UniProt: H2RC69

Database: UniProt
Entry: H2RC69_PANTR

LinkDB:  H2RC69_PANTR 
Original site:  H2RC69_PANTR

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Ontology (10)   
   GO (10)   
Gene (4)   
   KEGG GENES (1)   
   ENSEMBL-UP (3)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   EMBL (1)   
Protein domain (32)   
   InterPro (19)   
   Pfam (12)   
   SMART (1)   
Literature (1)   
   PubMed (1)   
All databases (49)   

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ID   H2RC69_PANTR            Unreviewed;      4532 AA.
AC   H2RC69;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 2.
DT   27-MAR-2024, entry version 74.
DE   SubName: Full=Dynein axonemal heavy chain 10 {ECO:0000313|Ensembl:ENSPTRP00000056845.3};
GN   Name=DNAH10 {ECO:0000313|Ensembl:ENSPTRP00000056845.3,
GN   ECO:0000313|VGNC:VGNC:13012};
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pan.
OX   NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000056845.3, ECO:0000313|Proteomes:UP000002277};
RN   [1] {ECO:0000313|Ensembl:ENSPTRP00000056845.3, ECO:0000313|Proteomes:UP000002277}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16136131; DOI=10.1038/nature04072;
RG   Chimpanzee sequencing and analysis consortium;
RT   "Initial sequence of the chimpanzee genome and comparison with the human
RT   genome.";
RL   Nature 437:69-87(2005).
RN   [2] {ECO:0000313|Ensembl:ENSPTRP00000056845.3}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC       {ECO:0000256|ARBA:ARBA00008887}.
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DR   EMBL; AACZ04070233; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_016780063.1; XM_016924574.1.
DR   PaxDb; 9598-ENSPTRP00000056845; -.
DR   Ensembl; ENSPTRT00000065279.3; ENSPTRP00000056845.3; ENSPTRG00000005610.6.
DR   KEGG; ptr:452355; -.
DR   VGNC; VGNC:13012; DNAH10.
DR   eggNOG; KOG3595; Eukaryota.
DR   GeneTree; ENSGT00940000154642; -.
DR   HOGENOM; CLU_000038_9_1_1; -.
DR   InParanoid; H2RC69; -.
DR   OMA; LHCHFGE; -.
DR   OrthoDB; 166463at2759; -.
DR   TreeFam; TF316836; -.
DR   Proteomes; UP000002277; Chromosome 12.
DR   Bgee; ENSPTRG00000005610; Expressed in testis and 14 other cell types or tissues.
DR   GO; GO:0097729; C:9+2 motile cilium; IBA:GO_Central.
DR   GO; GO:0005930; C:axoneme; IEA:UniProt.
DR   GO; GO:0030286; C:dynein complex; IBA:GO_Central.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR   GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR   GO; GO:0008569; F:minus-end-directed microtubule motor activity; IBA:GO_Central.
DR   GO; GO:0060294; P:cilium movement involved in cell motility; IBA:GO_Central.
DR   Gene3D; 1.10.287.2620; -; 1.
DR   Gene3D; 1.10.472.130; -; 1.
DR   Gene3D; 1.10.8.1220; -; 1.
DR   Gene3D; 1.10.8.710; -; 1.
DR   Gene3D; 1.20.1270.280; -; 1.
DR   Gene3D; 1.20.58.1120; -; 1.
DR   Gene3D; 1.20.920.20; -; 1.
DR   Gene3D; 1.20.920.30; -; 1.
DR   Gene3D; 3.10.490.20; -; 1.
DR   Gene3D; 6.10.140.1060; -; 1.
DR   Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR   Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR   Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR035699; AAA_6.
DR   InterPro; IPR035706; AAA_9.
DR   InterPro; IPR041658; AAA_lid_11.
DR   InterPro; IPR042219; AAA_lid_11_sf.
DR   InterPro; IPR026983; DHC_fam.
DR   InterPro; IPR041589; DNAH3_AAA_lid_1.
DR   InterPro; IPR042222; Dynein_2_N.
DR   InterPro; IPR043157; Dynein_AAA1S.
DR   InterPro; IPR041466; Dynein_AAA5_ext.
DR   InterPro; IPR041228; Dynein_C.
DR   InterPro; IPR043160; Dynein_C_barrel.
DR   InterPro; IPR024743; Dynein_HC_stalk.
DR   InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR   InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR   InterPro; IPR013602; Dynein_heavy_linker.
