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Database: UniProt
Entry: H2R800_PANTR
LinkDB: H2R800_PANTR
Original site: H2R800_PANTR 
ID   H2R800_PANTR            Unreviewed;       761 AA.
AC   H2R800;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 2.
DT   20-JUN-2018, entry version 48.
DE   SubName: Full=Transient receptor potential cation channel subfamily C member 1 {ECO:0000313|Ensembl:ENSPTRP00000051014};
GN   Name=TRPC1 {ECO:0000313|Ensembl:ENSPTRP00000051014,
GN   ECO:0000313|VGNC:VGNC:8016};
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Pan.
OX   NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000051014, ECO:0000313|Proteomes:UP000002277};
RN   [1] {ECO:0000313|Ensembl:ENSPTRP00000051014, ECO:0000313|Proteomes:UP000002277}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16136131; DOI=10.1038/nature04072;
RG   Chimpanzee sequencing and analysis consortium;
RT   "Initial sequence of the chimpanzee genome and comparison with the
RT   human genome.";
RL   Nature 437:69-87(2005).
RN   [2] {ECO:0000313|Ensembl:ENSPTRP00000051014}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the transient receptor (TC 1.A.4) family.
CC       {ECO:0000256|SAAS:SAAS01006510}.
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DR   EMBL; AACZ04048237; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 9598.ENSPTRP00000051014; -.
DR   Ensembl; ENSPTRT00000028891; ENSPTRP00000051014; ENSPTRG00000015485.
DR   VGNC; VGNC:8016; TRPC1.
DR   eggNOG; KOG3609; Eukaryota.
DR   eggNOG; ENOG410XQ0Y; LUCA.
DR   GeneTree; ENSGT00760000119180; -.
DR   OMA; PKTICYL; -.
DR   OrthoDB; EOG091G029I; -.
DR   TreeFam; TF313147; -.
DR   Proteomes; UP000002277; Chromosome 3.
DR   Bgee; ENSPTRG00000015485; -.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0015279; F:store-operated calcium channel activity; IBA:GO_Central.
DR   GO; GO:0006828; P:manganese ion transport; IBA:GO_Central.
DR   GO; GO:0051480; P:regulation of cytosolic calcium ion concentration; IBA:GO_Central.
DR   CDD; cd00204; ANK; 1.
DR   Gene3D; 1.25.40.20; -; 1.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR020683; Ankyrin_rpt-contain_dom.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR004729; TRP_channel.
DR   InterPro; IPR013555; TRP_dom.
DR   InterPro; IPR005457; TRPC1_channel.
DR   InterPro; IPR002153; TRPC_channel.
DR   PANTHER; PTHR10117; PTHR10117; 2.
DR   PANTHER; PTHR10117:SF56; PTHR10117:SF56; 2.
DR   Pfam; PF12796; Ank_2; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF08344; TRP_2; 1.
DR   PRINTS; PR01097; TRNSRECEPTRP.
DR   PRINTS; PR01642; TRPCHANNEL1.
DR   SMART; SM00248; ANK; 3.
DR   SUPFAM; SSF48403; SSF48403; 1.
DR   TIGRFAMs; TIGR00870; trp; 1.
PE   3: Inferred from homology;
KW   ANK repeat {ECO:0000256|SAAS:SAAS00933366};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002277};
KW   Ion channel {ECO:0000256|SAAS:SAAS00790162};
KW   Ion transport {ECO:0000256|SAAS:SAAS00790154};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW   Repeat {ECO:0000256|SAAS:SAAS00931009};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|SAAS:SAAS00788392}.
FT   TRANSMEM    319    339       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    355    375       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    505    527       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    555    576       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    588    610       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       55    149       ANK_REP_REGION. {ECO:0000259|Pfam:
FT                                PF12796}.
FT   DOMAIN      161    223       TRP_2. {ECO:0000259|Pfam:PF08344}.
FT   DOMAIN      362    624       Ion_trans. {ECO:0000259|Pfam:PF00520}.
SQ   SEQUENCE   761 AA;  87740 MW;  64208325219386A3 CRC64;
     AAMMAALYPS TDLSGASSSS LPSSPSSSSP NEVMALKDVR EVKEENTLNE KLFLLACDKG
     DYYMVKKILE ENSSGDLNIN CVDVLGRNAV TITIENENLD ILQLLLDYGC QKLMERIQNP
     EYSTTMDVAP VILAAHHNNY EILTMLLKQD VSLPKPHAVG CECTLCSAKN KKDSLRHSRF
     RLDIYRCLAS PALIMLTEED PILRAFELSA DLKELSLVEV EFRNDYEELA RQCKMFAKDL
     LAQARNSREL EVILNHTSSD EPLDKRGLLE ERMNLSRLKL AIKYNQKEFV SQSNCQQFLN
     TVWFGQMSGY RRKPTCKKIM TVLTVGIFWP VLSLCYLIAP KSQFGRIIHT PFMKFIIHGA
     SYFTFLLLLN LYSLVYNEDK KNTMGPALER IDYLLILWII GMIWSDIKRL WYEGLEDFLE
     ESRNQLSFVM NSLYLATFAL KVVAHNKFHD FADRKDWDAF HPTLVAEGLF AFANVLSYLR
     LFFMYTTSSI LGPLQISMGQ MLQDFGKFLG MFLLVLFSFT IGLTQLYDKG YTSKEQKDCV
     GIFCEQQSND TFHSFIGTCF ALFWYIFSLA HVAIFVTRFS YGEELQSFVG AVIVGTYNVV
     VVIVLTKLLV AMLHKSFQLI ANHEDKEWKF ARAKLWLSYF DDKCTLPPPF NIIPSPKTIC
     YMISSLSKWI CSHTSKGKVK RQNSLKEWRN LKQKRDENYQ KVMCCLVHRY LTSMRQKMQS
     TDQATVENLN ELRQDLSKFR NEIRDLLGFR TSKYAMFYPR N
//
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