ID H2RAZ8_PANTR Unreviewed; 271 AA.
AC H2RAZ8; A0A2J8LWH3;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=Intercellular adhesion molecule 4 {ECO:0000313|Ensembl:ENSPTRP00000054779.3};
GN Name=ICAM4 {ECO:0000313|Ensembl:ENSPTRP00000054779.3,
GN ECO:0000313|VGNC:VGNC:2352};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000054779.3, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000054779.3, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000054779.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the immunoglobulin superfamily. ICAM family.
CC {ECO:0000256|ARBA:ARBA00005925}.
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DR EMBL; AACZ04030711; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H2RAZ8; -.
DR Ensembl; ENSPTRT00000062225.3; ENSPTRP00000054779.3; ENSPTRG00000022810.6.
DR VGNC; VGNC:2352; ICAM4.
DR GeneTree; ENSGT00940000162431; -.
DR HOGENOM; CLU_1165526_0_0_1; -.
DR OMA; QPVICHT; -.
DR TreeFam; TF333745; -.
DR Proteomes; UP000002277; Chromosome 19.
DR Bgee; ENSPTRG00000022810; Expressed in lung and 14 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005178; F:integrin binding; IEA:InterPro.
DR GO; GO:0098609; P:cell-cell adhesion; IEA:InterPro.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR InterPro; IPR013768; ICAM_N.
DR InterPro; IPR047012; ICAM_VCAM.
DR InterPro; IPR003987; ICAM_VCAM_N.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR PANTHER; PTHR13771; INTERCELLULAR ADHESION MOLECULE; 1.
DR PANTHER; PTHR13771:SF8; INTERCELLULAR ADHESION MOLECULE 4; 1.
DR Pfam; PF03921; ICAM_N; 1.
DR PRINTS; PR01472; ICAMVCAM1.
DR SUPFAM; SSF48726; Immunoglobulin; 2.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..271
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5015093442"
FT TRANSMEM 240..262
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 48..135
FT /note="Intercellular adhesion molecule N-terminal"
FT /evidence="ECO:0000259|Pfam:PF03921"
SQ SEQUENCE 271 AA; 29198 MW; 8FB0B083AA3810C4 CRC64;
MGSLFPLSLL FFLAAAYPGV GSALGRRTKR AQGPKGSPLA PSGTSVPFWV RMSPEFVAVQ
PGKSVQLNCS NSCPQPQNSS LRTPLRQGKT LTGPGWVSYQ LLDVRAWSSL AHCLVTCAGK
TRWATSRITA YKPPHSVILE PPVLKGRKYT LRCHVTQVFP VGYLVVTLRH GSRVIYSESL
ERFTGLDLAN VTLTYEFAAG PRDFWQPVIC HARLNLDGLV VRNSSAPITL MLAWSSAPTA
LASVSIAALV GILLTVGAAY VCKCLAMKSQ A
//