DR   InterPro; IPR013594; Dynein_heavy_tail.
DR   InterPro; IPR042228; Dynein_linker_3.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR10676:SF343; DYNEIN AXONEMAL HEAVY CHAIN 10; 1.
DR   PANTHER; PTHR10676; DYNEIN HEAVY CHAIN FAMILY PROTEIN; 1.
DR   Pfam; PF12774; AAA_6; 1.
DR   Pfam; PF12775; AAA_7; 1.
DR   Pfam; PF12780; AAA_8; 1.
DR   Pfam; PF12781; AAA_9; 1.
DR   Pfam; PF17857; AAA_lid_1; 1.
DR   Pfam; PF18198; AAA_lid_11; 1.
DR   Pfam; PF08385; DHC_N1; 2.
DR   Pfam; PF08393; DHC_N2; 1.
DR   Pfam; PF17852; Dynein_AAA_lid; 1.
DR   Pfam; PF18199; Dynein_C; 1.
DR   Pfam; PF03028; Dynein_heavy; 1.
DR   Pfam; PF12777; MT; 1.
DR   SMART; SM00382; AAA; 3.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW   Cilium {ECO:0000256|ARBA:ARBA00023069};
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW   Dynein {ECO:0000256|ARBA:ARBA00023017};
KW   Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW   Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002277}.
FT   DOMAIN          1887..2023
FT                   /note="AAA+ ATPase"
FT                   /evidence="ECO:0000259|SMART:SM00382"
FT   DOMAIN          2166..2302
FT                   /note="AAA+ ATPase"
FT                   /evidence="ECO:0000259|SMART:SM00382"
FT   DOMAIN          2508..2661
FT                   /note="AAA+ ATPase"
FT                   /evidence="ECO:0000259|SMART:SM00382"
FT   REGION          223..244
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          3108..3181
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          3322..3384
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        223..239
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   4532 AA;  521928 MW;  4E072DEE7EE49F35 CRC64;
     MDDLRVLWMR DRVYAAFGIT DPQLFEDLLN RDDGRGEDLI LHFLNQASEE EGPSALFIYR
     TMVPEEVEVE IDEIPVLSEE GEEEEETYSQ KVESVDKVRA KHVSLRTESL GQPLNREDEE
     TDKEISEKLP SKRTVKHIME KMHLHMLCTP LPEEFLDQNV VFFLRNTKEA ISEATDMKEA
     MEIMPETLEY GIINANVLHF LKNIICQVFL PALSFNQHRT STTVGVTSGE GSNSSEHESD
     LPPMPGEAVE YHSIQLIRDE FLMNVQKFAS NIQRTMQQLE GEIKLEMPTI SVEGEVSDLA
     ADPETVDILE QCVINWLNQI STAVEAQLKK TPQGKGPLAE IEFWRERNAT LSALHEQTKL
     PIVRKVLDVI KESNSMLVAN LQPVFTELFK FHTEASDNVR FLSTVERYFK NITHGSGFHV
     VLDTIPAMMS ALRMVWIISR HYNKDERMIP LMERIAWEIA ERVCRVVNLR TLFKENRASA
     QSKTLEARNT LRLWKKAYFD TRAKIEASGR EARWEFDRKR LFERTDYMAT ICQDLSDVLQ
