ID H2R8N8_PANTR Unreviewed; 259 AA.
AC H2R8N8; A0A2J8IUC9;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 52.
DE RecName: Full=Sulfotransferase {ECO:0000256|RuleBase:RU361155};
DE EC=2.8.2.- {ECO:0000256|RuleBase:RU361155};
GN Name=SULT1C2 {ECO:0000313|Ensembl:ENSPTRP00000051789.4,
GN ECO:0000313|VGNC:VGNC:10778};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000051789.4, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000051789.4, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000051789.4}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=3'-phosphoadenylyl sulfate + a phenol = adenosine 3',5'-
CC bisphosphate + an aryl sulfate + H(+); Xref=Rhea:RHEA:12164,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:33853, ChEBI:CHEBI:58339,
CC ChEBI:CHEBI:58343, ChEBI:CHEBI:140317; EC=2.8.2.1;
CC Evidence={ECO:0000256|ARBA:ARBA00036572};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Lysosome {ECO:0000256|ARBA:ARBA00004371}.
CC -!- SIMILARITY: Belongs to the sulfotransferase 1 family.
CC {ECO:0000256|ARBA:ARBA00005771, ECO:0000256|RuleBase:RU361155}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AACZ04003626; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H2R8N8; -.
DR Ensembl; ENSPTRT00000022880.6; ENSPTRP00000051789.4; ENSPTRG00000024324.5.
DR VGNC; VGNC:10778; SULT1C2.
DR eggNOG; KOG1584; Eukaryota.
DR GeneTree; ENSGT00940000160912; -.
DR HOGENOM; CLU_027239_6_1_1; -.
DR TreeFam; TF321745; -.
DR Proteomes; UP000002277; Chromosome 2A.
DR Bgee; ENSPTRG00000024324; Expressed in adult mammalian kidney and 15 other cell types or tissues.
DR GO; GO:0005764; C:lysosome; IEA:UniProtKB-SubCell.
DR GO; GO:0004062; F:aryl sulfotransferase activity; IEA:RHEA.
DR GO; GO:0051923; P:sulfation; IEA:UniProt.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000863; Sulfotransferase_dom.
DR PANTHER; PTHR11783:SF73; SULFOTRANSFERASE 1C2; 1.
DR PANTHER; PTHR11783; SULFOTRANSFERASE SULT; 1.
DR Pfam; PF00685; Sulfotransfer_1; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU361155}.
FT DOMAIN 39..86
FT /note="Sulfotransferase"
FT /evidence="ECO:0000259|Pfam:PF00685"
FT DOMAIN 93..251
FT /note="Sulfotransferase"
FT /evidence="ECO:0000259|Pfam:PF00685"
SQ SEQUENCE 259 AA; 30657 MW; 0D04D944AFAADB06 CRC64;
MALTSDLGKQ IKLKEVEGTL LQPATVDNWS QIQSFEAKPD DLLICTYPKA GTTWIQEIVD
MIEQNGDVEK CQRAIIQHRH PFIEWARPPQ PSARNAKDCM VSYYHFQRMN HMLPDPGTWE
EYFETFINGK VVWGSWFDHV KGWWEMKDRH QILFLFYEDI KRDPKHEIRK VMQFMGKNVD
ETVLDKIVQE TSFEKMKENP MTNRSTVSKS IMDQSISSFM RKGTVGDWKN HFTVAQNERF
DEIYRRKMEG TSINFCMEL
//
