ID H2RAD4_PANTR Unreviewed; 161 AA.
AC H2RAD4; A0A2J8L9U8;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=Lipopolysaccharide-induced TNF factor {ECO:0000313|EMBL:JAA07730.1, ECO:0000313|Ensembl:ENSPTRP00000053768.3};
GN Name=LITAF {ECO:0000313|EMBL:JAA07730.1,
GN ECO:0000313|Ensembl:ENSPTRP00000053768.3, ECO:0000313|VGNC:VGNC:9085};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000053768.3, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000053768.3, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|EMBL:JAA07730.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Adipose stromal {ECO:0000313|EMBL:JAA07730.1}, and Smooth
RC vascular {ECO:0000313|EMBL:JAA12430.1};
RA Maudhoo M.D., Meehan D.T., Norgren R.B.Jr.;
RT "De novo assembly of the reference chimpanzee transcriptome from NextGen
RT mRNA sequences.";
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSPTRP00000053768.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004413};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004413};
CC Cytoplasmic side {ECO:0000256|ARBA:ARBA00004413}. Cytoplasm
CC {ECO:0000256|ARBA:ARBA00004496}. Early endosome membrane
CC {ECO:0000256|ARBA:ARBA00004146}. Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004125}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004125}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004125}. Golgi apparatus membrane
CC {ECO:0000256|ARBA:ARBA00004394}. Late endosome membrane
CC {ECO:0000256|ARBA:ARBA00004414}. Lysosome membrane
CC {ECO:0000256|ARBA:ARBA00004630}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004630}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004630}. Membrane
CC {ECO:0000256|ARBA:ARBA00004370}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the CDIP1/LITAF family.
CC {ECO:0000256|ARBA:ARBA00005975}.
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DR EMBL; AACZ04032091; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; GABC01003608; JAA07730.1; -; mRNA.
DR EMBL; GABF01009715; JAA12430.1; -; mRNA.
DR RefSeq; XP_001142807.1; XM_001142807.3.
DR RefSeq; XP_001142883.1; XM_001142883.5.
DR RefSeq; XP_001142957.1; XM_001142957.4.
DR RefSeq; XP_009428586.1; XM_009430311.2.
DR RefSeq; XP_009428587.1; XM_009430312.2.
DR STRING; 9598.ENSPTRP00000053768; -.
DR PaxDb; 9598-ENSPTRP00000053768; -.
DR Ensembl; ENSPTRT00000060391.4; ENSPTRP00000053768.3; ENSPTRG00000007772.6.
DR GeneID; 453923; -.
DR KEGG; ptr:453923; -.
DR CTD; 9516; -.
DR VGNC; VGNC:9085; LITAF.
DR eggNOG; ENOG502S2GM; Eukaryota.
DR GeneTree; ENSGT00940000155366; -.
DR HOGENOM; CLU_095549_3_0_1; -.
DR OMA; VTFYDRP; -.
DR OrthoDB; 1383925at2759; -.
DR TreeFam; TF313294; -.
DR Proteomes; UP000002277; Chromosome 16.
DR Bgee; ENSPTRG00000007772; Expressed in liver and 22 other cell types or tissues.
DR GO; GO:0098559; C:cytoplasmic side of early endosome membrane; IEA:Ensembl.
DR GO; GO:0098560; C:cytoplasmic side of late endosome membrane; IBA:GO_Central.
DR GO; GO:0098574; C:cytoplasmic side of lysosomal membrane; IBA:GO_Central.
DR GO; GO:0009898; C:cytoplasmic side of plasma membrane; IEA:Ensembl.
DR GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:Ensembl.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:Ensembl.
DR GO; GO:0050699; F:WW domain binding; IEA:Ensembl.
DR GO; GO:0008270; F:zinc ion binding; IBA:GO_Central.
DR GO; GO:0071222; P:cellular response to lipopolysaccharide; IEA:Ensembl.
DR GO; GO:1901223; P:negative regulation of non-canonical NF-kappaB signal transduction; IEA:Ensembl.
DR GO; GO:0001817; P:regulation of cytokine production; IBA:GO_Central.
DR GO; GO:0010935; P:regulation of macrophage cytokine production; IEA:Ensembl.
DR InterPro; IPR006629; LITAF.
DR InterPro; IPR037519; LITAF_fam.
DR PANTHER; PTHR23292; LIPOPOLYSACCHARIDE-INDUCED TUMOR NECROSIS FACTOR-ALPHA FACTOR; 1.
DR PANTHER; PTHR23292:SF2; LIPOPOLYSACCHARIDE-INDUCED TUMOR NECROSIS FACTOR-ALPHA FACTOR; 1.
DR Pfam; PF10601; zf-LITAF-like; 1.
DR SMART; SM00714; LITAF; 1.
DR PROSITE; PS51837; LITAF; 1.
PE 2: Evidence at transcript level;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW Lysosome {ECO:0000256|ARBA:ARBA00023228};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 76..160
FT /note="LITAF"
FT /evidence="ECO:0000259|PROSITE:PS51837"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7..22
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 161 AA; 17093 MW; 106AF8F1FDD89460 CRC64;
MSVPGPYQAA TGPSSAPSAP PSYEETVAVN SYYPTPPAPM PGPTTGLVTG PDGKGMNPPS
YYTQPAPIPN NNPITVQTVY VQHPITFLDR PVQMCCPSCN KMIVSQLSYN AGALTWLSCG
SLCLLGCIAG CCFIPFCVDA LQDVDHYCPN CRALLGTYKR L
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