     VLEEFYNIFG PELKAVTGDP KRIDDVLCRV DGLVTPMENL TFDPFSIKSS QFWKYVMDEF
     KIEVLIDIIN KIFVQNLENP PLYKNHPPVA GAIYWERSLF FRIKHTILRF QEVQEILDSD
     RGQEVKQKYL EVGRTMKEYE DRKYEQWMEV TEQVLPALMK KSLLTKSSIA TEEPSTLERG
     AVFAINFSPA LREIINETKY LEQLGFTVPE LARNVALQED KFLRYTDGIQ RMLDHYHMLM
     GTLNDAESVL LNDHSQELLR VFRSGYKRLN WNSLGIGDYI TGCKQAIGKF ESLVHQIHKN
     ADDISSRLTL IEAINLFKYP AAKSEEELPG VKEFFEHIER ERASDVDHMV RWYLAIGPLL
     TKVEGLVVHT NTGKAPKLAS YYKHWEKKIY EVLTKLILKN LQSFNSLILG NVPLFHTETI
     LTAPEIILHP NTNEIDKMCF HCVRNCVEIT KHFVRWMNGS CIECPPQKGE EEEVVIINFY
     NDISLNPQII EQAVMIPQNV HRILINLMKY LQKWKRYRPL WKLDKAIVME KFAAKKPPCV
     AYDEKLQFYS KIAYEVMRHP LIKDEHCIRL QLGHLANTVQ ENAKSWVISL GKLLNESAKE
     ELYNLHEEME HLAKNLRKIP NTLEDLKFVL ATIAEIRSKS LVMELRYRDV QERYRTMAMY
     NLFPPDAEKE LVDKIESMWS NLFNDSVNVE HALGDIKRTF TELTRGEIMN YRVQIEEFAK
     RFYNEGPGSV GDDLDKGVEL LGVYERELAR HEKSRQELAN AEKLFDLPIT MYPELLKVQK
     EMSGLRMIYE LYEGLKVAKE EWSQTLWINL NVQILQEGIE GFLRALRKLP RPVRGLSVTY
     YLEAKMKAFK DSIPLLLDLK NEALRDRHWK ELMEKTSVFF EMTETFTLEN MFAMELHKHT
     DVLNEIVTAA IKEVAIEKAV KEILDTWENM KFSVVKYCKG TQERGYILGS VDEIIQSLDD
     NTFNLQSISG SRFVGPFLQT VHKWEKTLSL IGEVIEIWML VQRKWMYLES IFIGGDIRSQ
     LPEEAKKFDN IDKVFKRIMG ETLKDPVIKR CCEAPNRLSD LQNVSEGLEK CQKSLNDYLD
     SKRNAFPRFF FISDDELLSI LGSSDPLCVQ EHMIKMYDNI ASLRFNDGDS GEKLVSAMIS
     AEGEVMEFRK IVRAEGRVED WMTAVLNEMR RTNRLITKEA IFRYCEDRSR VDWMLLYQGM
     VVLAASQVWW TWEVEDIFHK AQKGEKQAMK SYGRKMHRQI DELVMRITMP LSKNDRKKYN
     TVLIIDVHAR DIVDSFIRGS ILEAREFEWE SQLRFYWDRE PDELNIRQCT GTFGYGYEYM
     GLNGRLVITP LTDRIYLTLT QALSMYLGGA PAGPAGTGKT ETTKDLAKAL GLLCVVTNCG
     EGMDYKAVGK IFSGLAQCGA WGCFDEFNRI DASVLSVISS QIQTIRNALI HQLTTFQFEG
     QEISLDSRMG IFITMNPGYA GRTELPESVK ALFRPVVVIV PDLQQICEIM LFSEGFLEAK
     TLAKKMTVLY KLAREQLSKQ YHYDFGLRAL KSVLVMAGEL KRGSSDLRED VVLMRALRDM
     NLPKFVFEDV PLFLGLISDL FPGLDCPRVR YPDFNDAVEQ VLEESGYAVL PIQVDKVVQM
     FETMLTRHTT MVVGPTRGGK SVVINTLCQA QTKLGLMTKL YILNPKAVSV IELYGILDPT
     TRDWTDGVLS NIFREINKPT DKKERKYILF DGDVDALWVE NMNSVMDDNR LLTLANGERI
     RLQAHCALLF EVGDLQYASP ATVSRCGMVY VDPKNLKYRP YWKKWVNQIP NKVEQYNLNS
     LFEKYVPYLM DVIVEGIVDG RQAEKLKTIV PQTDLNMVTQ LAKMLDALLE GEIEDLDLLE
     CYFLEALYCS LGASLLEDGR MKFDEYIKRL ASLSTVDTEG VWANPGELPG QLPTLYDFHF
     DNKRNQWVPW SKLVPEYIHA PERKFINILV HTVDTTRTTW ILEQMVKIKQ PVIFVGESGT
     SKTATTQNFL KNLSEETNIV LMVNFSSRTT SMDIQRNLEA NVEKRTKDTY GPPMGKRLLV
