006926, ECO:0000256|RuleBase:RU000499}.
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DR EMBL; AACZ04022771; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H2R7J0; -.
DR PaxDb; 9598-ENSPTRP00000050465; -.
DR Ensembl; ENSPTRT00000033001.4; ENSPTRP00000050465.1; ENSPTRG00000017878.6.
DR VGNC; VGNC:2850; GPX6.
DR eggNOG; KOG1651; Eukaryota.
DR GeneTree; ENSGT00940000161098; -.
DR HOGENOM; CLU_029507_2_1_1; -.
DR InParanoid; H2R7J0; -.
DR OMA; VMRWHPR; -.
DR TreeFam; TF105318; -.
DR Proteomes; UP000002277; Chromosome 6.
DR Bgee; ENSPTRG00000017878; Expressed in lung.
DR GO; GO:0004602; F:glutathione peroxidase activity; IBA:GO_Central.
DR GO; GO:0006979; P:response to oxidative stress; IEA:InterPro.
DR CDD; cd00340; GSH_Peroxidase; 1.
DR Gene3D; 3.40.30.10; Glutaredoxin; 1.
DR InterPro; IPR000889; Glutathione_peroxidase.
DR InterPro; IPR029760; GPX_CS.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR PANTHER; PTHR11592; GLUTATHIONE PEROXIDASE; 1.
DR PANTHER; PTHR11592:SF15; GLUTATHIONE PEROXIDASE 6; 1.
DR Pfam; PF00255; GSHPx; 1.
DR PIRSF; PIRSF000303; Glutathion_perox; 1.
DR PRINTS; PR01011; GLUTPROXDASE.
DR SUPFAM; SSF52833; Thioredoxin-like; 1.
DR PROSITE; PS00763; GLUTATHIONE_PEROXID_2; 1.
DR PROSITE; PS51355; GLUTATHIONE_PEROXID_3; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|RuleBase:RU000499};
KW Peroxidase {ECO:0000256|ARBA:ARBA00022559, ECO:0000256|RuleBase:RU000499};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..220
FT /note="Glutathione peroxidase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003570593"
SQ SEQUENCE 220 AA; 24823 MW; 3BE41AB09AE01216 CRC64;
MFRQFQASCL VLLFLVGFAQ QILKPQNRKV DCNKGVTGTI YEYGALTLNG EEYIQFKQFA
GKHVLFVNVA TYGLAAQYPE LNALQEELKN FGVIVLAFPC NQFGKQEPGT NSEILLGLKY
VCPGSGFVPS FQLFEKGDVN GEKEQKVFTF LKNSCPPTSD LLGSSSQLFW EPMKVHDICW
NFEKFLVGPD GVPVMRWFHQ APVSTVKSDI LEYLKQFNTH
//