     FMDDMNMPRV DEYGTQQPIA LLRLLLEKGY LYDRGKELNC KSIRDLGFIA AMGKAGGGRN
     EVDPRFISLF SVFNVPFPSE ESLHLIYSSI LKGHTSTFHE SIVAVSGKLT FCTLALYKNI
     VQDLPPTPSK FHYIFNLRDL SRVFNGLVLT NPERFQTVAQ MVRVWRNECL RVFHDRLISE
     TDKQLVQQHI GSLVVEHFKD DVEVVMRDPI LFGDFQMALH EGEPRIYEDI QDYEAAKALF
     QEILEEYNES NTKMNLVLFD DALEHLTRVH RIIRMDRGHA LLVGVGGSGK QSLSRLAAFT
     ASCEVFEILL SRGYSENNFR EDLKSLYLKL GIENKAMIFL FTDAHVAEEG FLELINNMLT
     SGIVPALFSE EEKESILSQI GQEALKQGMG PAKESVWQYF VNKSANNLHI VLGMSPVGDT
     LRTWCRNFPG MVNNTGIDWF MPWPPQALHA VAKSFLGYNP MIPAENIENV VKHVVLVHQS
     VGHYSKQFLQ KLRRSNYVTP KNYLDFINTY SKLLDEKTQY NIAQCKRLDG GLDKLKEATI
     QLDELNQKLA EQKIVLAEKS AACEALLEEI AINTAVAEEK KKLAEEKAME IEEQNKVIAM
     EKDEAETTLA EVMPILEAAK LELQKLDKSD VTEIRSFAKP PKQVQTVCEC ILIMKGYKEL
     NWKTAKGVMS DPNFLRSLME IDFDSITQSQ VKNIKGLLKT LNTTTEEMEA VSKAGLGMLK
     FVEAVMGYCD VFREIKPKRE KVARLERNFY LTKRELERIQ NELAAIQKEL ETLGAKYEAA
     ILEKQKLQEE AEIMERRLIA ADKLISGLGS ENIRWLNDLD ELMHQRVKLL GDCLLCAAFL
     SYEGAFTWEF RDEMVNRIWQ NDILEREIPL SQPFRLESLL TDDVEISRWG SQGLPPDELS
     VQNGILTTRA SRFPLCIDPQ QQALNWIKRK EEKNNLRVAS FNDPDFLKQL EMSIKYGTPF
     LFRDVDEYID PVIDNVLEKN IKVSQGRQFI ILGDKEVDYD SNFRLYLNTK LANPRYSPSV
     FGKAMVINYT VTLKGLEDQL LSVLVAYERR ELEEQREHLI QETSENKNLL KDLEDSLLRE
     LATSTGNMLD NVDLVHTLEE TKSKATEVSE KLKLAEKTAL DIDRLRDGYR PAARRGAILF
     FVLSEMALVN SMYQYSLIAF LEVFRLSLKK SLPDSILMKR LRNIMDTLTF NIYNYGCTGL
     FERHKLLFSF NMTIKIEQAE GRVPQEELDF FLKGNISLEK SKRKKPCAWL SDQGWEDIIL
     LSEMFSDNFG QLPDDVENNQ TVWQEWYDLD SLEQFPFPLG YDNNITPFQK LLILRCFRVD
     RVYRAVTDYV TVTMGEKYVQ PPMISFEAVF EQSTPHSPVV FILSPGSDPA TDLMKLAERS
     GFGGNRLKFL AMGQGQEKVA LQLLETAVAR GQWLMLQNCH LLVKWLKDLE KSLERITKPH
     PDFRLWLTTD PTKGFPIGIL QKSLKVVTEP PNGLKLNMRA TYFKISHEML DQCPHPAFKP
     LVYVLAFFHA VVQERRKFGK IGWNVYYDFN ESDFQVCMEI LNTYLTKAFQ QRDPRIPWGS
     LKYLIGEVMY GGRAIDSFDR RILTIYMDEY LGDFIFDTFQ PFHFFRNKEV DYKIPVGDEK
     EKFVEAIEAL PLANTPEVFG LHPNAEIGYY TQAARDMWAH LLELQPQTGE SSSGISRDDY
     IGQVAKEIEN KMPKVFDLDQ VRKRLGTGLS PTSVVLLQEL ERFNKLVVRM TKSLAELQRA
     LAGEVGMSNE LDDVARSLFI GHIPNIWRRL APDTLKSLGN WMVYFLRRFS QYMLWVTESE
     PSVMWLSGLH IPESYLTALV QATCRKNGWP LDRSTLFTQV TKFQDADEVN ERAGQGCFVS
     GLYLEGADWD IEKGCLTKSK PKVLVVDLPI LKIIPIEAHR LKLQNTFRTP VYTTSMRRNA
     MGVGLVFEAD LFTTRHISHW VLQGVCLTLN SD
//

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